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公开(公告)号：KR101818190B1
公开(公告)日：2018-01-12
申请号：KR1020160052290
申请日：2016-04-28
Applicant: 한국과학기술연구원
Abstract: 본발명은격막플라즈마장치를이용한나노금속산화물의제조방법에관한것으로, a) 금속전구체용액을제조하는단계, 및 b) 상기용액을반응기에투입하여플라즈마처리를하는단계를포함하며, 상기반응기는상기용액이채워지는제1 공간부와제2 공간부, 상기제1 공간부와제2 공간부사이에배치되는격벽, 상기제1 공간부와제2 공간부를연결하는제3 공간부, 및상기제1 공간부에구비되는제1 전극과상기제2 공간부에구비되는제2 전극을포함하는것을특징으로한다.
Abstract translation: 本发明涉及一种使用隔膜等离子体装置制备纳米金属氧化物的方法，其包括以下步骤：a）制备金属前体溶液，和b）将该溶液引入用于等离子体处理的反应器中， 第一空间部分和第二空间部分填充有溶液，分隔壁设置在第一空间部分和第二空间部分之间，第三空间部分连接第一空间部分和第二空间部分， 和设置在第二空间部分中的第二电极。
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公开(公告)号：KR100428703B1
公开(公告)日：2004-04-30
申请号：KR1020000005140
申请日：2000-02-02
Applicant: 한국과학기술연구원
IPC: C07D309/04
Abstract: PURPOSE: A novel macrolide compound having an inhibiting activity for the growth of Helicobacter pylori is provided, which is not easily decomposed by gastric acid. CONSTITUTION: The macrolide compound is represented by formula (1), in which R1 is hydrogen, 4-methoxy phenoxy methyl, 2-methoxy phenoxy methyl or methoxy ethoxy methyl; R2 is hydrogen, acyl or lower alkoxy; R3 is the same or different and hydrogen or acyl; and Q and W form oxo together or independently -OR4 and hydrogen, wherein R4 is hydrogen. It has an inhibiting activity for the growth of Helicobacter pylori which causes several stomach diseases.
Abstract translation: 目的：提供一种对幽门螺杆菌生长具有抑制活性的新型大环内酯化合物，其不易被胃酸分解。 构成：大环内酯类化合物由式（1）表示，其中R1为氢，4-甲氧基苯氧基甲基，2-甲氧基苯氧基甲基或甲氧基乙氧基甲基; R2是氢，酰基或低级烷氧基; R3相同或不同，为氢或酰基; 并且Q和W一起或独立地形成氧代-OR 4和氢，其中R 4是氢。 它对幽门螺杆菌的生长具有抑制活性，引起多种胃病。
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公开(公告)号：KR100377787B1
公开(公告)日：2003-03-26
申请号：KR1020000086254
申请日：2000-12-29
IPC: C07D471/04
Abstract: PURPOSE: Provided are novel pyridopyrimidine derivatives which inhibit phosphodiesterase IV activity and TNF production. Also, provided are preparing process thereof and a pharmaceutical composition containing the same. CONSTITUTION: The novel pyridopyrimidine derivative is represented by the formula(1), wherein R1 is C1-3 lower alkyl, C3-7 cycloalkyl, cycloalkyloxy, cycloalkyl amino, cycloalkyl lower alkyl, C1-3 lower alkoxy, formyl, hydroxy lower alkyl or carboxyalkyl; R is hydrogen, methyl, C3-7 lower alkyloxy, phenyl, benzyl, substituted phenyl(wherein a substituent group includes cyano, halogen, carboxylalkyl, nitro, methyl, trihalogenated ethyl or alkyloxy; and substitution site can be ortho-, meta-, or para- site), alkyloxy, C3-7 lower alkyloxy ethyl, benzyloxy, benzyloxyethyl, phenyloxyethyl, carboxyalkyl or cyano group; and R4 is hydrogen or methyl group, provided that R2 and R3 are not the same.
Abstract translation: 目的：提供抑制磷酸二酯酶IV活性和TNF产生的新型吡啶并嘧啶衍生物。 另外，提供了其制备方法和含有其的药物组合物。 构成：新的吡啶并嘧啶衍生物由式（1）表示，其中R1为C1-3低级烷基，C3-7环烷基，环烷氧基，环烷基氨基，环烷基低级烷基，C1-3低级烷氧基，甲酰基，羟基低级烷基或 羧基; （其中取代基包括氰基，卤素，羧基烷基，硝基，甲基，三卤代乙基或烷氧基;取代位置可以是邻位，间位， 烷氧基，C 3-7低级烷氧基乙基，苄氧基，苄氧基乙基，苯氧基乙基，羧基烷基或氰基; 并且R4是氢或甲基，条件是R2和R3不相同。
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公开(公告)号：KR100264156B1
公开(公告)日：2001-11-22
申请号：KR1019980002915
申请日：1998-02-03
Applicant: 한국과학기술연구원
IPC: C07D501/24
Abstract: PURPOSE: Provided is (E)-prophenyl quaternary ammonium cephem compound and a pharmaceutically acceptable salt and a method for preparation thereof. The prepared compound has excellent antibacterial activity against both gram positive and gram negative strains, and is thus used for Cephalosporin based medicines. CONSTITUTION: (E)-prophenyl quaternary ammonium cephem compound is represented by the formula(1), wherein R1 is hydrogen, formyl, t-buthoxycarbonyl, benzyloxycarbonyl, p-nitrobenzyloxycarbonyl or trithyl; R2 is hydrogen, methyl, 2-fluoroethyl, formyl, chloroacetyl, benzoyl, p-nitrobenzyl, 2,2,2-trichloroethoxycarbonly, tetrahydropyranyl or trithyl; R3 is hydrogen, group forming carboxylic salt, 2,2,2-trichloroethyl, p-methoxybenzyl, p-nitrobenzyl, benzhydryl or t-butyl; R4 is methoxy, carbamoyl having substituent, or C5 hetero ring substituent represented by oxydiazole or triazole; and n is an integer of 1 or 2.
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公开(公告)号：KR1020010077376A
公开(公告)日：2001-08-17
申请号：KR1020000005140
申请日：2000-02-02
Applicant: 한국과학기술연구원
IPC: C07D309/04
Abstract: PURPOSE: A novel macrolide compound having an inhibiting activity for the growth of Helicobacter pylori is provided, which is not easily decomposed by gastric acid. CONSTITUTION: The macrolide compound is represented by formula (1), in which R1 is hydrogen, 4-methoxy phenoxy methyl, 2-methoxy phenoxy methyl or methoxy ethoxy methyl; R2 is hydrogen, acyl or lower alkoxy; R3 is the same or different and hydrogen or acyl; and Q and W form oxo together or independently -OR4 and hydrogen, wherein R4 is hydrogen. It has an inhibiting activity for the growth of Helicobacter pylori which causes several stomach diseases.
Abstract translation: 目的：提供一种具有幽门螺杆菌生长抑制活性的新型大环内酯类化合物，不易被胃酸分解。 构成：大环内酯类化合物由式（1）表示，其中R1是氢，4-甲氧基苯氧基甲基，2-甲氧基苯氧基甲基或甲氧基乙氧基甲基; R2是氢，酰基或低级烷氧基; R3相同或不同，为氢或酰基; 并且Q和W一起或独立地代表-OR4和氢，其中R4是氢。 它对幽门螺杆菌的生长具有抑制作用，导致多种胃部疾病。
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Patent Agency Ranking
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公开(公告)号：KR101127163B1
公开(公告)日：2012-03-20
申请号：KR1020090006515
申请日：2009-01-28
Applicant: 한국과학기술연구원
Abstract: 본 발명은 신규 박테리아 균주 KME-002 및 이의 용도에 관한 것으로, 더욱 상세하게는 멍게로부터 분리한 해양 박테리아 균주 KME-002의 유전자 형태 및 생화학적 성상을 분석하여 신규 박테리아 균주임이 밝혀졌으며, 상기 균주가 담즙의 주성분인 콜린산(cholic acid) 유도체 중 7-케토데옥시콜린산(7-ketodexoycholic acid) 및 3-옥소데옥시콜린산(3-Oxodeoxycholic acid)를 생산하고, 양식 멍게에게 일명 조그랑증 및 물렁증 등의 질병을 유발하는 원인균임이 밝혀짐으로써 신규 균주 KME-002, 이의 유전체 및 성분은 콜린산 유도체의 대량생산, 및 멍게 질병 예방 및 치료에 유용하게 이용될 수 있다.
박테리아 균주 KME-002, 콜린산 유도체, 7-케토데옥시콜린산, 3-옥소데옥시콜린산, 멍제 질병.-
公开(公告)号：KR1020100087495A
公开(公告)日：2010-08-05
申请号：KR1020090006514
申请日：2009-01-28
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A novel bacteria strain Aeromicrobium halocynthiae KME-001 is provided to produce taurocholic acid amoun cholic acid derivatives and to cause disease of sea squirt. CONSTITUTION: A novel bacteria strain Aeromicrobium halocynthiae KME-001(deposit number KFCC11430P) contains 16S rDNA of sequence number 1. The novel strain is aerobic gram-positive nonsporeforming Bacillus. The strain produces taurocholic acid of chemical formula 1. A method for producing taurocholic acid comprises: a step of inoculating Aeromicrobium halocynthiae KME-001 KME-001 to liquid medium and culturing; a step of adding adsorbent resin and organic solvent or directly adding organic solvent to the culture medium; a step of performing column chromatography to obtain a fraction; a step of performing column chromatography from the fraction to obtain taurocholic acid of chemical formula 1; and a step of purifying tauroholic acid.
Abstract translation: 目的：提供一种新型细菌菌株，气溶胶氧氟尿嘧啶KME-001，用于生产牛磺胆酸氨基酸衍生物并引起海吐病。 构成：一种新型细菌菌株蓝藻毒素KME-001（保藏号KFCC11430P）含有序列1的16S rDNA。新菌株为需氧革兰氏阳性非成芽芽孢杆菌。 该菌株产生化学式1的牛磺胆酸。一种制造牛磺胆酸的方法，其特征在于，包括：向液体培养基中接种卤代氯氰尿苷KME-001 KME-001并培养的步骤; 添加吸附树脂和有机溶剂或直接向培养基中加入有机溶剂的步骤; 进行柱色谱以获得级分的步骤; 从级分进行柱色谱以获得化学式1的牛磺胆酸的步骤; 和纯化牛磺罗维酸的步骤。
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公开(公告)号：KR100540758B1
公开(公告)日：2006-01-10
申请号：KR1020030039199
申请日：2003-06-17
Applicant: 한국과학기술연구원
IPC: A61B1/00
Abstract: 본 발명은 캡슐형 로봇 시스템에 관한 것으로서, 보다 상세하게는 인체의 소화기에 삽입되는 캡슐형 로봇 시스템에 관한 것으로서, 인체의 내장을 진단 및/또는 치료하기 위한 캡슐형 로봇 시스템에 있어서, 치료 및/또는 진단 도구가 탑재되는 본체와; 상기 본체에 설치되어 인체의 외부에서의 자기장의 변화에 의하여 상기 본체의 이동을 제어하는 외력반응부를 포함하는 것을 특징으로 한다.
캡슐형, 자석, 내시경-
公开(公告)号：KR100393523B1
公开(公告)日：2003-08-06
申请号：KR1020000002382
申请日：2000-01-19
Applicant: 한국과학기술연구원
IPC: C07D501/16
CPC classification number: Y02P20/55
Abstract: PURPOSE: A pyrazolopyridine substituted cephalosporin compound is provided, which have the wide antimicrobial activity for gram positive and gram negative bacteria. And a producing method thereof is also provided. CONSTITUTION: The pyrazolopyridine substituted cephalosporin compound is represented by formula (1), in which R1 is hydrogen, C1 to C3 alkyl, C1 to C3 alkyl containing hydroxy, C1 to C3 alkyl containing amine; and R2 is hydrogen, amino, amino protected by amine protecting groups, carboxy or its inorganic salts, carbarmoyl, C1 to C3 alkyl substituted carbarmoyl, C1 to C3 alkyl containing hydroxy, and C1 to C3 alkyl esterified carboxy. The method for producing the pyrazolopyridine substituted cephalosporin compounds comprises the steps of: reacting the compounds of formula (2) and (3); and deprotecting R3 and R4, in which R3 is amine protecting groups, R4 is carboxylic acid protecting groups; and Y is halogen or acetoxy.
Abstract translation: 目的：提供吡唑并吡啶取代的头孢菌素化合物，其对革兰氏阳性和革兰氏阴性细菌具有广泛的抗微生物活性。 并且还提供了其制造方法。 组成：取代的头孢菌素化合物的吡唑并吡啶是由式（1）表示，其中R1是氢，C1-C3烷基，C1至C3烷基含羟基，C1至含胺C3烷基; 和R2是氢，氨基，被胺保护基团保护的氨基，羧基或其无机盐，氨基甲酰基，C1-C3烷基取代的氨基甲酰基，含有C1-C3烷基的羟基和C1-C3烷基酯化的羧基。 生产吡唑并吡啶取代的头孢菌素化合物的方法包括以下步骤：使式（2）和（3）的化合物反应; 并将R3和R4去保护，其中R3是胺保护基，R4是羧酸保护基; Y是卤素或乙酰氧基。
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