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    New carbocyclic and heterocyclic carboxylic acid or tetrazolyl compounds
    24.
    发明专利
    New carbocyclic and heterocyclic carboxylic acid or tetrazolyl compounds 未知

    公开(公告)号：DE19652763A1

    公开(公告)日：1998-06-25

    申请号：DE19652763

    申请日：1996-12-18

    Applicant: BASF AG

    Inventor： AMBERG WILHELM DR ,  JANSEN ROLF DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  HERGENROEDER STEFAN DR ,  RASCHACK MANFRED DR ,  UNGER LILIANE DR

    IPC: C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D491/04 ,  A61K31/195 ,  A61K31/53 ,  C07D241/14 ,  C07D241/36 ,  C07D255/00 ,  C07D487/06 ,  C07D493/04 ,  C07D495/04

    Abstract: Heterocyclic compounds of formula (I) and their salts are new. R1 = tetrazolyl, or COR; R = OR6, O(CH2)pS(O)kR7, NHS(O)2R8 or a 5-membered azaheteroaryl; R2 = 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl (all optionally substituted), H, halo, 1-4C alkoxy, 1-4C haloalkoxy, 3-6C alkenyloxy, 3-6C alkynyloxy, 1-4C alkylthio, 1-4C alkylcarbonyl, 1-4C alkoxycarbonyl, NH(1-4C alkyl), N(1-4C alkyl)2, OH, carboxy or amino; R3, R4 = phenyl, naphthyl or 3-8C cycloalkyl (all optionally substituted); or R3+R4 = two of phenyl, naphthyl linked at the o-position by a bond, methylene, ethylene, ethenyl, S, SO2, NH or N-alkyl; R5 = H, 1-8C alkyl, 3-8C alkenyl, 3-8C alkynyl, Ph, naphthyl, 5-6 membered heteroaromatic (containing 1-3 N, S and/or O), or 3-8C cycloalkyl (all optionally substituted); R6 = H, alkali metal or earth-alkali metal, organic ammonium, 3-8C cycloalkyl, 1-8C alkyl, or (all optionally substituted) benzyl, 3-8C alkenyl, 3-8C alkynyl or phenyl; R7 = 1-4C alkyl, 3-8C cycloalkyl, 3-8C alkenyl, 3-8C alkynyl or optionally substituted phenyl; R8 = 1-4C alkyl, 3-8C alkenyl, 3-8C alkynyl, 3-8C cycloalkyl (all optionally substituted by 1-4C alkoxy, 1-4C alkylthio and/or phenyl), 1-4C haloalkyl or optionally substituted phenyl; X = N, Y = N or CR9 and Z = N; or X = CH, Y = N or CR9 and Z = N or CR10 provided that Y or Z = N; R9, R10 = 1-4C alkyl, 2-4C alkenyl or 2-4C alkynyl (all optionally substituted), H, OH, NH2, NH(1-4C alkyl), N(1-4C alkyl)2, halo, 1-4C alkoxy, 1-4C haloalkoxy or 1-4C alkylthio; or CR2+CR9 or CR2+CR10 completes a 5-6 membered alkylene or alkenyl ring (optionally substituted) with one or more CH2 optionally replaced by O, S, NH or N(1-4C alkyl); Q = N and W = bond; or Q = O and W = S, O or a bond; k = 0-2; and p = l-4.

    25.
    发明专利
    未知

    公开(公告)号：DE19636046A1

    公开(公告)日：1998-03-12

    申请号：DE19636046

    申请日：1996-09-05

    Applicant: BASF AG

    Inventor： AMBERG WILHELM DR ,  JANSEN ROLF DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  HERGENROEDER STEFAN DR ,  RASCHACK MANFRED DR ,  UNGER LILIANE DR

    IPC: A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61P9/04 ,  A61P9/08 ,  A61P9/12 ,  A61P43/00 ,  C07C59/66 ,  C07C69/734 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D491/04 ,  C07D491/048 ,  C07D405/10 ,  C07D403/12 ,  C07D251/12 ,  C07C59/64 ,  A61K31/41

    Abstract: Carboxylic acid derivatives have the formula (I), in which R stands for tetrazole or a group (a); R stands for hydrogen, hydroxy, NH2, NH(C1-c4-alkyl), N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkinyl, C1-C4-alkyl halide, C1-C4-alkoxy, C1-C4-alkoxy halide or C1-C4-alkylthio, or CR is linked with CR , as indicated below, into a 5- or 6-membered ring; X stands for nitrogen or methine; Y stands for nitrogen or methine; Z stands for nitrogen or CR , wherein R is hydrogen or C1-C4-alkyl or CR forms together with CR or CR an optionally substituted 5- or 6-membered alkylene or alkenylene ring, and wherein one or more methylene groups can be substituted by hydrogen, sulphur, -NH or -N(C1-C4-alkyl); R stands for hydrogen, hydroxy, NH2, NH(C1-C4-alkyl), N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkinyl, C1-C4-hydroxyalkyl, C1-C4-alkyl halide, C1-C4-alkoxy, C1-C4-alkoxy halide, C1-C4-alkylthio; or CR is linked to CR as indicated above into a 5- or 6-membered ring, R and R (which may be identical or different) stand for optionally substituted phenyl or naphthyl, or for phenyl or naphthyl which are linked to each other at the ortho-position by a direct bond, a methylene, ethylene or ethenylene group, an oxygen or sulphur atom or an SO2, NH or N-alkyl group; optionally substituted C3-C8-cycloalkyl; R stands for optionally substituted C3-C8-cycloalkyl; optionally substituted phenyl or naphthyl, a 5- or 6-membered, optionally substituted heteroaromatic compound containing one to three nitrogen atoms and/or one sulphur or oxygen atom; W stands for sulphur or oxygen; Q is a spacer with a length that corresponds to a C2-C4 chain. Also disclosed are the physiologically tolerable salts of these compounds, as well as their pure enantiomer and diastereoisomer forms, their preparation and use as mixed ETA/ETB-receptor antagonists.

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