公开(公告)号：EP2309130B1

公开(公告)日：2016-08-10

申请号：EP10180441.7

申请日：2000-06-27

Applicant: California Institute of Technology

Inventor： Unger, Marc A. ,  Scherer, Axel ,  Quake, Stephen R. ,  Chou, Hou-Pu ,  Thorsen, Todd A.

IPC: F04B43/04 ,  F15C5/00 ,  F16K99/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

公开(公告)号：EP3030286A1

公开(公告)日：2016-06-15

申请号：EP14761437.4

申请日：2014-08-05

Applicant: Cam Med LLC

Inventor： QIN, Yanzhe ,  GE, Zhifei

IPC: A61M5/145 ,  A61K9/00 ,  F04B43/04 ,  A61M5/142 ,  F16K99/00

CPC classification number: A61M5/14248 ,  A61M5/14586 ,  A61M5/16881 ,  A61M39/24 ,  A61M2005/14252 ,  A61M2205/3334 ,  A61M2205/35 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2207/00 ,  B29C65/08 ,  B29C65/4825 ,  B29C66/301 ,  B29C66/474 ,  B32B37/12 ,  B32B2535/00 ,  B81B2201/036 ,  B81C1/00158 ,  B81C2201/034 ,  F04B43/043 ,  F04B53/10 ,  F16K2099/008 ,  F16K2099/0094

Abstract: A flexible patch pump for controllable accurate subcutaneous delivery of one or more medicaments to a patient includes a laminated layered structure. The pump may have a rigid reservoir layer including a number of rigid reservoirs disposed in a flexible material; a flexible microfluidic layer including a compliant membrane for sealing the rigid reservoirs, a network of microfluidic channels connecting the rigid reservoirs, and a number of inlet and/or outlet valves corresponding to the rigid reservoirs; and a flexible-rigid electronic circuit layer including a number of individually-addressable actuators. In operation, the rigid reservoirs may contain medicament that is dispensed in precise volumes at appropriate times due, for example, to a pressure change in an addressed reservoir caused by displacement of the compliant membrane or other actuation element.

Abstract translation: 用于将一种或多种药物可控地精确皮下递送给患者的柔性贴剂泵包括层压层状结构。 该泵可以具有刚性储存​​层，其包括设置在柔性材料中的多个刚性储存器; 柔性微流体层，包括用于密封刚性储存器的顺应性膜，连接刚性储存器的微流体通道网络和对应于刚性贮存器的多个入口和/或出口阀; 以及包括多个单独寻址的致动器的柔性刚性电子电路层。 在操作中，刚性贮存器可以包含在适当的时间以精确的体积分配的药物，例如由于顺应性膜或其它致动元件的位移引起的在寻址的贮存器中的压力变化。

公开(公告)号：EP2727146A4

公开(公告)日：2015-09-23

申请号：EP12805018

申请日：2012-06-29

Applicant: MURATA ELECTRONICS OY

Inventor： KUISMA HEIKKI

IPC: H01L25/18 ,  B81C1/00 ,  G01L19/00 ,  G01L19/14 ,  G01P1/02 ,  H01L23/538 ,  H01L25/16

CPC classification number: B81B7/0074 ,  B81B2201/0235 ,  B81B2201/025 ,  B81B2201/0257 ,  B81B2201/0264 ,  B81B2201/036 ,  B81B2207/012 ,  B81B2207/095 ,  B81C1/00333 ,  G01C19/5783 ,  G01L19/0084 ,  G01L19/148 ,  G01P1/023 ,  G01P1/026 ,  G01P15/0802 ,  H01L21/568 ,  H01L23/528 ,  H01L23/5389 ,  H01L24/16 ,  H01L24/17 ,  H01L24/19 ,  H01L24/32 ,  H01L24/73 ,  H01L24/83 ,  H01L24/92 ,  H01L24/96 ,  H01L24/97 ,  H01L25/16 ,  H01L25/18 ,  H01L25/50 ,  H01L27/14618 ,  H01L2223/6677 ,  H01L2224/12105 ,  H01L2224/16145 ,  H01L2224/1703 ,  H01L2224/32145 ,  H01L2224/73204 ,  H01L2224/8312 ,  H01L2224/8319 ,  H01L2224/92125 ,  H01L2224/97 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/1461 ,  H01L2924/15311 ,  H01L2924/181 ,  H01L2924/18162 ,  H01L2224/81 ,  H01L2224/83 ,  H01L2924/00012 ,  H01L2924/00

Abstract: A method of making a system-in-package device, and a system-in-package device is disclosed. In the method, at least one first species die with predetermined dimensions, at least one second species die with predetermined dimensions, and at least one further component of the system-in-device is included in the system-in package device. At least one of the first and second species dies is selected for redimensioning, and material is added to at least one side of the selected die such that the added material and the selected die form a redimensioned die structure. A connecting layer is formed on the redimensioned die structure. The redimensioned die structure is dimensioned to allow mounting of the non-selected die and the at least one further component into contact with the redimensioned die structure via the connecting layer.

公开(公告)号：EP2499368A2

公开(公告)日：2012-09-19

申请号：EP10781481.6

申请日：2010-11-12

Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Inventor： FOUILLET, Yves ,  BALERAS, François ,  COCHET, Martine ,  MAUBERT, Sandrine

IPC: F04B43/04 ,  B81B1/00 ,  B81C1/00 ,  F04D33/00 ,  B81B3/00

CPC classification number: F04B43/046 ,  A61M5/14586 ,  B81B2201/036 ,  B81B2203/0127 ,  B81C1/00182 ,  B81C2201/0167 ,  B81C2201/019 ,  F04B43/02 ,  F04B43/043 ,  F05C2203/02 ,  F05C2203/06 ,  Y10T29/494

Abstract: A method for producing at least one deformable membrane micropump including a first substrate and a second substrate assembled together, the first substrate including at least one cavity and the second substrate including at least one deformable membrane arranged facing the cavity. In the method: the cavity is produced in the first substrate; then the first and second substrates are assembled together; then the deformable membrane is produced in the second substrate.

公开(公告)号：EP2491587A2

公开(公告)日：2012-08-29

申请号：EP10825528.2

申请日：2010-10-19

Applicant: The Regents Of The University Of Michigan

Inventor： HAQUE, Razi-ul ,  WISE, Kensall

IPC: H01L23/055 ,  H01L23/08

CPC classification number: C03C19/00 ,  B81B2201/036 ,  B81B2201/058 ,  B81C1/00095 ,  F04B19/006 ,  Y10T428/24479

Abstract: A method of embedding material in a glass substrate is provided. The method includes providing a glass composition and a mold substrate having a patterned surface defining a recess therein. The mold substrate is formed from a material having a higher reflow temperature than the glass composition. A surface wettability of the patterned surface is increased relative to the glass composition. At least a portion of the glass composition is flowed into the recess defined by the patterned surface of the mold substrate, followed by solidifying the glass composition to form a solidified glass layer. Material is removed from the solidified glass layer until a portion of the underlying patterned surface of the mold substrate is exposed with at least a portion of the mold substrate embedded in the solidified glass layer to thereby form the glass substrate having the material embedded therein.

公开(公告)号：EP2039940A3

公开(公告)日：2012-05-30

申请号：EP08158448.4

申请日：2008-06-18

Applicant: Honeywell International Inc.

Inventor： Yang, Wei

IPC: F04D17/12 ,  F04D17/16 ,  B81B5/00

CPC classification number: F04D17/168 ,  B81B3/0021 ,  B81B2201/034 ,  B81B2201/036 ,  B81B2203/056 ,  F04D17/127

Abstract: A radial turbomolecular vacuum pump that includes a rotor made from a silicon rotor surface comprising monolithically fabricated micro blades, and a stator made from a silicon stator surface comprising corresponding monolithically fabricated grooves. The micro blades and grooves are arranged in multiple rings, and the rotor and stator disks are placed in proximity, creating interdigitated stator and rotor blade rings. The interdigitated stator and rotor blade rings form a multi-stage compression in the radial direction.

公开(公告)号：EP1194693B1

公开(公告)日：2006-10-25

申请号：EP00943235.2

申请日：2000-06-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： UNGER, Marc, A. ,  CHOU, Hou-Pu ,  THORSEN, Todd, A. ,  SCHERER, Axel ,  QUAKE, Stephen, R.

IPC: F04B43/04 ,  F15C5/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising : forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Abstract translation: 一种制造用于微型泵或阀的弹性体结构的方法，包括：在第一微加工模具（10）的顶部上形成第一弹性体层，所述第一微加工模具（10）具有第一凸起突起（11） （21），沿着所述第一弹性体层（20）的底表面延伸; 在第二微加工模具的顶部上形成第二弹性体层（22），所述第二微加工模具具有第二凸起突起（13），所述第二凸起突起形成沿着所述第二弹性体层的底表面延伸的第二凹部（23） 第二弹性体层的表面到第一弹性体层的顶表面上，使得控制通道（30）形成在第一和第二弹性体层之间的第二凹部中; 以及将所述第一弹性体层定位在平面基底的顶部上，使得在所述第一弹性体层和所述平面基底之间的所述第一凹部中形成流动通道。

公开(公告)号：EP1345551A2

公开(公告)日：2003-09-24

申请号：EP01989783.4

申请日：2001-11-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： UNGER, Marc, A. ,  CHOU, Hou-Pu ,  THORSEN, Todd, A. ,  SCHERER, Axel ,  QUAKE, Stephen, R. ,  LIU, Jian ,  ADAMS, Mark, L. ,  HANSEN, Carl, L.

IPC: A61F2/00

CPC classification number: B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Abstract translation: 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有形成沿所述第二弹性体层的底表面延伸的第二凹槽的第二凸起突起; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道形成在第一和第二弹性体层之间的第二凹部中; 以及将所述第一弹性体层定位在平面基底的顶部上，使得在所述第一弹性体层和所述平面基底之间的所述第一凹部中形成流动通道。

公开(公告)号：EP1317625A1

公开(公告)日：2003-06-11

申请号：EP01968418.2

申请日：2001-08-31

Applicant: Advanced Sensor Technologies

Inventor： HOWER, Robert, W. ,  CANTOR, Hal, C. ,  MONDRO, Jason, R.

IPC: F04B35/02 ,  F16K31/122 ,  F16K7/04

CPC classification number: F04B19/006 ,  A61B5/0002 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1491 ,  A61B2560/0412 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/086 ,  B81B1/00 ,  B81B3/0024 ,  B81B2201/036 ,  B81B2201/054 ,  F04B43/046 ,  F15B2015/208 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0036 ,  F16K99/0061 ,  F16K2099/0069 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084

Abstract: According to the present invention, there is provided a micro-fluidic sensor system (6) including a micro-conduit (56) for carrying fluid therethrough having a flexible wall portion (18), at least one micro-fluidic actuator having a closed cavity, flexible mechanism defining a wall of the cavity (11) and flexible wall portion (18) of the micro-conduit for deflecting upon an application of pressure thereto, and expanding mechanism (14) disposed in the cavity for selectively expanding the cavity and thereby selectively flexing said expanding mechanism, and sensor mechanism in fluid communication with the micro-conduit for sensing the presence or absence of molecules. The present invention further provides for a micro-fluidic system for moving micro-fluid amounts including a micro-conduit and at least one micro-fluidic actuator in fluid communication with the micro-conduit.

公开(公告)号：EP1294635A1

公开(公告)日：2003-03-26

申请号：EP01927492.7

申请日：2001-05-02

Applicant: Silverbrook Research Pty. Limited

Inventor： SILVERBROOK, Kia,Silverbrook Research Pty Ltd

IPC: B81B3/00 ,  B81C1/00 ,  B41J2/045

CPC classification number: B41J2/1645 ,  B41J2/14427 ,  B41J2/1623 ,  B41J2/1626 ,  B41J2/1631 ,  B41J2/1639 ,  B41J2/1648 ,  B81B3/007 ,  B81B2201/031 ,  B81B2201/036 ,  B81B2201/052 ,  Y10T29/42 ,  Y10T29/49083 ,  Y10T29/49401

Abstract: A thermal bend actuator ( 6 ) is provided with a group of upper arms ( 23, 25, 26 ) and a group of lower arms ( 27, 28 ) which are non planar, so increasing the stiffness of the arms. The arms ( 23, 25, 26,27,28 ) may be spaced transversely of each other and do not overly each other in plan view, so enabling all arms to be formed by depositing a single layer of arm forming material