公开(公告)号：CA2500793A1

公开(公告)日：2004-04-15

申请号：CA2500793

申请日：2003-10-01

Applicant: BASF AG

Inventor： WULFF CHRISTIAN ,  NOERENBERG RALF ,  KLUGE MICHAEL ,  WAGNER NORBERT

IPC: A61K8/39 ,  A61Q19/10 ,  C07C43/13 ,  C07D303/22 ,  C07D317/36 ,  C11D1/72 ,  C11D17/00 ,  C07C43/10 ,  C07C41/03 ,  C07C43/12 ,  C11D3/20

Abstract: The invention relates to reaction products of 2-propylheptanol with 1-haloge n- 2,3-epoxypropanes and 1-hydroxy-2,3-epoxypropane (glycidol), to methods for the production thereof, and to the use of the same as co-surfactants, cleani ng surfactants or thickening agents.

公开(公告)号：DE50004382D1

公开(公告)日：2003-12-18

申请号：DE50004382

申请日：2000-02-10

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER

IPC: C07C277/02 ,  C07C277/08 ,  C07C279/14

公开(公告)号：AT249426T

公开(公告)日：2003-09-15

申请号：AT99125660

申请日：1999-12-22

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  GREINDL THOMAS ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER ,  RAULS MATTHIAS ,  VAN GELDER RICHARD

IPC: C07C277/08 ,  C07C279/14 ,  C07C303/22 ,  C07C309/15 ,  C07F9/38

Abstract: Preparation of guanidine derivatives (I) comprises reacting O-alkylisourea salts (II) with an amine (III) in the presence of seed crystals of (I). Preparation of guanidine derivatives of formula (I) comprises reacting O-alkylisourea salts of formula (II) with an amine of formula (III) in the presence of seed crystals of (I). R1 = 1-8C alkylene or a divalent 5-10C cycloaliphatic group; R2 = H or 1-8C alkyl; or NR1R2 = 5-6 membered ring substituted by Z; Z = COOR3, SO2OR3 or PO(OR3)(OR4); R3 = H, alkalimetal or an equivalent of an alkaline earth metal; and R4 = as for R3 or 1-6C alkyl; R5 = 1-8C alkyl; X = equivalent of an anion.

公开(公告)号：DE10105030A1

公开(公告)日：2002-08-08

申请号：DE10105030

申请日：2001-02-05

Applicant: BASF AG

Inventor： KLUGE MICHAEL ,  HILDEBRANDT SOEREN ,  WAGNER NORBERT ,  WEHLAGE THOMAS

IPC: C07D223/10 ,  C07D227/087

Abstract: The invention relates to a method for producing N,N'-carbonylbis- epsilon -caprolactam by the single-stage reaction of epsilon -caprolactam with phosgene, optionally in an inert organic solvent, in the presence of an organic nitrogenous base without an acylable nitrogen atom. The invention is characterised in that the organic nitrogenous base has a pKa-value of between 5 and 7. N,N-dimethylaniline is the preferred nitrogenous base.

公开(公告)号：DE10105029A1

公开(公告)日：2002-08-08

申请号：DE10105029

申请日：2001-02-05

Applicant: BASF AG

Inventor： KLUGE MICHAEL ,  HILDEBRANDT SOEREN ,  WAGNER NORBERT ,  WEHLAGE THOMAS

IPC: C07D201/02 ,  C07D201/16 ,  C07D223/10 ,  C07D227/087 ,  C08G69/14

Abstract: The invention relates to a method for producing N,N'carbonylbis- epsilon -caprolactam by reacting epsilon -caprolactam with phosgene in the presence of a hydrogen chloride-binding agent in an inert organic solvent and isolating the reaction product from the product solution. The isolation comprises the following steps: a) optionally distilling off a part of the organic solvent from the product solution; b) adding water to the product solution; c) removing the organic solvent by azeotropic distillation, optionally while replacing the water distilled off, thereby deploying the product solution of organic solvent; d) allowing the N,N'-carbonylbis- epsilon -caprolactam to crystallize from the solution that is deployed from organic solvent, thereby obtaining an aqueous suspension of N,N'-carbonylbis- epsilon -caprolactam; and e) removing the crystallized product.

公开(公告)号：CA2406651A1

公开(公告)日：2001-11-15

申请号：CA2406651

申请日：2001-05-09

Applicant: BASF AG

Inventor： BOECKH DIETER ,  KLUGE MICHAEL ,  NORENBERG RALF ,  HILDEBRANDT SOREN

IPC: C08L101/02 ,  C08F8/44 ,  C11D3/37 ,  H01B1/06 ,  H01B13/00

Abstract: The invention relates to polyelectrolyte complexes of cationic and anionic polymers, comprising (a) cationic condensates of (i) at least one amine and (ii) a cross-linking agent from the group of epihalohydrins, or bishalohydri ns of diols, bishalohydrins of polyalkylene glycols, bishalohydrins of polytetrahydrofurans, alkylene dihalides, alkylene trihalides, bis-epoxides, tris-epoxides, tetra-epoxides, and/or mixtures of the above and/or quaternar y cationic condensates of (i) and (ii) and (b) anionic compounds with at last three anionic groups and a loading ratio of anionic to cationic polymers of 0.01 to 20. The invention further relates to methods for the production of t he polyelctrolyte complexes by means of mixing the cationic condensates (a) wit h anionic compounds (b).

公开(公告)号：DE19920962A1

公开(公告)日：2000-11-16

申请号：DE19920962

申请日：1999-05-06

Applicant: BASF AG

Inventor： PUETTER HERMANN ,  FISCHER ANDREAS ,  GREINDL THOMAS ,  KESSEL KNUT ,  KLUGE MICHAEL

IPC: B01D61/44 ,  C07C227/40 ,  C07C229/12 ,  B01D61/42 ,  C07C277/08 ,  C07C279/14

Abstract: Production of a sarcosine solution with a predetermined pH comprises subjecting a crude sarcosine solution to bipolar electrodialysis. Independent claims are also included for the following: (1) an integrated process for producing a sarcosine solution with a predetermined pH, comprising: (i) producing a crude sarcosine solution; and (ii) subjecting the solution to bipolar electrodialysis; (2) an integrated process for producing creatine or creatine monohydrate, comprising performing steps (i) and (ii) as in process (1) and reacting the solution from step (ii) with cyanamide.

公开(公告)号：DE19905711A1

公开(公告)日：2000-08-17

申请号：DE19905711

申请日：1999-02-11

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER

IPC: C07C277/02 ,  C07C277/08 ,  C07C279/14 ,  C07B43/00 ,  C07C277/06 ,  C07C309/15 ,  C07D207/10 ,  C07D211/36 ,  C07F9/40

公开(公告)号：DE19841525A1

公开(公告)日：2000-03-16

申请号：DE19841525

申请日：1998-09-10

Applicant: BASF AG

Inventor： KESSEL KNUT ,  SCHERR GUENTER ,  KLUGE MICHAEL ,  BIEDERMANN NORBERT ,  GREINDL THOMAS ,  BOGENSTAETTER THOMAS ,  HAEHNLEIN WOLFGANG

IPC: C07C279/14 ,  C07C277/02 ,  C07C277/08

Abstract: Preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at 20-150 degrees C and pH 7.0 to 14.0, the pH value is obtained using carbonic acid.

公开(公告)号：AT141616T

公开(公告)日：1996-09-15

申请号：AT92911774

申请日：1992-06-17

Applicant: BASF AG

Inventor： EMLING FRANZ ,  HAUPT ANDREAS ,  KLUGE MICHAEL ,  KRONER MATTHIAS ,  HAAS GERHARD ,  SCHMIDT ULRICH ,  GRIESSER HELMUT ,  RIEDL BERND

IPC: A61K38/00 ,  A61K38/12 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07K5/08 ,  C07K11/02

Abstract: PCT No. PCT/EP92/01304 Sec. 371 Date Dec. 16, 1993 Sec. 102(e) Date Dec. 16, 1993 PCT Filed Jun. 17, 1992 PCT Pub. No. WO93/00362 PCT Pub. Date Jan. 7, 1993.Antitumor peptides of the formula I where R1, R2, R3, R4 and R5 have the meanings stated in the description, and the preparation thereof.