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    METHOD FOR DETECTING INTERACTIONS BETWEEN TWO AND MORE BIOLOGICAL MACROMOLECULES
    232.
    发明申请
    METHOD FOR DETECTING INTERACTIONS BETWEEN TWO AND MORE BIOLOGICAL MACROMOLECULES 有权
    用于检测两种和更多生物大分子之间相互作用的方法

    公开(公告)号：US20130130273A1

    公开(公告)日：2013-05-23

    申请号：US13733687

    申请日：2013-01-03

    Applicant: Korea Basic Science Institute

    Inventor： Zee Won Lee ,  Soo Hyun Kim

    IPC: C12Q1/02 ,  G01N33/53

    CPC classification number: C12Q1/025 ,  C07K2319/01 ,  C07K2319/60 ,  C12N15/1055 ,  G01N33/5035 ,  G01N33/542 ,  G01N33/557

    Abstract: Disclosed is a novel method for detecting interactions of biomolecules. More particularly, the disclosed method includes (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the second construct in the cell. the present invention provides a method capable of detecting bindings and interactions occurring in a living cell in real time, and a method for screening a material that alters the binding and the interaction. The method of the present invention overcomes the disadvantages including inaccuracy and complexity of existing biomaterial interaction detection techniques. By labeling both constructs to promote accuracy, the present invention provides a novel real-time, antibody-free analysis.

    Abstract translation: 公开了一种检测生物分子相互作用的新方法。 更具体地，所公开的方法包括（a）制备细胞，其包括（i）包含诱饵，第一标记材料和易位模块的第一构建体; 和（ii）包含猎物和第二标签材料的第二构建体; （b）检测细胞中第一构建体和第二构建体的分布。 本发明提供能够实时检测活细胞中发生的结合和相互作用的方法，以及筛选改变结合和相互作用的材料的方法。 本发明的方法克服了现有生物材料相互作用检测技术的不准确性和复杂性的缺点。 通过标记两种构建体以促进准确性，本发明提供了一种新颖的实时抗体免疫分析。

    HYDROPHILIC PARTICLES, METHOD FOR PRODUCING SAME, AND CONTRAST AGENT UTILIZING SAME
    236.
    发明公开
    HYDROPHILIC PARTICLES, METHOD FOR PRODUCING SAME, AND CONTRAST AGENT UTILIZING SAME 审中-公开
    亲水粒子，其制备方法以及使用该粒子的对比剂

    公开(公告)号：EP3308802A1

    公开(公告)日：2018-04-18

    申请号：EP16807715.4

    申请日：2016-05-19

    Applicant: Korea Basic Science Institute ,  Korea Research Institute of Chemical Technology

    Inventor： HONG, Kwan Soo ,  PARK, Hye Sun ,  NAM, Sang Hwan ,  SUH, Yung Doug

    IPC: A61K49/04 ,  A61K49/06

    Abstract: Provided are a hydrophilic particle, a method for manufacturing the same, and a contrasting agent using the same. More specifically, the hydrophilic particle according to the inventive concept may include a hydrophobic particle, and an amphiphilic organic dye directly absorbed on a surface of the hydrophobic particle. In this case, the hydrophobic particle includes a center particle, and a hydrophobic ligand covering a surface of the center particle, and the amphiphilic organic dye may be combined to the hydrophobic ligand by a hydrophobic interaction. The hydrophilic particle may have a surface zeta potential lower than a surface zeta potential of the amphiphilic organic dye.

    Abstract translation: 提供亲水性颗粒，其制造方法和使用其的对比剂。 更具体地，根据本发明构思的亲水颗粒可以包括疏水颗粒和直接吸附在疏水颗粒表面上的两亲有机染料。 在这种情况下，疏水性颗粒包括中心颗粒和覆盖中心颗粒表面的疏水性配体，并且两亲性有机染料可以通过疏水性相互作用与疏水性配体结合。 亲水性颗粒可具有低于两亲有机染料的表面ζ电位的表面ζ电位。

    NEUTRAL PARTICLE BEAM SOURCE INCLUDING BELT-TYPE MAGNETS AND MICROWAVE IRRADIATING EQUIPMENT
    237.
    发明公开
    NEUTRAL PARTICLE BEAM SOURCE INCLUDING BELT-TYPE MAGNETS AND MICROWAVE IRRADIATING EQUIPMENT 审中-公开
    美国麻醉科学研究所麻省理工学院EINEMBANDFÖRMIGENMAGNETEN UND MIKROWELLEN PLASMAQUELLE

    公开(公告)号：EP3002996A1

    公开(公告)日：2016-04-06

    申请号：EP15191835.6

    申请日：2012-06-01

    Applicant: Korea Basic Science Institute

    Inventor： YOO, Suk Jae ,  KIM, Seong Bong

    IPC: H05H1/46 ,  H01L21/205 ,  C23C16/50 ,  H01J37/32 ,  H01J37/34

    Abstract: The present invention is about a neutral particle beam source for producing a high density plasma in high vacuum and a thin film deposition system employing said neutral particle beam source,
    According to the present invention, the plasma is generated by using microwave through the microwave irradiating equipment and a magnetic field by more than one pair of belt type magnets and the high density plasma can be accomplished by maximizing the plasma confinement effect inducing an electron returning trajectory in accordance with the above continuous structure of the belt type magnet in combination with the microwave irradiating equipment.

    Abstract translation: 本发明涉及一种用于在高真空中制造高密度等离子体的中性粒子束源和采用所述中性粒子束源的薄膜沉积系统。根据本发明，通过使用微波通过微波照射设备产生等离子体 并且通过多于一对带式磁体的磁场和高密度等离子体可以通过根据带式磁体的上述连续结构最大化引起电子返回轨迹的等离子体约束效应与微波照射 设备。

    POWDER PLASMA TREATMENT APPARATUS
    238.
    发明公开
    POWDER PLASMA TREATMENT APPARATUS 有权
    粉末等离子体处理装置

    公开(公告)号：EP2929932A1

    公开(公告)日：2015-10-14

    申请号：EP13862200.6

    申请日：2013-12-06

    Applicant: Korea Basic Science Institute

    Inventor： SEOK, Dong Chan ,  JUNG, Yong Ho ,  JEONG, Hyun Young

    IPC: B01J19/08 ,  B01J2/00 ,  H05H1/42

    CPC classification number: H01J37/32532 ,  B01J19/088 ,  B01J2219/083 ,  B01J2219/0879 ,  H01J37/32009 ,  H01J37/32348 ,  H01J37/32568 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/2431

    Abstract: A powder plasma processing apparatus is disclosed. The powder plasma processing apparatus is a powder plasma processing apparatus of a cylindrical surface discharge plasma module, and the apparatus includes a plate-like electrode layer serving as an external surface of the cylindrical surface discharge plasma module, an insulating layer disposed on an internal surface of the plate-like electrode layer, and a plasma generating electrode disposed on the insulating layer, wherein the cylindrical surface discharge plasma module rotates, an alternating voltage is applied to the plasma generating electrode and the plate-like electrode layer to generate plasma around the plasma generating electrode, and a powder for plasma processing is processed by the plasma within the cylindrical surface discharge plasma module.

    Abstract translation: 公开了一种粉末等离子体处理设备。 粉末等离子体处理装置是圆筒形表面放电等离子体模块的粉末等离子体处理装置，并且该装置包括用作圆柱形表面放电等离子体模块的外表面的板状电极层，设置在内表面上的绝缘层 以及设置在所述绝缘层上的等离子体产生电极，其中所述圆柱形表面放电等离子体模块旋转，交流电压施加到所述等离子体产生电极和所述板状电极层，以在所述等离子体产生电极和所述板状电极层周围产生等离子体 等离子体产生电极和用于等离子体处理的粉末由圆柱面放电等离子体模块内的等离子体处理。

    METHOD FOR DETECTING COMPOUND-BINDING PROTEIN
    240.
    发明公开
    METHOD FOR DETECTING COMPOUND-BINDING PROTEIN 有权
    检测方法的涉及的化合物结合蛋白

    公开(公告)号：EP2799551A1

    公开(公告)日：2014-11-05

    申请号：EP12860693.6

    申请日：2012-12-20

    Applicant: Korea Basic Science Institute

    Inventor： LEE, Zee-Won ,  KIM, Soohyun ,  KIM, Seung II ,  HWANG, Jung Me

    IPC: C12N15/63 ,  C12N9/12 ,  C12N5/10 ,  G01N33/52

    CPC classification number: G01N33/5035 ,  C12N15/1055 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/581 ,  G01N33/582 ,  G01N2333/90666 ,  G01N2333/912 ,  G01N2500/02 ,  G01N2500/10

    Abstract: The present invention relates to a method for detecting the interactions of biomaterials, and more specifically, to a method for screening a prey which interacts with a bait, the method including: (a) preparing a cell which expresses (i) a first construct comprising a translocation module, a first labeling material, and a first medium, and (ii) a third construct comprising a prey and a second labeling material; (b) introducing (iii) a second construct into the prepared cell, the second construct comprising a bait and a second medium binding with the first medium; (c) allowing the prey and the bait to interact each other; and (d) confirming the interaction between the prey and the bait by detecting intracellular distributions of the first construct and the third construct. Further, the present invention relates to a cell expressing the first construct and the third construct. Still further, the present invention relates to a screening kit comprising the cell and the second construct. The methods of the present invention can overcome disadvantages including inaccuracy and complexity of the existing techniques for biomaterial interaction detection, and can measure the interaction between a material which is not directly produced through gene translation and gene expression in the cell and a material expressed in the cell, and thus are effective in detecting interactions of a broad range of biomaterials.

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