公开(公告)号：GB2407698A

公开(公告)日：2005-05-04

申请号：GB0423955

申请日：2004-10-28

Applicant: AGILENT TECHNOLOGIES INC

Inventor： LI GANGGIANG ,  GOODLEY PAUL C ,  YIN HONGFENG

IPC: G01N27/62 ,  B05B5/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16

Abstract: Electrospray apparatus, includes: a nozzle providing an exit orifice (130), an entrance orifice, and a passage (126) extending from the entrance orifice to the exit orifice (130), the nozzle defining a nozzle axis (124); an interface providing an inlet (112), an outlet, and a passage extending from the inlet to the outlet, the interface providing an interface axis(122); the interface disposed such that the inlet (112) is adjacent the exit orifice (130) and the interface axis (122) is in transverse relation to the nozzle axis (124); wherein an angle formed between the nozzle axis (124) and the interface axis (122) is between about 75 degrees and about 105 degrees, the interface operable to receive a voltage from an interface voltage source; an auxiliary electrode (140) operable to receive a voltage from an auxiliary voltage source (132), and to modulate an electric field at the exit orifice (130), the electrospray apparatus being operable to define an ion pathway followed by ions enroute from the exit orifice to the inlet, the auxiliary electrode (140) being disposed outside the ion pathway. The auxiliary electrode (140) may be a disk electrode, a pin electrode or an L-shaped electrode. A lumen (110) may supply a counterflow of drying gas (136).

公开(公告)号：DE69721598T2

公开(公告)日：2004-04-08

申请号：DE69721598

申请日：1997-01-16

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  KEELY-TEMPLIN CATHERINE A ,  MCMANIGILL DOUGLASS ,  HOLLOWAY ROBERT R

IPC: G01N27/447

Abstract: A wide-bore capillary electrophoresis apparatus (200) for analysis of analyte ions is provided. The apparatus (200) has a wide-bore capillary (204) that has a restriction zone (106) at one or more ends (208, 216). The capillary has an inlet end (208) and an outlet end (216) and an opening (118) at each of said ends. The restriction zone (106) is capable of providing fluid communication between the wide bore (102) and the opening (118) at said end. The restriction zone (106) includes a narrow bore (114) extending to the opening and a transition zone (110) providing gradual change of bore diameter from the wide bore (102) to the narrow bore (114). The apparatus (200) further has a buffer source (212) to supply buffer to the inlet end (208) of the capillary (204) and a power supply (232) for supplying power to drive buffer and analyte ions through the capillary During CE, electrodes (224, 228) provide electrical communication between the power supply (232) and the inlet end (208) and the outlet end (216) to apply a voltage differential between said ends.

公开(公告)号：DE10227593A1

公开(公告)日：2003-02-06

申请号：DE10227593

申请日：2002-06-20

Applicant: AGILENT TECHNOLOGIES INC

Inventor： KILLEEN KEVIN ,  YIN HONGFENG

IPC: F15C5/00 ,  F16K99/00 ,  B81B3/00 ,  B81B7/00 ,  G01N30/00

Abstract: A microdevice is provided for controlling fluid flow. The microdevice includes a substantially planar contact surface and a plurality of fluid-transporting features associated therewith. Also included is a substrate having a substantially planar contact surface and a fluid-transporting feature associated therewith. The contact surfaces are positioned in slidable and fluid-tight contact to allow for controllable formation of a plurality of different flow paths upon alignment of the substrate fluid-transporting feature with each cover plate fluid-transporting features in succession. Typically, at least one of the cover plate and substrate is comprised of a biofouling resistant polymer, and the flow paths are of different lengths. Optionally, a plurality of fluid-transporting features is associated with the substrate so that flow paths are formed as a result of a different alignment of the fluid-transporting features.

公开(公告)号：DE10063998A1

公开(公告)日：2001-07-05

申请号：DE10063998

申请日：2000-12-21

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  TEMPLIN CATHERINE

IPC: G01F1/684 ,  G01F1/708 ,  G01F1/68 ,  G01F1/704

Abstract: The flow channel (10) has a heater inducing temperature perturbations, an interrogation unit (24) operating with a capacitative cell or an optical system including a detector taking measurements, a rate-determining instrument (18) connected to the detector which monitors a specific characteristic, e.g. resistance or refractive index, hence determining fluid flowrate. An Independent claim is included for the corresponding method of measurement.

公开(公告)号：GB2433449A

公开(公告)日：2007-06-27

申请号：GB0625308

申请日：2006-12-19

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  KILLENN KEVIN ,  BRENNEN REID

IPC: B01L99/00 ,  G01N30/16 ,  B01D15/14 ,  B81B1/00 ,  G01N30/60

Abstract: Fluidic separation devices (10) and methods with reduced sample broadening are provided. A column (25) is located downstream from a holding chamber (53), and a flow providing means provides fluid flow effective to convey a sample along a flow path that extends from the holding chamber (53) into the separation column (25). The sample is typically focused in the flow path upstream from the separation column (25). Optionally, the invention may be employed with electrospray mass spectrometry and in microfluidic applications. The means for focusing the sample may preferably be achieved by using material that makes holding chamber less sample retentive than the separation column, providing a heat source to the holding chamber and/or having an inlet conveying fluid downstream from the holding chamber and upstream from the separation column.

公开(公告)号：DE10154601B4

公开(公告)日：2007-02-22

申请号：DE10154601

申请日：2001-11-07

Applicant: AGILENT TECHNOLOGIES INC

Inventor： BRENNEN REID A ,  YIN HONGFENG ,  KILLEEN KEVIN P

IPC: B81C1/00 ,  B01D57/00 ,  B05B5/025 ,  B23K26/00 ,  B81B1/00 ,  C12M1/00 ,  G01N27/62 ,  H01J49/04

公开(公告)号：DE19929734B4

公开(公告)日：2005-10-06

申请号：DE19929734

申请日：1999-06-29

Applicant: AGILENT TECHNOLOGIES INC

Inventor： ROBOTTI KARLA M ,  SWEDBERG SALLY A ,  YIN HONGFENG

IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81B3/00 ,  F15C5/00 ,  F16K99/00 ,  B01L11/00

Abstract: Micro-fluid devices and methods for their use are provided. The subject devices are characterized by the presence of at least one micro-valve comprising a phase reversible material, e.g. a reversible gel, that reversibly changes its physical state in response to an applied stimulus, e.g. a thermoreversible gel. In using the subject device, fluid flow along a flow path of the device is modulated by applying an appropriate stimulus, e.g. changing the temperature, to the microvalve. The subject devices find use in a variety of applications, including micro-analytical applications.

公开(公告)号：DE102004045706A1

公开(公告)日：2005-06-16

申请号：DE102004045706

申请日：2004-09-21

Applicant: AGILENT TECHNOLOGIES INC

Inventor： LI GANGGIANG ,  GOODLEY PAUL C ,  YIN HONGFENG

IPC: G01N27/62 ,  B05B5/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16

Abstract: The invention provides an electrospray apparatus with an auxiliary electrode, and a method of using.

公开(公告)号：DE69721598D1

公开(公告)日：2003-06-12

申请号：DE69721598

申请日：1997-01-16

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  KEELY-TEMPLIN CATHERINE A ,  MCMANIGILL DOUGLASS ,  HOLLOWAY ROBERT R

IPC: G01N27/447

Abstract: A wide-bore capillary electrophoresis apparatus (200) for analysis of analyte ions is provided. The apparatus (200) has a wide-bore capillary (204) that has a restriction zone (106) at one or more ends (208, 216). The capillary has an inlet end (208) and an outlet end (216) and an opening (118) at each of said ends. The restriction zone (106) is capable of providing fluid communication between the wide bore (102) and the opening (118) at said end. The restriction zone (106) includes a narrow bore (114) extending to the opening and a transition zone (110) providing gradual change of bore diameter from the wide bore (102) to the narrow bore (114). The apparatus (200) further has a buffer source (212) to supply buffer to the inlet end (208) of the capillary (204) and a power supply (232) for supplying power to drive buffer and analyte ions through the capillary During CE, electrodes (224, 228) provide electrical communication between the power supply (232) and the inlet end (208) and the outlet end (216) to apply a voltage differential between said ends.

公开(公告)号：GB2379080A

公开(公告)日：2003-02-26

申请号：GB0207112

申请日：2002-03-26

Applicant: AGILENT TECHNOLOGIES INC

Inventor： YIN HONGFENG ,  DOHERTY THOMAS P ,  SWEDBURG SALLY A

IPC: H01J49/04

Abstract: A microfabricated device 30 for introducing a small volume of a fluid sample into the ionization chamber of an inductively coupled plasma mass spectrometer (ICP-MS) is constructed from a substrate 32 having first 34 and second 36 opposing surfaces. A microchannel 38 formed in the first surface 34 and a cover plate 50 arranged over the first surface 34 define a conduit for conveying the sample. A sample inlet port 54 in fluid communication with micro-channel 38 allows the fluid sample from an external source to be conveyed in a defined flow path through the conduit and a sample outlet port 56 into the ionisation chamber. Optionally, the sample undergoes a chemical or biochemical reaction within the microdevice before reaching the ionisation chamber. A nebulizing means 58 nebulises the fluid sample in a region adjacent to the outlet port.