公开(公告)号：DE4411225A1

公开(公告)日：1995-10-05

申请号：DE4411225

申请日：1994-03-31

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention concerns the use of carboxylic acid derivatives of formula I (I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR , wherein R means hydrogen or, together with R , forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituents have the meanings given in the description. These derivatives can be used for preparing medicaments.

公开(公告)号：DE4408891A1

公开(公告)日：1995-09-21

申请号：DE4408891

申请日：1994-03-16

Applicant: BASF AG

Inventor： KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  ENDLER-JOBST ANNI BARBARA DR

IPC: C12N15/09 ,  C07K14/705 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/66 ,  C12Q1/68 ,  C12Q1/6897 ,  C12Q1/56

公开(公告)号：DE4400746A1

公开(公告)日：1995-07-20

申请号：DE4400746

申请日：1994-01-13

Applicant: BASF AG

Inventor： SEULBERGER HARALD DR ,  BIALOJAN SIEGFRIED DR

IPC: C12Q1/68 ,  C12Q1/6897 ,  C12Q1/66

Abstract: Substances (I) that influence expression of angiotensinogen (II) are identified by (1) transfecting a host cell with a recombinant vector that contains the regulatory region of the (II) gene functionally coupled to a reporter gene (RG); (2) either (a) isolating cells that carry the vector transiently or (b) generating cell lines that have stably integrated the vector, (3) exposing these cells to test cpds. and (4) measuring expression of RG.

公开(公告)号：DE4209110A1

公开(公告)日：1993-05-27

申请号：DE4209110

申请日：1992-03-20

Applicant: BASF AG

Inventor： STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR ,  KROEGER BURKHARD DR ,  FRIEDRICH THOMAS DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

Abstract: Described are new thrombin-inhibiting proteins obtained from terrestrial leeches of the species Haemadipsa and with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Th r-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly- Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-As p-Glu-Glu-Glu-Lys or an amino-acid sequence obtained by C-terminal shortening the above sequence by one to twelve amino acids. The proteins are suitable for use against illnesses. Also described are the nucleic acids coding for these proteins.

公开(公告)号：DE4031731A1

公开(公告)日：1992-04-09

申请号：DE4031731

申请日：1990-10-06

Applicant: BASF AG

Inventor： STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K38/00 ,  A61P7/02 ,  C07K14/435 ,  C07K14/815

Abstract: Described is a new protein, suitable for use in the treatment of illnesses, produced from Hirudo medicinalis. The protein extends the clotting time of blood, is relatively stable to heat and has a molecular weight of 25-34 KDa. Also described are the muteins of the new protein.

公开(公告)号：DE4023699A1

公开(公告)日：1992-01-30

申请号：DE4023699

申请日：1990-07-26

Applicant: BASF AG

Inventor： BACH ALFRED DR ,  HILLEN HEINZ DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57

Abstract: Described are glycosylated, partially glycosylated or unglycosylated polypeptides with the amino-acid sequence given in the sequence protocol and in which up to 10 amino acid groups can be replaced by other, naturally occurring, amino acids. The peptides are suitable for use in treating illnesses.

公开(公告)号：DE3936594A1

公开(公告)日：1991-03-28

申请号：DE3936594

申请日：1989-11-03

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED DR ,  FRIEDRICH THOMAS DR ,  MEYER THOMAS DR ,  STRUBE KARL-HERMANN DR

IPC: A61K31/715 ,  A61K38/45 ,  A61K38/46 ,  A61K38/54 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  C12N9/10

Abstract: The description relates to the use of gamma glutamyl transferases in the treatment of diseases.

公开(公告)号：DE3823805A1

公开(公告)日：1990-01-18

申请号：DE3823805

申请日：1988-07-14

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  SCHWARZ MARGARETE DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: C12N9/64 ,  A61K38/46 ,  A61P7/02 ,  C12N9/72 ,  C12N15/57 ,  C12N15/58