公开(公告)号：NZ544712A

公开(公告)日：2009-09-25

申请号：NZ54471204

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Disclosed are compounds of formula (I) wherein: X is S; Z is C; R1 and R3 are as described in the specification; and R2 is hydrogen or alkyl. Compounds of the type disclosed are tyrosine kinase inhibitors useful in the treatment of cancer.

公开(公告)号：CA2620223A1

公开(公告)日：2007-03-08

申请号：CA2620223

申请日：2006-09-01

Applicant: ABBOTT LAB

Inventor： MORYTKO MICHAEL J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  HIRST GAVIN C ,  CALDERWOOD DAVID J ,  DIXON RICHARD W ,  BREINLINGER ERIC C

IPC: A01N43/50

Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

公开(公告)号：BRPI0412894A

公开(公告)日：2006-10-03

申请号：BRPI0412894

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: A61P35/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AU2004259765A1

公开(公告)日：2005-02-03

申请号：AU2004259765

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： HRNCIAR PETER ,  DAVIS HEATHER M ,  BURCHAT ANDREW F ,  WADA CAROL K ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  FREY ROBIN R ,  RAFFERTY PAUL ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  MUCKEY MELANIE A ,  DAVIDSEN STEVEN K ,  MICHAELIDES MICHAEL R ,  BETSCHMANN PATRICK

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.