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21.发明公开
公开(公告)号：KR1020120077359A
公开(公告)日：2012-07-10
申请号：KR1020100139292
申请日：2010-12-30
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: C12Q1/689 , C12Q1/6837 , C12Q2525/107 , C12R1/445
Abstract: PURPOSE: A PNA microarray for identifying and diagnosing aerobic gram-positive food poisoning bacteria is provided to accurately and quickly diagnose Staphylococcus aureus and Listeria monocytogenes from other bacteria. CONSTITUTION: A PNA microarray for identifying and diagnosing aerobic gram-positive food poisoning bacteria contains a PNA(peptide nucleic acid) probe of sequence numbers 1 and 2 and a primer of sequence numbers 3-6. The aerobic gram-positive food poisoning bacteria include Staphylococcus aureus or Listeria monocytogenes.
Abstract translation: 目的：提供用于识别和诊断好氧革兰氏阳性食物中毒细菌的PNA微阵列，以准确和快速地诊断来自其他细菌的金黄色葡萄球菌和单核细胞增多性李斯特菌。 构成：用于鉴定和诊断需氧革兰氏阳性食物中毒细菌的PNA微阵列含有序列号1和2的PNA（肽核酸）探针和序列号3-6的引物。 需氧革兰氏阳性食物中毒细菌包括金黄色葡萄球菌或单核细胞增多性李斯特氏菌。
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公开(公告)号：KR1020110009638A
公开(公告)日：2011-01-28
申请号：KR1020100070745
申请日：2010-07-22
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A23K10/18 , A23K20/195 , C12N1/20 , C12R1/225
Abstract: PURPOSE: A feed additive composition including novel lactobacillus species lactobacillus mixed bacterial strain is provided to offer the excellent antibacterial activity and starch resolution function for various pathogenic bacteria. CONSTITUTION: A feed additive composition contains a lactobacillus mixed bacterial strain formed with lactobacillus johnsonii G22-2, lactobacillus reuteri G8-5, and lactobacillus salivarius G1-1. The lactobacillus mixed bacterial strain has the antimicrobial activity against pathogenic bacteria, the starch degradation capability, the acid resistance, the bile tolerance, and the intestine adhesion capability.
Abstract translation: 目的：提供包含新型乳酸杆菌种乳杆菌混合菌株的饲料添加剂组合物，为各种病原菌提供优异的抗菌活性和淀粉分解功能。 构成：饲料添加剂组合物含有由约翰逊乳杆菌G22-2，乳酸杆菌G8-5和唾液乳杆菌G1-1形成的乳杆菌混合菌株。 乳杆菌混合菌株对病原菌具有抗菌活性，淀粉降解能力，耐酸性，胆汁耐受性和肠粘连能力。
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公开(公告)号：KR1020110009516A
公开(公告)日：2011-01-28
申请号：KR1020090066955
申请日：2009-07-22
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: PURPOSE: A feed additive composition containing Lactobacillus salivarius G1-1 is provided to ensure antibacterial activity to various pathogenic bacteria and to be used as a probiotic composition. CONSTITUTION: A Lactobacillus salivarius G1-1 is deposited in KACC91449P. The Lactobacillus salivarius G1-1 has 16s rDNA of sequence number 1 and is isolated from porcine small intestine by pure culture. A feed additive composition contains the Lactobacillus salivarius G1-1 as an active ingredient. The feed additive suppresses in vivo proliferation of pathogenic bacteria.
Abstract translation: 目的：提供含有唾液乳杆菌G1-1的饲料添加剂组合物，以确保对各种病原菌的抗菌活性，并用作益生菌组合物。 构成：唾液乳杆菌G1-1保藏在KACC91449P中。 唾液乳杆菌G1-1具有序列1的16s rDNA，通过纯培养从猪小肠中分离。 饲料添加剂组合物含有唾液乳杆菌G1-1作为活性成分。 饲料添加剂抑制致病菌的体内增殖。
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公开(公告)号：KR100951055B1
公开(公告)日：2010-04-06
申请号：KR1020070093644
申请日：2007-09-14
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/344 , A61P37/02
Abstract: 본 발명은 동물의 면역능을 증강시키는 더덕 추출물 및 그 제조방법과 용도에 관한 것이다. 보다 상세하게는 더덕줄기 및 잎을 음지에서 건조시켜 마쇄하여 열탕용 봉지에 넣고 증류수 중에 가열하여 1차 추출한 후, 추출물은 별도로 분리하고 잔류물에 재차 증류수를 넣고 열탕하여 2차 추출하여 추출물을 얻는 단계와, 1차 및 2차 추출물을 혼합하여 추출물에 2배량의 에탄올을 가하여 4∼6℃ 냉장실에서 24시간 정치시켜 침전된 다당체를 원심분리하는 단계와, 분리된 다당체를 순수 에탄올로 원심 세척한 후 35∼38℃ 항온실에서 건조하여 증류수로 1mg/ml 농도로 용해시켜 세균여과지로 여과하여 원액을 얻는 단계로 구성된다.
본 발명의 더덕추출물은 동물의 주요 면역세포인 호중구의 각종 활성과 싸이토카인 생성을 증강시키고 병원성세균의 공격접종에 대한 비특이적인 방어능을 증진시키는 효과가 있으므로 동물용 의약품으로써 면역증강제. 백신보좌제 첨가물 그리고 보조치료제 등으로 광범위하게 활용될 수 있을 것이다.-
公开(公告)号：KR100918098B1
公开(公告)日：2009-09-24
申请号：KR1020070077854
申请日：2007-08-02
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/02 , A61P37/02 , A61K39/085
Abstract: 본 발명은 스트렙토마이세스 알부스 용균 추출물을 포함하는 백신 보좌제에 관한 것으로, 보다 자세히는 스트렙토마이세스 알부스(Streptomyces albus) 용균 추출물을 이용하여 동물의 면역 능력을 향상시키는 백신 보좌제에 관한 것으로, 동물의 주요 면역세포인 호중구 및 림프구 등의 활성을 증가시켜 병원성 세균의 공격에 대하여 면역 기능을 증진시키는 스트렙토마이세스 알부스(Streptomyces Albus) 용균 추출물을 포함하는 백신 보좌제를 제공하는 것을 목적으로 한다.
본 발명은 이와 같은 스트렙토마이세스 알부스로부터 추출한 용균 추출물을 이용하여 질병 방어에 주요한 역할을 담당하고 있는 각종 면역세포들의 기능을 증강시켜 질병 감염에 대한 특이 및 비특이적 저항성을 높여서, 질병으로부터 동물을 보호할 수 있는 효과를 제공한다.
스트렙토마이세스 알부스, 용균 추출물, 면역-
Patent Agency Ranking
公开(公告)号：KR1020080106789A
公开(公告)日：2008-12-09
申请号：KR1020070054645
申请日：2007-06-04
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/236 , A61P37/02
Abstract: A Glycyrrhiza hot water extract, a method for preparing the extract, and an immune enhance containing the extract are provided to improve the immune increasing activity of animals. A Glycyrrhiza hot water extract is prepared by adding 1,000 mL of distilled water per 100 g of the dried Glycyrrhiza to soak Glycyrrhiza for 20-30 min and boiling it down for 150 min to obtain an extract; adding 800 mL of distilled water per 100 g of the dried Glycyrrhiza to the Glycyrrhiza remaining after the extraction and boiling it down for 150 min to obtain an extract; adding 700 mL of distilled water per 100 g of the dried Glycyrrhiza to the Glycyrrhiza remaining after the extraction and boiling it down for 150 min to obtain an extract; collecting the obtained extract and concentrating it; and dry-freezing the concentrated one.
Abstract translation: 提供甘草热水提取物，制备提取物的方法和含有提取物的免疫增强物，以提高动物的免疫增加活性。 通过向100g甘草中加入1000mL蒸馏水，将Glycyrrhiza浸泡20-30分钟，煮沸150分钟，得到甘草热水提取物，得到提取物; 向100g甘草中加入800毫升蒸馏水，然后将其蒸馏除去150分钟，得到提取物; 向100g甘草中加入700毫升蒸馏水至提取后剩余的甘草，煮沸150分钟，得到提取物; 收集所得提取物并浓缩; 并干燥浓缩浓缩的。
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公开(公告)号：KR1020070104720A
公开(公告)日：2007-10-29
申请号：KR1020060036588
申请日：2006-04-24
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N1/20
Abstract: An Enterohemorrhagic Escherichia coli(EHEC) strain isolated from Korean native cattle is provided to be used as a vaccine strain. And a toxoid vaccine for preventing an infectious disease of EHEC comprising an inactivated Shiga toxin produced from the strain is provided to prevent hemorrhagic diarrhea of a calf and induce the decrease of the infection in cattle, thereby being ultimately used for preventing an infectious disease of EHEC. An EC377 strain selected from EHEC derived from Korean native cattle produces shigatoxins 1(stx1) and has a plasma type of 055. An EC611 strain selected from the EHEC derived from Korean native cattle produces stx2 and has a plasma type of 06. An EC381 strain selected from the EHEC derived from Korean native cattle produces stx1 and stx2 and has a plasma type of 0153. 06. 55. A method for promoting the generation of Shiga toxins is characterized in that 0.5-1.0mug/ml of Mitomycin C is added during the culturing of the EHEC strains. A toxoid vaccine for preventing an infectious disease of EHEC comprises at least one Shiga toxins cStx1 and cStx2 toxoid antigen prepared by treating the shigatoxins with 0.2-0.5% of glutaraldehyde for 1-3 hours and then detoxicating it with 0.2-1.0% of lysine.
Abstract translation: 提供从韩国本地牛分离的肠出血性大肠杆菌（EHEC）菌株用作疫苗株。 并提供一种用于预防由该菌株产生的包含灭活的志贺毒素的EHEC感染性疾病的类毒素疫苗，以防止小牛的出血性腹泻并诱导牛的感染减少，从而最终用于预防EHEC的感染性疾病 。 选自源自韩国本地牛的EHEC的EC377菌株产生了起始的黄曲霉毒素1（stx1），血浆类型为055.选自来自韩国本地牛的EHEC的EC611菌株产生stx2，血浆类型为0.06。EC381菌株 选自源自韩国本地牛的EHEC产生stx1和stx2，并具有等离子体类型0153. 06. 55.一种用于促进滋贺毒素生成的方法，其特征在于在0.5-10.0μg/ ml丝裂霉素C中加入 培养EHEC菌株。 用于预防EHEC传染病的类毒素疫苗包含至少一种通过用0.2-0.5％戊二醛处理志贺菌素1-3小时制备的志贺毒素cStx1和cStx2类毒素抗原，然后用0.2-1.0％的赖氨酸对其进行解毒。
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公开(公告)号：KR1020050117686A
公开(公告)日：2005-12-15
申请号：KR1020040042854
申请日：2004-06-11
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: G01N33/543
CPC classification number: G01N33/56916 , G01N33/581 , G01N2400/50
Abstract: 본 발명은 살모넬라 티피뮤리움(Salmonella typhimurium), 살모넬라 엠반다카(Salmonella mbandaca), 및 살모넬라 엔테라이티디스(Salmonella enteritidis)에서 추출한, 그룹특이성 및 민감성이 우수하고 항원성이 뛰어난 LPS(lipopolysaccaride)를 혼합하여 항원으로 사용하는 것을 특징으로 하는 동물의 살모넬라 감염항체 검사키트를 제공한다.
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公开(公告)号：KR1020000003286A
公开(公告)日：2000-01-15
申请号：KR1019980024503
申请日：1998-06-27
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12Q1/68
Abstract: PURPOSE: A multiplex polymerase chain reaction-based method is provided to quickly detect E. coli gene producing heat-labile enterotoxin and heat-stable enterotoxin, which cause diarrhea of live stock. CONSTITUTION: ST(heat-stable enterotoxin) I primer is synthesized to be based on the nucleotide sequence of ST I a(p) gene separated from a pig. A PCR method for detecting gene uses a pair of primers, a forward primer and a reverse primer. Heat-labile enterotoxin gene and heat-stable enterotoxin gene, which are separated from E.coli, are detected simultaneously by performing PCR with mixing PCR primers therefor.
Abstract translation: 目的：提供基于多重聚合酶链反应的方法，快速检测产生热不稳定肠毒素和热稳定肠毒素的大肠杆菌基因，引起活体腹泻。 构成：ST（热稳定肠毒素）I引物基于从猪分离的ST I a（p）基因的核苷酸序列合成。 用于检测基因的PCR方法使用一对引物，正向引物和反向引物。 通过用混合PCR引物进行PCR同时检测与大肠杆菌分离的热不稳定肠毒素基因和热稳定肠毒素基因。
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