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公开(公告)号：AT188485T
公开(公告)日：2000-01-15
申请号：AT95917963
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：DE19735410A1
公开(公告)日：1999-02-18
申请号：DE19735410
申请日：1997-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHAEFER BERND , THYES MARCO , HOEGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-(3-(4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl)propylmercapto)pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new.
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公开(公告)号：DE59504450D1
公开(公告)日：1999-01-14
申请号：DE59504450
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号：AU688037B2
公开(公告)日：1998-03-05
申请号：AU2408395
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , POTZOLLI BERND DE , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：ZA9503584B
公开(公告)日：1996-11-04
申请号：ZA9503584
申请日：1995-05-04
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , POTZOLLI BERND DE , RITTER KURT , THYES MARCO , ZIERKE THOMAS
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Patent Agency Ranking
公开(公告)号：CA2189690A1
公开(公告)日：1995-11-16
申请号：CA2189690
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR1, wherein Z and R1 have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.
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公开(公告)号：DE3768470D1
公开(公告)日：1991-04-11
申请号：DE3768470
申请日：1987-12-17
Applicant: BASF AG
Inventor： THYES MARCO , STEINER GERD
IPC: C07C63/331 , C07C51/00 , C07C51/353 , C07C63/66 , C07C63/74 , C07C65/28 , C07C67/00 , C07C201/00 , C07C205/06 , C07C205/56 , C07C253/00 , C07C255/50 , C07C255/57
Abstract: (Z)-2-(2-arylethenyl)arylcarboxylic acids of the general formula I (I) where A is a group for completing an aromatic ring system and Ar is an aromatic radical, are prepared by reacting a 2-formylarylcarboxylic acid of the general formula II (II) with an (arylmethyl)phosphonium salt of the general formula III (III) where R1, R2 and R3 are each organic radicals and X is halogen, in the presence of a base at from (-20 DEG ) to +30 DEG C. by carrying out the reaction in the presence of a C1-C5-alkanol and/or a C2-C4-alkanediol.
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公开(公告)号：AT61331T
公开(公告)日：1991-03-15
申请号：AT87118718
申请日：1987-12-17
Applicant: BASF AG
Inventor： THYES MARCO , STEINER GERD
IPC: C07C63/331 , C07C51/00 , C07C51/353 , C07C63/66 , C07C63/74 , C07C65/28 , C07C67/00 , C07C201/00 , C07C205/06 , C07C205/56 , C07C253/00 , C07C255/50 , C07C255/57
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公开(公告)号：CA1269376A
公开(公告)日：1990-05-22
申请号：CA513129
申请日：1986-07-04
Applicant: BASF AG
Inventor： STEINER GERD , THYES MARCO
IPC: C07D333/00 , C07D409/14 , C07D495/14 , C07D403/14
Abstract: A novel process for the preparation of 4,5-dihy-drodithieno¢3,4-b:3',4'-e!azepine-5,9-dione is described, which process comprises the cyclization reaction of an ester of the formula IV: IV where n is 0, 1 or 2 and R1 and R2 are identical or different and are each C1-C4-alkyl, or, where n is 0, R1 and R2, together with the carbon atoms to which they are bonded, form a benzene nucleus.
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公开(公告)号：FI74955C
公开(公告)日：1988-04-11
申请号：FI823762
申请日：1982-11-03
Applicant: BASF AG
Inventor： KROPP RUDOLF , THYES MARCO , SCHLECKER RAINER , FRANKE ALBRECHT , REICHENEDER FRANZ , AMANN AUGUST , TESCHENDORF HANS-JUERGEN , KRETZSCHMAR ROLF , TRAUT MARTIN , GRIES JOSEF
IPC: A61K31/50 , A61P9/02 , A61P25/00 , A61P25/24 , A61P25/26 , C07D237/20 , C07D237/22
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