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公开(公告)号：EP2265590A4
公开(公告)日：2012-04-25
申请号：EP09733489
申请日：2009-04-15
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
IPC: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14
CPC classification number: A61K45/06 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/5377 , C07D207/337 , C07D209/08 , C07D209/12 , C07D209/14 , C07D235/06 , C07D307/79 , C07D307/80 , C07D333/54 , C07D333/56 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D471/04
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
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12.发明公开CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 审中-公开ZIMTSÄUREHYDROXYAMIDEAS蛋白去乙酰化酶8的抑制剂
公开(公告)号：EP2797875A4
公开(公告)日：2015-09-02
申请号：EP12863933
申请日：2012-12-19
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , CHEN WEI , BALASUBRAMANIAN SRIRAM
IPC: C07C259/06 , A61K31/165 , A61P43/00 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06 , C07D405/06
CPC classification number: C07D405/06 , C07C235/34 , C07C235/38 , C07C259/06 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06
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公开(公告)号：EP2089391A4
公开(公告)日：2010-03-17
申请号：EP07867362
申请日：2007-11-05
Applicant: PHARMACYCLICS INC
Inventor： PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
IPC: C07D487/00 , C07D487/04 , G01N33/573
CPC classification number: C07D487/04 , G01N33/573 , G01N2333/9121 , G01N2500/00
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公开(公告)号：EP2393816A4
公开(公告)日：2011-12-14
申请号：EP10823966
申请日：2010-10-12
Applicant: PHARMACYCLICS INC
Inventor： CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
IPC: C07D487/04 , A61K31/519 , A61P19/02 , A61P19/10 , C07D401/04 , C07D401/14
CPC classification number: C07D487/04 , C07D519/00
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15.发明公开INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS 有权BRUTON TYROSINE KINASE HEMMER治疗实体肿瘤
公开(公告)号：EP2307025A4
公开(公告)日：2011-11-30
申请号：EP09798770
申请日：2009-07-16
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/00 , A61K31/519 , A61P35/00
CPC classification number: A61K31/519 , A61K31/00 , A61K31/337 , A61K31/52 , A61K31/675 , A61K31/704 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61K31/19
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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Patent Agency Ranking
公开(公告)号：EP2139487A4
公开(公告)日：2010-04-21
申请号：EP08744513
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
CPC classification number: C07D487/04 , A61K31/52 , C07D471/04 , C12Q1/485 , G01N33/57426 , G01N2440/14 , G01N2500/00
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公开(公告)号：EP2081435A4
公开(公告)日：2010-03-17
申请号：EP06850039
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , PAN ZHENGYING
IPC: A01N43/90 , A61K31/519 , A61P35/00 , C07D487/04
CPC classification number: A61K31/52 , A61K9/4825 , A61K31/00 , A61K31/519 , A61K39/3955 , A61K45/06 , C07D487/04 , C07K16/2887 , C07K2317/24 , A61K2300/00
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described arc irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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公开(公告)号：HUE025459T2
公开(公告)日：2016-05-30
申请号：HUE12166301
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , PAN ZHENGYING , MODY TARAK
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公开(公告)号：SG10201506776RA
公开(公告)日：2015-10-29
申请号：SG10201506776R
申请日：2010-10-12
Applicant: PHARMACYCLICS INC
Inventor： CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
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公开(公告)号：PT2526933E
公开(公告)日：2015-06-23
申请号：PT12166301
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK
IPC: A61K31/00 , A61K31/519 , A61P35/00 , A61P35/02 , C07D487/04
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