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    ERYTHROMYCINDERIVATE
    11.
    发明专利
    ERYTHROMYCINDERIVATE 未知

    公开(公告)号：DE69418715D1

    公开(公告)日：1999-07-01

    申请号：DE69418715

    申请日：1994-07-06

    Applicant: ABBOTT LAB

    Inventor： EDWARDS CARLA ,  LARTEY PAUL A

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

    Amino-lipopeptide antifungal agents
    13.
    发明专利
    Amino-lipopeptide antifungal agents 未知

    公开(公告)号：AU4059197A

    公开(公告)日：1998-03-06

    申请号：AU4059197

    申请日：1997-08-11

    Applicant: ABBOTT LAB

    Inventor： LARTEY PAUL A ,  LI LEPING ,  KLEIN LARRY L ,  LEONE CHRISTINE L ,  THOMAS SHEELA A ,  YEUNG MING C ,  DEGOEY DAVID A ,  .RAMPOVNIK DAVID J

    IPC: A61K38/00 ,  C07K7/56 ,  A61K38/12

    Abstract: Disclosed are novel antifungal agents having the formula: I or a pharmaceutically acceptable acid, ester or prodrug thereof, wherein preferred compounds include those compounds wherein R1 is selected from the group consisting of -NH2; R2 is selected from the group consisting of hydrogen, fluoro, and hydroxyl; R3 is selected from the group consisting of -CH2(p-C6H4)3O(CH2)3CH3, -CH2(p-C6H4)O(CH2)6CH3, -COO(p-C6H4)O(CH2)6CH3, -CO(Piperazinyl)(p-C6H4)2OCH3, -CO(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)4CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)OCH3, and -CO(p-C6H4)(Piperazinyl)O(CH2)6CH3; and R4 is selected from the group consisting of -CH(OH)CH3, -CH2OH, -CH2CH3, -CH2CH2CH2NH2, -CH2(CH2)NH2, -CH2NH2, -CH2(CH2)2(NH)C=(NH)-NH2, -CH3, -CH2(Ph)OH, hydrogen, -CH2CH2COOH, and -CH2COOH. Also disclosed are pharmaceutical compositions containing such compounds and the use of the same in the treatment of fungal infections.

    ERYTHROMYCIN DERIVATIVES
    16.
    发明专利
    ERYTHROMYCIN DERIVATIVES 未知

    公开(公告)号：CA2165078A1

    公开(公告)日：1995-01-19

    申请号：CA2165078

    申请日：1994-07-06

    Applicant: ABBOTT LAB

    Inventor： EDWARDS CARLA ,  LARTEY PAUL A

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    Abstract: Antibacterial compounds having formula (II) and pharmaceutically acceptable salts thereof, wherein Y is selected form (a), (b), and (c) and X is selected from the group consisting of -C(O)-, -C(S)-, CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

    17.
    发明专利
    未知

    公开(公告)号：PT100442A

    公开(公告)日：1993-08-31

    申请号：PT10044292

    申请日：1992-04-30

    Applicant: ABBOTT LAB

    Inventor： LARTEY PAUL A ,  DENINNO SHARI ,  FEGHIH RAMIN

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    Abstract: Antibacterial compounds are disclosed having the formula and pharmaceutically acceptable salts thereof, wherein R1 is -NR4R6, where R4 and R6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R4 and R6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R2 is selected from the group consisting of hydrogen, -OH and, when R3 is methylene, oxygen so as to form an epoxide; and R3 is selected from the group consisting of -CH2OH, -NR4R6, -(CH2)nNR4R6 and, when R2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R4 and R6 are as previously defined, with the proviso that when R2 is -OH, R3 may not be -NR4R6; or R2 and R3 together are=CH2. Also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

    ERYTHROMYCIN DERIVATIVES
    18.
    发明专利
    ERYTHROMYCIN DERIVATIVES 未知

    公开(公告)号：CA2107793A1

    公开(公告)日：1992-11-04

    申请号：CA2107793

    申请日：1992-04-09

    Applicant: ABBOTT LAB

    Inventor： LARTEY PAUL A ,  DININNO SHARI ,  FEGHIH RAMIN

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    Abstract: 2107793 9219247 PCTABS00017 Antibacterial compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is -NR4R6, where R4 and R6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R4 and R6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R2 is selected from the group consisting of hydrogen, -OH and, when R3 is methylene, oxygen so as to form an epoxide; and R3 is selected from the group consisting of -CH2OH, -NR4R6, -(CH2)nNR4R6 and, when R2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R4 and R6 are as previously defined, with the proviso that when R2 is -OH, R3 may not be -NR4R6; or R2 and R3 together are =CH2; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same methods for their use.

    20.
    发明专利
    未知

    公开(公告)号：DK0707482T3

    公开(公告)日：1999-12-06

    申请号：DK94923344

    申请日：1994-07-06

    Applicant: ABBOTT LAB

    Inventor： EDWARDS CARLA ,  LARTEY PAUL A

    IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

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