公开(公告)号：KR1020040105183A

公开(公告)日：2004-12-14

申请号：KR1020030036482

申请日：2003-06-05

Applicant: 한국과학기술연구원

Inventor： 이용섭 ,  진창배 ,  이재열 ,  김형자 ,  서선희 ,  송윤선

IPC: A61K31/70

CPC classification number: A61K36/744 ,  A23L33/105 ,  A61K8/97 ,  A61K2236/33 ,  A61K2800/522 ,  A61Q19/08

Abstract: PURPOSE: Provided are the Gardeniae fructus extract having free radical scavenging activity and antiviral activity, novel compounds isolated therefrom and the use thereof for prevention and treatment of viral diseases, such as AIDS. CONSTITUTION: The Gardeniae fructus extract is obtained by extracting Gardeniae fructus with water or organic solvents. It contains as an active ingredent, methyl-0-caffeoyl-4-0-sinapolylquinate, methyl 3,5-0-dicarffeoyl-4-0-(3-hydroxy-3-methyl)glutaroylquinate, ethyl 5-0-caffeoyl-4-0-sinapoylquinate, methyl -0-caffeoyl--0-sinapoylquinate, ethyl 3-0-caffeoyl-5-0-sinapoylquinate, 3,5-0-dicaffeoylquinic acid, and 4,5-0-dicaffeoylquinic acid.

Abstract translation: 目的：提供具有自由基清除活性和抗病毒活性的栀子提取物，从其中分离的新化合物及其用于预防和治疗病毒性疾病如AIDS的用途。 构成：栀子提取物通过用水或有机溶剂萃取栀子获得。 它含有作为活性成分的甲基O-咖啡酰基-4-0-辛酰基喹喔啉，3,5-0-二甲酰基-4-0-（3-羟基-3-甲基）戊酰基喹啉甲基，5-0-咖啡酰基 - 4-0-辛酰基喹喔啉，O-咖啡酰基-O-辛酰基喹喔啉，3-0-咖啡酰基-5-0-辛酰基喹喔啉，3,5-0-二苯甲酰奎宁酸，和4,5-0-二茄酸奎宁酸。

公开(公告)号：KR101663662B1

公开(公告)日：2016-10-14

申请号：KR1020150086032

申请日：2015-06-17

Applicant: 한국과학기술연구원

Inventor： 배애님 ,  서선희 ,  민선준 ,  조용서 ,  금교창 ,  박기덕 ,  성지혜 ,  조경희 ,  김태훈 ,  손우승

IPC: C07D413/04 ,  C07D261/06 ,  A61K31/42

Abstract: 본발명은대사성글루타메이트수용체 1에대한길항제로서활성을보이는아릴아이소옥사졸유도체, 이화합물의제조방법및 이화합물을활성성분으로포함하는약제조성물에관한것이다.

公开(公告)号：KR101446680B1

公开(公告)日：2014-10-07

申请号：KR1020130014392

申请日：2013-02-08

Applicant: 한국과학기술연구원

Inventor： 추현아 ,  민선준 ,  서선희 ,  김지연 ,  기유란 ,  김민주 ,  김소라 ,  김영재

IPC: C07D495/04 ,  A61K31/519 ,  A61P25/00

CPC classification number: C07D495/04 ,  A61K31/519

Abstract: 본 발명은 대사성 글루타메이트 수용체 서브타입 1에 길항제로 작용하여 대사성 글루타메이트 수용체 관련 질환, 즉 신경병성 통증과 편두통과 같은 통증, 불안장애나 정신분열증과 같은 정신질환, 요실금, 그리고 파킨스병이나 알츠하이머병과 같은 퇴행성 뇌질환 등에 약학적 활성을 보이는 사이에노피리미디논 유도체, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약제조성물에 관한 것이다.

公开(公告)号：KR101351338B1

公开(公告)日：2014-01-14

申请号：KR1020110043180

申请日：2011-05-06

Applicant: 한국과학기술연구원

Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  서선희 ,  송치만 ,  신선미 ,  아미드,압둘와히드

IPC: C07D403/12 ,  A61K31/496 ,  A61P25/00

Abstract: 본 발명은 칼슘 채널에 약학적 활성을 보이는 피라조일 피페라진 화합물 및 약제학적으로 허용 가능한 이의 염, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약제조성물에 관한 것이다.

公开(公告)号：KR101264903B1

公开(公告)日：2013-05-15

申请号：KR1020100117602

申请日：2010-11-24

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: 본발명은항균활성을갖는신규한옥사졸리디논유도체또는이의약학적으로허용가능한염, 이들의제조방법, 및상기옥사졸리디논유도체또는이의약학적으로허용가능한염을유효성분으로포함하는항균조성물에관한것으로서, 본발명의옥사졸리디논유도체또는이의약학적으로허용가능한염은다양한내성균주를포함하는그람양성균에대하여우수한항균활성을나타낸다.

公开(公告)号：KR1020120097288A

公开(公告)日：2012-09-03

申请号：KR1020110016788

申请日：2011-02-24

Applicant: 한국과학기술연구원

Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  임혜원 ,  최기현 ,  서선희 ,  송치만 ,  구수진

IPC: C07D403/12 ,  C07D403/14 ,  A61K31/551 ,  A61P25/00

Abstract: PURPOSE: A pharmaceutical composition containing 1,4-diazepane pyrazole compound and a pharmaceutically acceptable salt thereof is provided to be used as an agent for preventing or treating brain diseases, heart diseases, cancer, epilepsy, and pain. CONSTITUTION: A 1,4-diazepane pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating brain diseases such as epilepsy, depression, Parkinson's diseases, dementia, sleep disorders, or heart diseases such as hypertension, cardiac arrhythmia, or myocardial infarction, or pain contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of reacting pyrazolemethyl amine of chemical formula 2 with chloroacetyl chloride.

Abstract translation: 目的：提供含有1,4-二氮杂环庚烷吡唑化合物及其药学上可接受的盐的药物组合物，用作预防或治疗脑疾病，心脏病，癌症，癫痫和疼痛的药剂。 构成：1,4-二氮杂环庚烷吡唑化合物由化学式1表示。用于预防和治疗脑疾病如癫痫，抑郁症，帕金森病，痴呆，睡眠障碍或心脏病如高血压，心律失常， 或心肌梗塞，或疼痛含有化学式1的化合物作为活性成分。 制备化学式1的化合物的方法包括使化学式2的吡唑甲胺与氯乙酰氯反应的步骤。

公开(公告)号：KR1020120097287A

公开(公告)日：2012-09-03

申请号：KR1020110016787

申请日：2011-02-24

Applicant: 한국과학기술연구원

Inventor： 조용서 ,  민선준 ,  이재균 ,  배애님 ,  임혜원 ,  최기현 ,  서선희 ,  송치만 ,  최연희

IPC: C07D401/12 ,  A61K31/454 ,  A61P25/00

Abstract: PURPOSE: A pharmaceutical composition containing pyrazoyl piperidine compounds and pharmaceutically acceptable salt thereof is provided to prevent or treat brain diseases, heard diseases, cancer, and pain. CONSTITUTION: A pyrazoyl piperidine compound is denoted by chemical formula 1. A pharmaceutical composition for treating cerebral diseases, cardiac diseases, cancer, or pain contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound comprises: a step of reacting piperidine acetate of chemical formula 2 and pyrazole methyl amine of chemical formula 3 of a step of reacting piperidine compound of chemical formula 4 with an aldehyde compound of chemical formula 5 by reduction-amination. [Reference numerals] (AA) Reductive amination

Abstract translation: 目的：提供含有吡唑基哌啶化合物及其药学上可接受的盐的药物组合物，以预防或治疗脑疾病，听到疾病，癌症和疼痛。 构成：化学式1表示吡唑基哌啶化合物。用于治疗脑疾病，心脏病，癌症或疼痛的药物组合物含有化学式1的化合物作为活性成分。 制备该化合物的方法包括：使化学式2的哌啶乙酸酯与化学式3的吡唑甲胺与化学式4的哌啶化合物与化学式5的醛化合物的还原胺化反应的步骤。 （参考号）（AA）还原胺化

公开(公告)号：KR101152657B1

公开(公告)日：2012-06-05

申请号：KR1020100038514

申请日：2010-04-26

Applicant: 한국과학기술연구원

Inventor： 조용서 ,  민선준 ,  이재균 ,  최연희 ,  배애님 ,  추현아 ,  임혜원 ,  최기현 ,  서선희 ,  송치만

IPC: C07D241/04 ,  A61K31/495 ,  A61P25/08 ,  A61P9/12

CPC classification number: Y02P20/55

Abstract: 본발명은 T-형칼슘채널에대한활성을갖는다이페닐프로판노일화합물, 상기화합물의제조방법, 그리고상기화합물을유효성분으로포함하는약학조성물에관한것이다. 본발명의다이페닐프로판노일화합물또는약학적으로허용가능한이의염은 T-형칼슘채널에대한길항작용을가지므로간질, 고혈압등의뇌질환치료제, 협심증등의심장질환치료제, 만성통증, 신경성통증등의통증질환치료제, 또는항암제로유용하다.

公开(公告)号：KR1020120056078A

公开(公告)日：2012-06-01

申请号：KR1020100117602

申请日：2010-11-24

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: An antibacterial composition containing novel oxazolidinone derivative is provided to ensure antibacterial activity against gram positive bacteria. CONSTITUTION: A novel oxazolidinone derivative with antibacterial activity is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 or the salt thereof comprises: a step of reacting an amine group of a compound of chemical formula 2 with a compound of chemical formula 3 or 4; and a step of substituting a hydroxyl group of an oxazolidinone derivative or a pharmaceutically acceptable salt thereof with a halogen group or methoxy group. An antibacterial composition contains the oxazolidinone derivative of chemical formula 1 or a salt thereof as an active ingredient.

Abstract translation: 目的：提供含有新恶唑烷酮衍生物的抗菌组合物，以确保对革兰氏阳性菌的抗菌活性。 构成：具有抗菌活性的新型恶唑烷酮衍生物由化学式1表示。化学式1化合物或其盐的制备方法包括：使化学式2的化合物的胺基与 化学式3或4; 以及将恶唑烷酮衍生物或其药学上可接受的盐的羟基与卤素基或甲氧基取代的步骤。 抗菌组合物含有化学式1的恶唑烷酮衍生物或其盐作为活性成分。

公开(公告)号：KR1020110139988A

公开(公告)日：2011-12-30

申请号：KR1020100060138

申请日：2010-06-24

Applicant: 한국과학기술연구원

Inventor： 남길수 ,  배애님 ,  최경일 ,  추현아 ,  와니 ,  서선희

IPC: C07D471/04 ,  C07D403/02 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: PURPOSE: A novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one is provided to suppress cancer cells. CONSTITUTION: A 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of alkylating 3-amino compounds of chemical formula 2 with haloalkylcarbonyl piperazine of chemical formula 3 by alkylating.

Abstract translation: 目的：提供新颖的1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮以抑制癌细胞。 构成：1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物由化学式1表示。用于抗癌的药物组合物含有化合物 的化学式1或其药学上可接受的盐作为活性成分。 制备化学式1的化合物的方法包括通过烷基化将化学式2的3-氨基化合物与化学式3的卤代烷基羰基哌嗪烷基化的步骤。