公开(公告)号：DE2142563A1

公开(公告)日：1973-05-03

申请号：DE2142563

申请日：1971-08-25

Applicant: HOECHST AG

Inventor： RUSCHIG HEINRICH PROF DR ,  SEIDL GUENTHER ,  SCHMITT KARL DR ,  ALPERMANN HANS-GEORG DR ,  SELIGER HUBERT

IPC: C07D209/44 ,  C07D27/48

公开(公告)号：ZA892089B

公开(公告)日：1989-10-25

申请号：ZA892089

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  KLESEL NORBERT ,  NORBERT KLESEL ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  SELIGER HUBERT ,  HUBERT SELIGER ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D ,  A61K

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：DK138789A

公开(公告)日：1989-09-23

申请号：DK138789

申请日：1989-03-21

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：AU2042288A

公开(公告)日：1989-04-20

申请号：AU2042288

申请日：1988-08-04

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  SELIGER HUBERT ,  DOST GUNTER ,  CHATTERJEE SUGATA ,  DESIKAN KALYANAPURAM RAJAGOPAL ,  RUPP RICHARD HELMUT ,  GANGULI BIMAL NARESH ,  FRANCO CHRISTOPHER MILTON MATH

IPC: A23K20/195 ,  A61K38/00 ,  A61P3/00 ,  C07K1/02 ,  C07K7/06 ,  C12P21/04 ,  A23K1/17

Abstract: Streptogramin B metal complexes, especially the Cu, Zn and Mn complexes of etamycin, are valuable production promoters in livestock nutrition. They are obtained by reacting neoviridogriseins with metal salts in solution and subsequent neutralisation with bases.

公开(公告)号：FI891304A0

公开(公告)日：1989-03-20

申请号：FI891304

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：CA1106358A

公开(公告)日：1981-08-04

申请号：CA318498

申请日：1978-12-22

Applicant: HOECHST AG

Inventor： BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  REDEN JUERGEN ,  SELIGER HUBERT

IPC: C07D417/12 ,  C07D499/00 ,  C07D499/12 ,  C07D499/44 ,  C07D501/06 ,  C07D501/20

Abstract: Process for acylating 6-amino-penam and 7-amino-cephem derivatives by activating the acylating component with an optionally substituted 1-hydroxybenzotriazole and then reacting the activated derivative with the 6-amino-penam or 7-amino-cepham derivative.

公开(公告)号：AU3507178A

公开(公告)日：1979-10-18

申请号：AU3507178

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：NO781322L

公开(公告)日：1978-10-17

申请号：NO781322

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06 ,  C07D

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：AU613164B2

公开(公告)日：1991-07-25

申请号：AU3153289

申请日：1989-03-21

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DURCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：PT90065A

公开(公告)日：1989-11-10

申请号：PT9006589

申请日：1989-03-21

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  ISERT DIETER ,  SEIBERT GERHARD ,  MENCKE BURGHARD ,  FISCHER GERD ,  KLESEL NORBERT ,  SELIGER HUBERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.