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公开(公告)号：KR101349185B1
公开(公告)日：2014-01-16
申请号：KR1020060121960
申请日：2006-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K31/045 , A61P3/04
Abstract: 본 발명은 지방대사 이상질환의 치료 및 예방용 약학 조성물에 관한 것으로, 화학식 1의 화합물을 유효성분으로 포함하는 본 발명의 약학 조성물은 인간 간세포에서 생체내 에너지 대사에 중요한 역할을 하는 아이소싸이트레이트 탈수소효소 3α (IDH3α) 프로모터와 카르니틴 팔미토일 트랜스퍼레이즈 1A (CPT1A) 프로모터의 활성을 증가시켜, 혈당 및 중성지방의 감소 및 결과적으로 체중의 감소를 가져오므로, 비만, 고지혈증, 당뇨병 등의 지방대사 이상질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020110138000A
公开(公告)日：2011-12-26
申请号：KR1020100058067
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/48
Abstract: PURPOSE: An antithrombotic composition containing colored bean extract and fraction thereof is provided to contain adenosine and to treat cardiovascular and cerebralvascular diseases and hypertension. CONSTITUTION: An antithrombotic composition contains colored bean extract isolated using water, C1-C5 alcohol, or mixture thereof and organic acid. The organic acid includes citric acid, acetic acid, butyric acid, palmitic acid, oxalic acid, tartaric acid, carboxylic acid, or sulfonic acid. The C1-C5 alcohol is methane, ethanol, isopropylalcohol, n-propyl alcohol, n-butanol, or isobutanol. A fraction of the extract is prepared by fractioning the alcohol extract of colored beans using a synthetic adsorption column containing polystylene and benzene polymers.
Abstract translation: 目的：提供含有彩色豆提取物及其级分的抗血栓形成组合物，用于含有腺苷并治疗心血管和脑血管疾病和高血压。 构成：抗血栓组合物含有使用水，C1-C5醇或其混合物和有机酸分离的有色豆提取物。 有机酸包括柠檬酸，乙酸，丁酸，棕榈酸，草酸，酒石酸，羧酸或磺酸。 C1-C5醇是甲烷，乙醇，异丙醇，正丙醇，正丁醇或异丁醇。 通过使用含有聚苯乙烯和苯聚合物的合成吸附塔对有色豆的醇提取物进行分级来制备提取物的一部分。
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公开(公告)号：KR1020100104275A
公开(公告)日：2010-09-29
申请号：KR1020090022588
申请日：2009-03-17
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A liver function improving composition and a food composition including thereof are provided to prevent side effects of the composition by using herb medicine components, and to secure the hangover curing effect. CONSTITUTION: A liver function improving composition contains 0.1~50 parts of steamed red ginseng extract by weight, and 0.1~50 parts of extract containing cornus officinalis, and schizandra chinensis, as active ingredients. The liver function improving composition additionally contains 0.1~50 parts of steamed red ginseng chips by weight.
Abstract translation: 目的：提供肝功能改善组合物和包含其的食品组合物，以通过使用草药组分来防止组合物的副作用，并确保宿醉固化效果。 构成：肝功能改善成分含有0.1〜50份蒸红参提取物，0.1〜50份含有枸杞和五味子五味子的提取物作为活性成分。 肝功能改善组合物另外含有0.1〜50份重量的蒸红参芯片。
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公开(公告)号：KR100892272B1
公开(公告)日：2009-04-09
申请号：KR1020070104898
申请日：2007-10-18
Applicant: (주)아모레퍼시픽
CPC classification number: A23L33/105 , A23L2/38 , A23L5/51 , A23L19/00 , A23V2002/00 , A23V2250/2112 , A23V2250/2124
Abstract: A diet composition containing ginseng extract and curcuma root extract is provided to maximize endurance capacity by improving storage content of glycogen and to use as health food. A diet composition contains 1~100 weight% of dry weight on the basis of total weight of ginseng extract and curcuma root extract. A method for manufacturing diet composition containing the ginseng extract and the curcuma root extract includes a step for filtering and concentrating the ginseng and the curcuma root, after extracting the curcuma root extract and the ginseng from water respectively and a step for mixing the ginseng extract and the curcuma root extract with a rate of 1:7~3:1.
Abstract translation: 提供含有人参提取物和姜黄根提取物的饮食组合物，通过改善糖原的储存含量并用作保健食品来最大限度地发挥耐力。 饮食组合物以人参提取物和姜黄根提取物的总重量为基准，含有1〜100重量％的干重。 制备含有人参提取物和姜黄根提取物的饮食组合物的方法包括：分别从水中提取姜黄根提取物和人参后对人参和姜黄根进行过滤和浓缩的步骤，以及将人参提取物和 姜黄提取物的比例为1：7〜3：1。
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25.发明公开2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용가능한 그의 염, 그의 제조방법 및 그를 유효성분으로함유하는 ＳＰＣ 수용체 활성으로 유발되는 염증관련 질환치료제 有权新的2,4,5-三唑-3-基噻唑衍生物及其药物可接受的盐，其制备方法，用于由含有2,4,5-三唑基-1,3-噻唑衍生物的SPC活性诱导的抗炎性疾病的治疗剂 有效的成分
公开(公告)号：KR1020090032372A
公开(公告)日：2009-04-01
申请号：KR1020070097553
申请日：2007-09-27
Inventor： 공영대 , 조희영 , 전문국 , 이태호 , 최길돈 , 공재양 , 정대영 , 황순희 , 김정주 , 이창훈 , 고재영 , 노민수 , 한은실 , 김형준 , 김혁 , 윤준원 , 모주현 , 김도훈
IPC: C07D277/44 , C07D417/04 , C07D417/12 , A61K31/426
CPC classification number: C07D277/46 , C07D417/04 , C07D417/12
Abstract: Provided is 2,4,5-trisubstituted-1,3-thiazole derivatives having excellent inhibiting activity about SPC(sphingosylphosphorylcholine) receptor to treat inflammatory diseases caused by activity of the SPC acceptor. A therapeutic agent for treating inflammatory diseases caused by activity of SPC acceptor comprises a 2,4,5-trisubstituted-1,3-thiazole derivative represented by the formula 1 and pharmaceutically allowable salts thereof. A method for preparing the 2,4,5-trisubstituted-1,3-thiazole derivative consists of the following steps of: reacting methyl cyanocarbonimidodithionate represented by the formula 2 to 2-haloacetophenone in order to synthesize 4-amino-1,3-thiazol represented by the formula 3; and polymerizing chloridation carboxylic acid to 4-amino group of the 4-amino-1,3-thiazol to synthesize 4-N-acyl-1,3-thiazole represented by the formula 4.
Abstract translation: 提供对SPC（鞘氨基磷酰胆碱）受体具有优异抑制活性的2,4,5-三取代-1,3-噻唑衍生物，用于治疗由SPC受体的活性引起的炎性疾病。 用于治疗由SPC受体的活性引起的炎性疾病的治疗剂包括由式1表示的2,4,5-三取代-1,3-噻唑衍生物及其药学上允许的盐。 制备2,4,5-三取代-1,3-噻唑衍生物的方法包括以下步骤：使由式2表示的氰基羰基亚氨基二硫代乙酸甲酯与2-卤代苯乙酮反应，以合成4-氨基-1,3- 由式3表示的噻唑; 并将氯化羧酸聚合成4-氨基-1,3-噻唑-4-氨基，合成由式4表示的4-N-酰基-1,3-噻唑。
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Patent Agency Ranking
公开(公告)号：KR1020080051239A
公开(公告)日：2008-06-11
申请号：KR1020060121960
申请日：2006-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K31/045 , A61P3/04
Abstract: A pharmaceutical composition comprising compounds capable of increasing expressions of isocitrate dehydrogenase 3alpha(IDH3alpha) and carnitine palmitoyl transferase 1A(CPT1A) by increasing activity of their promoters is provided to reduce synthesis of fatty acid and promote oxidation of fatty acid, so that the composition is useful for treating and preventing lipid metabolism-related diseases. A pharmaceutical composition for treating and preventing lipid metabolism-related diseases comprises compounds represented by the formula(1) in which R1 is adamantly group or phenyl group substituted by H, OH or C1-C5 alkyl, and R2 is CONH or NHCO, and further comprises pharmaceutically acceptable carriers, excipients or diluents selected from lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, crystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
Abstract translation: 提供了包含通过提高其启动子的活性而能够增加异柠檬酸脱氢酶3α（IDH3α）和肉碱棕榈酰转移酶1A（CPT1A）的表达的化合物的药物组合物，用于减少脂肪酸的合成并促进脂肪酸的氧化，使得组合物 用于治疗和预防脂质代谢相关疾病。 用于治疗和预防脂质代谢相关疾病的药物组合物包括由式（1）表示的化合物，其中R1是金刚烷基或被H，OH或C1-C5烷基取代的苯基，R2是CONH或NHCO， 包括药学上可接受的载体，赋形剂或稀释剂，其选自乳糖，葡萄糖，蔗糖，山梨糖醇，甘露糖醇，木糖醇，赤藓糖醇，麦芽糖醇，淀粉，阿拉伯胶，藻酸盐，明胶，磷酸钙，硅酸钙，纤维素，甲基纤维素，结晶纤维素，聚乙烯吡咯烷酮 ，水，羟基苯甲酸甲酯，羟基苯甲酸丙酯，滑石，硬脂酸镁和矿物油。
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公开(公告)号：KR100638137B1
公开(公告)日：2006-10-25
申请号：KR1020050016551
申请日：2005-02-28
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 유효성분으로 양지꽃 추출물을 함유하는 화장료 조성물에 관한 것이다. 보다 상세하게는, 본 발명의 화장료 조성물은 유효성분으로 양지꽃 추출물을 함유하여 피부에 대한 부작용 없이 안전하게 사용될 수 있을 뿐만 아니라, 세포내 항산화 방어인자 중 카탈라아제의 활성 보호능과 우수한 미백 및 보습 효과를 나타낸다.
양지꽃 * 카탈라아제 * 미백 * 보습 * 화장료-
公开(公告)号：KR1020160128277A
公开(公告)日：2016-11-07
申请号：KR1020160140904
申请日：2016-10-27
Applicant: (주)아모레퍼시픽
IPC: A61K36/48 , A23L33/105
Abstract: 본발명은유색콩등으로부터추출한유색콩추출물의분획물을유효성분으로함유하는항혈전효능조성물에관한것이다. 본발명에의한항혈전조성물은아데노신을포함하고있으며, 혈전형성의원인이되는심장혈관질환, 뇌혈관질환, 동맥경화증, 고혈압, 당뇨등의순환기계질환의치료에매우유용하게이용될수 있다.
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公开(公告)号：KR1020160073950A
公开(公告)日：2016-06-27
申请号：KR1020160071842
申请日：2016-06-09
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/48 , A23L33/105 , A23V2200/30 , A23V2200/326
Abstract: 본발명은유색콩등으로부터추출한유색콩추출물및 그분획물을유효성분으로함유하는항혈전효능조성물에관한것이다. 본발명에의한항혈전조성물은아데노신을포함하고있으며, 혈전형성의원인이되는심장혈관질환, 뇌혈관질환, 동맥경화증, 고혈압, 당뇨등의순환기계질환의치료에매우유용하게이용될수 있다.
Abstract translation: 本发明涉及抗紫外线组合物，其含有作为活性成分的从有色豆及其部分提取的有色豆提取物。 本发明的抗血栓形成组合物含有腺苷，可用于治疗血栓形成原因的心血管疾病，脑血管疾病，动脉粥样硬化，高血压，糖尿病等循环系统疾病。
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公开(公告)号：KR101210008B1
公开(公告)日：2012-12-07
申请号：KR1020050104962
申请日：2005-11-03
Applicant: (주)아모레퍼시픽
IPC: A61K31/685 , A61K31/66
Abstract: 본발명은스핑고실포스포릴콜린(Sphingosylphosphorylcholine; SPC) 또는그 유도체의용도에관한것으로서, 보다상세하게는상기스핑고실포스포릴콜린의투여량을조절하여동물에가려움을유발하는방법, 가려움증억제물질을스크리닝하는방법및 스크리닝한가려움증억제물질의약효를평가하는방법에관한것이다. 본발명에의한스핑고실포스포릴콜린또는그 유도체는가려움증을이해하고연구하는데유용하며, 이를바탕으로가려움증치료약을검색하거나약효를평가하여개발하는데매우유용하게사용될수 있다.
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