公开(公告)号：DK149590C

公开(公告)日：1987-02-09

申请号：DK532679

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  KUNZE JOHANNES ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：FI71132B

公开(公告)日：1986-08-14

申请号：FI801228

申请日：1980-04-17

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D401/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：NO153495C

公开(公告)日：1986-05-14

申请号：NO801387

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFAGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：FI70013B

公开(公告)日：1986-01-31

申请号：FI802960

申请日：1980-09-19

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  PHILIPSBORN GERDA VON ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：HU187327B

公开(公告)日：1985-12-28

申请号：HU73881

申请日：1981-03-23

Applicant: BASF AG

Inventor： MAY HANS-JOACHIM ,  LENKE DIETER ,  GRIES JOSEF ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG

IPC: C07D409/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D407/06

Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula where R1 and R2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano, R3 has the meanings given for R1 and R2 or is hydrogen and Ar is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds. The compounds have, inter alia, a blood pressure-reducing action.

公开(公告)号：AU548410B2

公开(公告)日：1985-12-12

申请号：AU8220682

申请日：1982-03-31

Applicant: BASF AG

Inventor： STEINER GERD ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59 ,  C07D413/06

公开(公告)号：CA1194024A

公开(公告)日：1985-09-24

申请号：CA423169

申请日：1983-03-09

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26

Abstract: 6-aryl-4,5-dihydro-3(2H)-pyridazinones of the formula (I), where R is hydrogen, R1 is hydrogen or C1-C3-alkyl, or R and R1 together are methylene, R2 and R3 are identical or different and are each hydrogen or C1-C6-alkyl, and A is hydroxyl, C1-C6-alkoxy, C2-C7-acyloxy, a C2-C7-carbamic acid ester group, C1-C6-alkylsul-fonyloxy, C1-C6-alkylmercapto, carboxyl, C2-C7-alkoxy-carbonyl or nitrile, and their preparation are described. The substances are suitable for the treatment of high blood pressure or thrombo-embolic disorders.

公开(公告)号：ZA849380B

公开(公告)日：1985-08-28

申请号：ZA849380

申请日：1984-12-03

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D ,  A61K

公开(公告)号：NO844778A

公开(公告)日：1985-06-03

申请号：NO844778

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D

CPC classification number: C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：CS236500B2

公开(公告)日：1985-05-15

申请号：CS712783

申请日：1983-09-29

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/135 ,  A61K31/395 ,  C07D295/08 ,  C07D295/10 ,  C07C97/10 ,  C07C93/06 ,  C07D341/12