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公开(公告)号：CA2767091A1
公开(公告)日：2011-01-20
申请号：CA2767091
申请日：2010-07-14
Applicant: ABBOTT LAB
Inventor： PENNING THOMAS D , GANDHI VIRAJ B , ZHU GUIDONG , TONG YUNSONG , WOODS KEITH W , LAI CHUNQIU , GONG JANE , FLORJANCIC ALAN S
IPC: C07D487/04 , A61P35/00
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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公开(公告)号：DK1181269T3
公开(公告)日：2004-07-05
申请号：DK00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W , STEINER BETH A
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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公开(公告)号：DK1200412T3
公开(公告)日：2004-03-22
申请号：DK00950584
申请日：2000-07-21
Applicant: ABBOTT LAB
Inventor： WANG LE , LI QUN , WOODS KEITH W , SHAM HING L
IPC: C07D233/64 , A61K31/4164 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/00
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公开(公告)号：AT254110T
公开(公告)日：2003-11-15
申请号：AT00950584
申请日：2000-07-21
Applicant: ABBOTT LAB
Inventor： WANG LE , LI QUN , SHAM HING L , WOODS KEITH W
IPC: C07D233/64 , A61K31/4164 , A61P35/00 , A61P43/00 , C07D233/54
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公开(公告)号：BR0007589A
公开(公告)日：2002-10-15
申请号：BR0007589
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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Patent Agency Ranking
公开(公告)号：PL344861A1
公开(公告)日：2001-11-19
申请号：PL34486198
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： HENKIN JACK , DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：CA2378942A1
公开(公告)日：2001-02-08
申请号：CA2378942
申请日：2000-07-21
Applicant: ABBOTT LAB
Inventor： SHAM HING L , LI QUN , WANG LE , WOODS KEITH W
IPC: C07D233/64 , A61K31/4164 , A61P35/00 , A61P43/00 , C07D233/54
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein R1 is selected from the group consisting of hydrogen, methy l, ethyl, propyl, and isolpropyl; and one of R2 or R3 is 3,4,5-trimethoyxphenyl , and the other is phenyl substituted with one, two, or three substitutents independently selected from the group consisting of alkoxy, halo, and -NR4R5 , wherein R4 and R5 are independently selected from the group consisting of hydrogen and alkyl, inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
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公开(公告)号：SK8662000A3
公开(公告)日：2001-01-18
申请号：SK8662000
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： HENKIN JACK , DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：AU5227999A
公开(公告)日：2000-02-21
申请号：AU5227999
申请日：1999-07-23
Applicant: ABBOTT LAB
Inventor： GWALTNEY STEPHEN L II , JAE HWAN-SOO , KALVIN DOUGLAS M , LIU GANG , SHAM HING L , LI QUN , CLAIBORNE AKIYO K , WANG LE , BARR KENNETH J , WOODS KEITH W
IPC: C07D263/10 , C07D263/14 , C07D413/04 , C07D471/04 , C07D473/04 , A61K31/421 , A61K31/422
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公开(公告)号：AU1818599A
公开(公告)日：1999-07-05
申请号：AU1818599
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： HENKIN JACK , DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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