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公开(公告)号：WO2007075895A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048802
申请日：2006-12-21
Applicant: VERTEX PHARMA , WILSON DEAN , FANNING LEV T D , SHETH URVI , MARTINBOROUGH ESTHER , TERMIN ANDREAS , NEUBERT TIMOTHY , ZIMMERMANN NICOLE , KNOLL TARA , WHITNEY TARA , KAWATKAR AARTI , LEHSTEN DANIELLE , STAMOS DEAN , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , GUTIERREZ COREY
Inventor： WILSON DEAN , FANNING LEV T D , SHETH URVI , MARTINBOROUGH ESTHER , TERMIN ANDREAS , NEUBERT TIMOTHY , ZIMMERMANN NICOLE , KNOLL TARA , WHITNEY TARA , KAWATKAR AARTI , LEHSTEN DANIELLE , STAMOS DEAN , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , GUTIERREZ COREY
CPC classification number: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2006002421A3
公开(公告)日：2006-09-21
申请号：PCT/US2005022768
申请日：2005-06-24
Applicant: VERTEX PHARMA , HADIDA RUAH SARAH S , HAZLEWOOD ANNA R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , SINGH ASHVANI K , ZHOU JINGLAN , MCCARTNEY JASON
Inventor： HADIDA RUAH SARAH S , HAZLEWOOD ANNA R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , SINGH ASHVANI K , ZHOU JINGLAN , MCCARTNEY JASON
IPC: C07D401/12 , A61K31/47 , A61K31/4709 , A61P25/00 , A61P31/00 , C07C215/76 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D215/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC classification number: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：CO2024015816A2
公开(公告)日：2024-11-28
申请号：CO2024015816
申请日：2024-11-21
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , ZHOU JINGLAN , PATEL URVI , CHUDYK EWA IWONA , HURLEY DENNIS JAMES , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , DEMORET ROBERT MARTIN , VALIULIN ROMAN ASKATOVICH , KINTZER ALEXANDER FREDERIK , SLOCHOWER DAVID ROBERT , AERTGEERTS KATHLEEN , BECK ELIZABETH MARY , KNEGTEL RONALD MARCELLUS ALPHONSUS , NESAN SAVARIAR ELAMPRAKASH , WEBB PETER , GULEVICH ANTON V , ISHIHARA YOSHIHIRO , TRAN JOE A , SCHARF ADAM
IPC: A61P9/06 , A61K31/4375 , A61K31/47 , A61P25/02 , A61P29/00 , C07D215/233 , C07D401/04 , C07D471/04 , C07D519/00
Abstract: Se proporcionan compuestos, y sales farmacéuticamente aceptables de estos, útiles como inhibidores de canales de sodio. También se proporcionan composiciones farmacéuticas que comprenden los compuestos o sales farmacéuticamente aceptables y métodos de uso de los compuestos, sales farmacéuticamente aceptables y composiciones farmacéuticas en el tratamiento de diversos trastornos, incluido el dolor.
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公开(公告)号：AU2023215372A1
公开(公告)日：2024-08-22
申请号：AU2023215372
申请日：2023-02-02
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL TIMOTHY , BAEK MINSON , GAGNON KEVIN , MACK DANIEL JAMES , MEDEK ALES , PERESYPKIN ANDREY , ROEPER STEFANIE , SHRESTHA MUNA , SIESEL DAVID A , ZHOU JINGLAN , SHI YI
IPC: C07D498/14 , A61K31/437 , A61P11/00 , C07D213/81 , C07D413/04
Abstract: Processes and methods of preparing Compound (I) are disclosed. Crystalline forms of Compound (I), pharmaceutically acceptable salts, solvates, hydrates, and cocrystals thereof, pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：SI4013741T1
公开(公告)日：2024-06-28
申请号：SI202030439
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL , COCHRAN JOHN E , LITTLER BENJAMIN J , SIESEL DAVID ANDREW , URBINA ARMANDO , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D207/00 , C07D213/00 , C07D231/00 , C07D401/00 , C07D513/00
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Patent Agency Ranking16.发明专利
公开(公告)号：ES2968810T3
公开(公告)日：2024-05-14
申请号：ES20722087
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Se describen el compuesto (I), derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los anteriores. También se describen métodos para tratar la fibrosis quística usando estos compuestos. (Traducción automática con Google Translate, sin valor legal)
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公开(公告)号：HRP20231639T1
公开(公告)日：2024-03-15
申请号：HRP20231639
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
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公开(公告)号：CO2022002749A2
公开(公告)日：2022-06-21
申请号：CO2022002749
申请日：2022-03-09
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER (DECEASED) , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , ISHIHARA YOSHIHIRO , UY JOHNNY , BOOKSER BRETT C , BUSCH BRETT B , GHIRMAI SENAIT G , GULEVICH ANTON V , KHATUYA HARIPADA , TERMIN ANDREAS , VOGEL CARL V
IPC: C07D513/22 , A61K31/435 , A61P11/00
Abstract: Esta descripción proporciona moduladores del regulador de la conductancia transmembrana de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos un modulador de este tipo, métodos de tratamiento de la fibrosis quística mediante el uso de dichos moduladores y composiciones farmacéuticas, y procesos para fabricar dichos moduladores.
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公开(公告)号：CO2022002637A2
公开(公告)日：2022-06-21
申请号：CO2022002637
申请日：2022-03-04
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER (DECEASED) , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN , ANGELL PAUL , COCHRAN JOHN E , LITTLER BENJAMIN J , SIESEL DAVID ANDREW , URBINA ARMANDO
IPC: C07D207/08 , C07D207/09 , C07D213/61 , C07D213/62 , C07D213/70 , C07D213/74 , C07D231/20 , C07D401/04 , C07D401/14 , C07D513/22
Abstract: La descripción proporciona procesos para sintetizar el compuesto I, y sales farmacéuticamente aceptables del mismo. Compuesto I
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公开(公告)号：MX2022001829A
公开(公告)日：2022-06-08
申请号：MX2022001829
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ZHOU JINGLAN , COCHRAN JOHN E , ANGELL PAUL , URBINA ARMANDO , MCCARTNEY JASON , PARASELLI PRASUNA , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , HADIDA RUAH SARA SABINA , LITTLER BENJAMIN J , ANDERSON COREY DON , FRIEMAN BRYAN , PIERRE FABRICE , SWIFT SARA E , GROOTENHUIS (FALLECIDO) PETER , SIESEL DAVID
IPC: C07D207/08 , C07D207/09 , C07D213/61 , C07D213/62 , C07D213/70 , C07D213/74 , C07D231/20 , C07D401/04 , C07D401/14 , C07D513/22
Abstract: La descripción proporciona procesos para sintetizar el compuesto I, y sales farmacéuticamente aceptables del mismo.(Ver formula I).
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