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    11.
    发明专利
    未知

    公开(公告)号：CH615430A5

    公开(公告)日：1980-01-31

    申请号：CH211975

    申请日：1975-02-20

    Applicant: BASF AG

    Inventor： AMANN AUGUST DR ,  KOENIG HORST DR ,  THIEME PETER DR ,  GIERTZ HUBERT PROF DR ,  KRETZSCHMAR ROLF DR

    IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125

    Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

    8-Acyloxyquinoline derivs prepn - with antibacterial and antifungal activity
    20.
    发明专利
    8-Acyloxyquinoline derivs prepn - with antibacterial and antifungal activity 未知

    公开(公告)号：DE2237903A1

    公开(公告)日：1974-03-28

    申请号：DE2237903

    申请日：1972-08-02

    Applicant: BASF AG

    Inventor： BECKE FRIEDRICH DR ,  AMANN AUGUST DR ,  BITTERMANN HERBERT DR

    IPC: C07D215/32 ,  C07D33/44

    Abstract: Title derivs. are of formula (I): (where R' is H, Cl, Br or I; R2 is H, Cl, Br, I or NO2; and R3 is an alpha,beta-olefinically unsatd. aliphatic residue, or a bridge member linked with an 8-hydroxyquinoline ester residue of (I)) and acceptable salts, and can be prepd. by esterifying corresp. 8-hydroxyquinolines with a reactive deriv. of an acid R3-COOH, have bacteriostatic or bactericidal and fungistatic or fungicidal activity and can be used in conventional formulations such as ointments, tinctures, solns., sprays and dusts.

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