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公开(公告)号：AU2008331824B2
公开(公告)日：2014-07-24
申请号：AU2008331824
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： FLUSBERG BENJAMIN , EID JOHN , OTTO GEOFF , KORLACH JONAS , ROITMAN DANIEL , HARDENBOL PAUL
IPC: G01N33/53 , G01N33/535 , G01N33/573
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
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公开(公告)号：AU2012216605B2
公开(公告)日：2014-06-12
申请号：AU2012216605
申请日：2012-09-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：WO2009073201A2
公开(公告)日：2009-06-11
申请号：PCT/US2008013363
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
Inventor： KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
IPC: G01N33/573 , G01N33/53
CPC classification number: G01N33/54373 , C12Q1/6874 , G01N33/542 , G01N33/54313 , G01N33/573 , G01N33/58 , G01N33/585 , C12Q2565/607 , C12Q2565/531 , C12Q2563/143 , C12Q2563/137
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
Abstract translation: 描述了增强荧光标记策略的系统和方法以及使用非荧光和/或非光学标记策略的系统和方法，例如与使用ZMW的单分子测序一样。
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公开(公告)号：WO2007076057A3
公开(公告)日：2008-06-26
申请号：PCT/US2006049122
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
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公开(公告)号：WO2008121375A2
公开(公告)日：2008-10-09
申请号：PCT/US2008004149
申请日：2008-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , ROITMAN DANIEL BERNARDO , OTTO GEOFF , CICERO RONALD L , HOLCOMB NELSON R
Inventor： ROITMAN DANIEL BERNARDO , OTTO GEOFF , CICERO RONALD L , HOLCOMB NELSON R
CPC classification number: C12N11/14 , C07B2200/11 , C40B50/14 , Y10T428/31504 , Y10T428/31678
Abstract: Modified surfaces, substrates, and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide either non- reactive surfaces or low density reactive groups, preferably on an otherwise non-reactive surface, for use in different applications including single molecule analyses.
Abstract translation: 提供了改进的表面，基底以及制造和使用这些基底和表面的方法。 基底和表面提供非反应性表面或低密度反应性基团，优选在非反应性表面上，用于不同应用，包括单分子分析。
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Patent Agency Ranking16.发明申请PROTEIN ENGINEERING STRATEGIES TO OPTIMIZE ACTIVITY OF SURFACE ATTACHED PROTEINS 审中-公开蛋白质工程策略优化表面附着蛋白的活性
公开(公告)号：WO2007075873A3
公开(公告)日：2007-11-29
申请号：PCT/US2006048764
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12N9/22 , C07K2319/21 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/31663 , Y10T428/31768
Abstract: Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
Abstract translation: 提供了包括表面结合结构域，具有与其结合的活性酶的表面和将酶偶联到表面的方法的分离和/或重组酶。 酶可以包括用于表面偶联的大和/或多个表面偶联域。
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公开(公告)号：CA2645758C
公开(公告)日：2016-08-09
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：CA2719747A1
公开(公告)日：2009-10-01
申请号：CA2719747
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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公开(公告)号：CA2707600A1
公开(公告)日：2009-06-11
申请号：CA2707600
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
IPC: G01N33/573 , G01N33/53 , G01N33/535
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
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公开(公告)号：AU2006331677A1
公开(公告)日：2007-07-05
申请号：AU2006331677
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID , KORLACH JONAS , HANZEL DAVID , PHAM THANG , OTTO GEOFF , TURNER STEPHEN , PELUSO PAUL
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