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公开(公告)号：ZA200506760B
公开(公告)日：2006-06-28
申请号：ZA200506760
申请日：2005-08-23
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , LI GAOQUAN , SHAM HING , SULLIVAN GERARD M , XIA PING , HEXAMER LAURA , LIN NAN-HORNG , SOWIN TOM , WANG LE
IPC: A61K20060101 , A61P20060101 , C07D20060101
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公开(公告)号：PL378116A1
公开(公告)日：2006-03-06
申请号：PL37811604
申请日：2004-02-26
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , HEXAMER LAURA , LI GAOQUAN , LIN NAN-HORNG , SHAM HING , SOWIN TOM , SULLIVAN GERARD M , WANG LE , XIA PING XIA
IPC: C07D243/38 , A61K31/551 , A61P35/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10
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公开(公告)号：DK1181269T3
公开(公告)日：2004-07-05
申请号：DK00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W , STEINER BETH A
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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公开(公告)号：BR0007589A
公开(公告)日：2002-10-15
申请号：BR0007589
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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15.发明专利
公开(公告)号：CA2641766A1
公开(公告)日：2007-08-23
申请号：CA2641766
申请日：2007-02-15
Applicant: ABBOTT LAB
Inventor： SHAM HING , GU YU GUI , XU XIANGDONG , WEITZBERG MOSHE
IPC: C07D277/34 , A61K31/426 , A61K31/427 , C07D417/04
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Patent Agency Ranking16.发明专利
公开(公告)号：CA2641734A1
公开(公告)日：2007-08-23
申请号：CA2641734
申请日：2007-02-15
Applicant: ABBOTT LAB
Inventor： CLARK RICHARD F , ZHANG TIANYUAN , HANSEN TODD M , LI QUN , WEITZBERG MOSHE , GU YU GUI , BEUTEL BRUCE A , XU XIANGDONG , CAMP HEIDI S , SHAM HING , WANG XIAOJUN
IPC: C07D277/34 , A61K31/427 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
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公开(公告)号：AT368647T
公开(公告)日：2007-08-15
申请号：AT03774478
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN , WIEDEMAN PAUL , YONG HONG , MICHMERHUIZEN MELISSA , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING , STEWART KENT , SZCZEPANKIEWICZ BRUCE
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
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公开(公告)号：BRPI0407841A
公开(公告)日：2006-11-14
申请号：BRPI0407841
申请日：2004-02-26
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , HEXAMER LAURA , LI GAOQUAN , LIN NANHORNG , SHAM HING , SOWIN TOM , SULLIVAN GERARD M , WANG LE , XIA PING XIA
IPC: A61P35/00 , C07D243/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10
Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：ES2215668T3
公开(公告)日：2004-10-16
申请号：ES00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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公开(公告)号：CA2517885A1
公开(公告)日：2004-09-23
申请号：CA2517885
申请日：2004-03-04
Applicant: ABBOTT LAB
Inventor： SHAM HING , LIN NAN-HORNG , CLAIBORNE AKIYO K , LI GAOQUAN , TAO ZHI-FU , TONG YUNSONG , SOWIN TOM
IPC: A61P35/00 , C07D231/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D521/00 , A61K31/416 , C07D403/14 , C07D417/12
Abstract: Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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