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    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    22.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG10202107927VA

    公开(公告)日：2021-08-30

    申请号：SG10202107927V

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    23.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG187392A1

    公开(公告)日：2013-02-28

    申请号：SG2012094876

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one o f the ports, fluid pressure is changed therein.FIG. 14B

    SINGLE-CELL NUCLEIC ACID ANALYSIS
    25.
    发明专利
    SINGLE-CELL NUCLEIC ACID ANALYSIS 未知

    公开(公告)号：SG183029A1

    公开(公告)日：2012-08-30

    申请号：SG2012052031

    申请日：2010-01-13

    Applicant: FLUIDIGM CORP

    Inventor： HAMILTON AMY ,  LIN MIN ,  MIR ALAIN ,  PIEPRZYK MARTIN

    Abstract: SINGLE-CELL NUCLEIC ACID ANALYSISThe present invention provides methods for analysis of genomic DNA and/or RNA from small samples or even single cells. Methods for analyzing genomic DNA can entail whole genome amplification (WGA), followed by preamplification and amplification of selected target nucleic acids. Methods for analyzing RNA can entail reverse transcription of the desired RNA, followed by preamplification and amplification of selected target nucleic acids.Fig. 1

    SINGLE-CELL NUCLEIC ACID ANALYSIS
    26.
    发明专利
    SINGLE-CELL NUCLEIC ACID ANALYSIS 未知

    公开(公告)号：SG172965A1

    公开(公告)日：2011-08-29

    申请号：SG2011050739

    申请日：2010-01-13

    Applicant: FLUIDIGM CORP

    Inventor： HAMILTON AMY ,  LIN MIN ,  MIR ALAIN ,  PIEPRZYK MARTIN

    Abstract: The present invention provides methods for analysis of genomic DNA and/or RNA from small samples or even single cells. Methods for analyzing genomic DNA can entail whole genome amplification (WGA), followed by preamplification and amplification of selected target nucleic acids. Methods for analyzing RNA can entail reverse transcription of the desired RNA, followed by preamplification and amplification of selected target nucleic acids.

    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    27.
    发明专利
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 未知

    公开(公告)号：SG169918A1

    公开(公告)日：2011-04-29

    申请号：SG2009066242

    申请日：2009-10-02

    Applicant: FLUIDIGM CORP

    Inventor： COHEN DAVID ,  MAY ANDREW ,  PIEPRZYK MARTIN ,  FOWLER BRIAN ,  LEE KIM HUAT ,  YAN JUN ,  ZHOU MING FANG ,  NG SENG BENG

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader. Fig. 1B

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