公开(公告)号：EP1891072A2

公开(公告)日：2008-02-27

申请号：EP06759877.1

申请日：2006-05-16

Applicant: ABBOTT LABORATORIES

Inventor： GRACIAS, Vijaya, J. ,  ABAD-ZAPATERO, Celerino ,  DJURIC, Stevan, W. ,  JI, Zhiqin ,  MICHAELIDES, Michael, R. ,  STEWART, Kent, D. ,  ZANZE, Irini

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP2299821A1

公开(公告)日：2011-03-30

申请号：EP09763424.0

申请日：2009-06-09

Applicant: Abbott Laboratories

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/42

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：EP1560811B9

公开(公告)日：2008-03-05

申请号：EP03774478.6

申请日：2003-09-15

Applicant: ABBOTT LABORATORIES

Inventor： MADAR, David ,  PEI, Zhonghua ,  PIREH, Daisy ,  DJURIC, Stevan, W. ,  WIEDEMAN, Paul, E. ,  YONG, Hong ,  MICHMERHUIZEN, Melissa, J. ,  KOPECKA, Hana ,  LI, Xiaofeng ,  LONGENECKER, Kenton ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  SZCZEPANKIEWICZ, Bruce, G.

IPC: C07D207/00

CPC classification number: C07D207/27 ,  C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

公开(公告)号：EP1000018A2

公开(公告)日：2000-05-17

申请号：EP98937082.0

申请日：1998-07-24

Applicant: Abbott Laboratories

Inventor： GEYER, Andrew, G. ,  MCCLELLAN, William, J. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WEITZBERG, Moshe ,  WENDT, Michael, D.

IPC: C07C249/00

CPC classification number: C07D249/08 ,  C07C257/18 ,  C07C259/18 ,  C07C271/22 ,  C07C271/30 ,  C07C271/66 ,  C07C275/40 ,  C07C311/13 ,  C07C311/16 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/08 ,  C07D209/08 ,  C07D213/58 ,  C07D213/74 ,  C07D215/38 ,  C07D217/02 ,  C07D231/12 ,  C07D231/40 ,  C07D231/56 ,  C07D233/56 ,  C07D237/20 ,  C07D239/34 ,  C07D239/42 ,  C07D239/545 ,  C07D241/18 ,  C07D241/20 ,  C07D261/14 ,  C07D263/32 ,  C07D277/34 ,  C07D277/42 ,  C07D295/088 ,  C07D303/46 ,  C07D307/16 ,  C07D307/18 ,  C07D307/54 ,  C07D307/64 ,  C07D317/68 ,  C07D333/24 ,  C07D405/12

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.

Abstract translation: 具有式（I）的化合物是尿激酶的抑制剂，可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物和抑制哺乳动物尿激酶的方法。

公开(公告)号：EP1560811B1

公开(公告)日：2007-08-01

申请号：EP03774478.6

申请日：2003-09-15

Applicant: ABBOTT LABORATORIES

Inventor： MADAR, David ,  PEI, Zhonghua ,  PIREH, Daisy ,  DJURIC, Stevan, W. ,  WIEDEMAN, Paul, E. ,  YONG, Hong ,  MICHMERHUIZEN, Melissa, J. ,  KOPECKA, Hana ,  LI, Xiaofeng ,  LONGENECKER, Kenton ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  SZCZEPANKIEWICZ, Bruce, G.

IPC: C07D207/00

CPC classification number: C07D207/27 ,  C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

公开(公告)号：EP1560811A2

公开(公告)日：2005-08-10

申请号：EP03774478.6

申请日：2003-09-15

Applicant: Abbott Laboratories

Inventor： MADAR, David ,  PEI, Zhonghua ,  PIREH, Daisy ,  DJURIC, Stevan, W. ,  WIEDEMAN, Paul, E. ,  YONG, Hong ,  FEENSTRA, Melissa, J. ,  KOPECKA, Hana ,  LI, Xiaofeng ,  LONGENECKER, Kenton ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  SZCZEPANKIEWICZ, Bruce, G.

IPC: C07D207/00

CPC classification number: C07D207/27 ,  C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

公开(公告)号：EP1379646A2

公开(公告)日：2004-01-14

申请号：EP01988771.0

申请日：2001-10-26

Applicant: ABBOTT LABORATORIES

Inventor： STEWART, Kent, D. ,  STEFFY, Kevin, R. ,  KEMPF, Dale, J. ,  HARRIS, Kevin, S. ,  HUTH, Jeffrey, R. ,  STOLL, Vincent, S. ,  HARLAN, John, E. ,  NG, Iok, C. ,  BETZ, Stephen, F.

IPC: C12N15/11 ,  C07K14/16 ,  G01N33/569

CPC classification number: C40B30/04 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/16122 ,  G01N33/56988 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2500/04

Abstract: The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV-1) gp41 protein and to methods of use thereof. For example, the proteins may be utilized in the screening of anti-HIV compounds.

公开(公告)号：EP2203431A1

公开(公告)日：2010-07-07

申请号：EP08832330.8

申请日：2008-09-17

Applicant: Abbott Laboratories

Inventor： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：EP1919854A2

公开(公告)日：2008-05-14

申请号：EP06790057.1

申请日：2006-08-25

Applicant: ABBOTT LABORATORIES

Inventor： PEI, Zhonghua ,  VON GELDERN, Thomas ,  MADAR, David, J. ,  LI, Xiaofeng ,  BASHA, Fatima ,  YONG, Hong ,  LONGENECKER, Kenton, L. ,  BACKES, Bradley, J. ,  JUDD, Andrew, S. ,  MULHERN, Mathew, M. ,  STEWART, Kent, D.

IPC: C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04 ,  A61K31/137

CPC classification number: C07C211/48 ,  C07C211/40 ,  C07C217/52 ,  C07C217/54 ,  C07C217/74 ,  C07C217/84 ,  C07C217/86 ,  C07C225/22 ,  C07C229/42 ,  C07C229/48 ,  C07C229/60 ,  C07C233/43 ,  C07C233/78 ,  C07C235/46 ,  C07C237/24 ,  C07C237/30 ,  C07C237/42 ,  C07C255/54 ,  C07C255/58 ,  C07C311/22 ,  C07C311/36 ,  C07C317/22 ,  C07C317/36 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/16 ,  C07D209/08 ,  C07D209/48 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/64 ,  C07D213/68 ,  C07D213/74 ,  C07D213/82 ,  C07D217/04 ,  C07D263/56 ,  C07D263/60 ,  C07D277/04 ,  C07D277/64 ,  C07D295/135 ,  C07D295/185 ,  C07D295/205 ,  C07D317/66 ,  C07D319/18 ,  C07D333/34 ,  C07D333/38 ,  C07D409/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病， 和其他疾病。

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC: C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC classification number: C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。