公开(公告)号：AU1326702A

公开(公告)日：2002-04-29

申请号：AU1326702

申请日：2001-10-16

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAM LY TAM ,  CLARK RICHARD F ,  ZHANG SOUMING ,  DJURIC STEVAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

公开(公告)号：AT368647T

公开(公告)日：2007-08-15

申请号：AT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN ,  WIEDEMAN PAUL ,  YONG HONG ,  MICHMERHUIZEN MELISSA ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING ,  STEWART KENT ,  SZCZEPANKIEWICZ BRUCE

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：BR0109946A

公开(公告)日：2005-08-02

申请号：BR0109946

申请日：2001-10-16

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  CLARK RICHARD F ,  ZHANG SOUMING ,  DJURIC STEVAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

公开(公告)号：CA2476223A1

公开(公告)日：2003-08-21

申请号：CA2476223

申请日：2003-02-11

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  CLARK RICHARD ,  WANG SANYI ,  DJURIC STEVAN

IPC: A61K31/7056 ,  A61P31/04 ,  A61P43/00 ,  C07H17/08 ,  A61K31/7048

Abstract: Antibacterial compounds having formula (I), and salts, prodrugs, and salts o f prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：PE20020522A1

公开(公告)日：2002-06-25

申请号：PE2001001021

申请日：2001-10-15

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

Abstract: SE REFIERE A DERIVADOS DE ERITROMICINA (CETOLIDOS 6-O-SUSTITUIDOS) DE FORMULA I DONDE A1 ES ARILO, HETEROARILO; Y1 ES ISOXAZOL, OXAZOL, ISOTIAZOL, DIHIDROISOXAZOL, DIHIDROOXAZOL; D1 ES HC-CH; C C; R1 ES H, Rp; Rp ES UN GRUPO PROTECTOR DE OH. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS SIN PRODUCIR EL EFECTO COLATERAL DE INTOLERANCIA INTESTINAL COMO NAUSEAS, VOMITOS

公开(公告)号：CA2420012A1

公开(公告)日：2002-04-25

申请号：CA2420012

申请日：2001-10-16

Applicant: ABBOTT LAB

Inventor： PHAM LY TAM ,  CLARK RICHARD F ,  MA ZHENKUN ,  DJURIC STEVAN ,  ZHANG SOUMING

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

Abstract: Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.