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    11.
    发明专利
    未知

    公开(公告)号：DK0441207T3

    公开(公告)日：1994-05-02

    申请号：DK91101013

    申请日：1991-01-26

    Applicant: BASF AG

    Inventor： AMMERMANN EBERHARD DR ,  LORENZ GISELA DR ,  LAUER MANFRED DR ,  GOETZ NORBERT DR ,  ZIPPERER BERNHARD DR ,  ZIERKE THOMAS DR

    IPC: A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  C07D213/30 ,  C07D213/50 ,  C07D401/06 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06

    Abstract: Heteroarylalkenes of the general formula I … …… … (Ar = heteroaryl, … A = C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, (C3-C8)-cycloalkyl-(C1-C3)-alkyl, mono-, di- or tricyclic substituted or unsubstituted aryl or aralkyl; … Z = … … where …… R = hydrogen, C2-C4-acyl, optionally substituted benzoyl, C1-C4-alkylsulphonyl, phenylsulphonyl which is unsubstituted or substituted by C1-C4-alkyl, or the radical R , … R is C1-C4-alkyl, substituted or unsubstituted phenyl or benzyl and … Hal is fluorine, chlorine, bromine or iodine; …… B is substituted or unsubstituted mono- or dicyclic aryl, aralkyl or heteroaryl) … and their N-oxides and acid addition salts; furthermore the preparation of these substances, intermediates therefor and their preparation, heteroarylalkene-containing fungicidal agents, and a suitable method for controlling fungal pests.

    13.
    发明专利
    未知

    公开(公告)号：DE3901327A1

    公开(公告)日：1990-07-19

    申请号：DE3901327

    申请日：1989-01-18

    Applicant: BASF AG

    Inventor： ZIERKE THOMAS DR ,  SAUTER HUBERT DR ,  SCHULZ GUENTER DR ,  WILL WOLFGANG DR

    IPC: C07C49/83 ,  C07D303/14 ,  C07F7/18

    Abstract: Process for the preparation of 1-hydroxymethyloxiranes Z-substituted in position 2, of the general formulae I and ent-I, in which the substituents A and B independently of one another denote C1-C4-alkyl, phenyl, naphthyl, diphenyl or phenyl substituted by one to three radicals from the group comprising halogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, nitro and phenoxy, in which ketones of the general formula II in which A and B have the abovementioned meanings and X stands for a group which can be eliminated under the reaction conditions, are reacted with trimethylsulphonium methylsulphate and a suitable base or with dimethyloxosulphonium methylide, and novel ketones of the general formula II' in which the substituents A' denotes phenyl or 4-fluorophenyl, B' denotes 2-fluorophenyl, 2-chlorophenyl, 2-bromophenyl or 2-trifluoromethylphenyl and X' denotes hydroxyl or a leaving group, with the proviso that B' does not stand for 2-chlorophenyl when A' denotes phenyl.

    DOLASTATIN 15 DERIVATIVES
    14.
    发明专利
    DOLASTATIN 15 DERIVATIVES 未知

    公开(公告)号：HU0004234A2

    公开(公告)日：2001-05-28

    申请号：HU0004234

    申请日：1998-07-07

    Applicant: BASF AG

    Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS DR ,  ZIERKE THOMAS DR

    IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

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