公开(公告)号：DE59507973D1

公开(公告)日：2000-04-13

申请号：DE59507973

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：ES2135790T3

公开(公告)日：1999-11-01

申请号：ES95943203

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：AU711852B2

公开(公告)日：1999-10-21

申请号：AU1541697

申请日：1997-01-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：EA000434B1

公开(公告)日：1999-08-26

申请号：EA199700247

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

公开(公告)号：AU706859B2

公开(公告)日：1999-06-24

申请号：AU7491296

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CZ9900829A3

公开(公告)日：1999-06-16

申请号：CZ82999

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

公开(公告)号：MX9801988A

公开(公告)日：1998-08-30

申请号：MX9801988

申请日：1998-03-13

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: La presente invencion se refiere a las formas de medicamentos solidos obtenibles por extrusion con el posterior formado de una masa fundida sin solvente, que contiene, además de uno o más ingredientes activos, A) 2-90% en peso de un polímero procesable por fusion, soluble en agua, B) 5-89-9% en peso de isomalta, y C) 0-5% en peso de lecitina, en donde el total de todos los ingredientes es igual a 100% en peso.

公开(公告)号：HUT77625A

公开(公告)日：1998-06-29

申请号：HU9800064

申请日：1995-12-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  MAIER WERNER ,  ROSENBERG JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：HU9702424A2

公开(公告)日：1998-06-29

申请号：HU9702424

申请日：1996-02-01

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：MX9605678A

公开(公告)日：1998-04-30

申请号：MX9605678

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: Un procedimiento para producir composiciones de sustancia activa en forma de una solucion solida de la sustancia activa en una matriz de polímero, que comprende la extrusion en fusion de la sustancia activa en una forma no ionica junto con un polímero y una sal.