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    21.
    发明专利
    未知

    公开(公告)号：FR2900741B1

    公开(公告)日：2008-07-18

    申请号：FR0604019

    申请日：2006-05-05

    Applicant: MAUNA KEA TECHNOLOGIES SOC PAR

    Inventor： GENET MAGALIE ,  MATHIEU GILLES ,  VIELLEROBE BERTRAND ,  DOUSSOUX FRANCOIS ,  BOULAROT NICOLAS ,  LAVILLONNIERE NICOLAS

    IPC: G02B23/24 ,  A61B1/00

    Abstract: A miniaturized optical head provided to equip the distal end of a beam of flexible optical fibers scanned by a laser beam, is designed to come in contact with a sample and to excite the sample confocally. This optical head includes elements for correcting spherical aberrations and focusing members. The focusing members include: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and elements for correcting the axial and lateral chromatic aberration provided with a single divergent lens (3b) whose curvature is substantially centered on the pupil of the optical fiber beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).

    22.
    发明专利
    未知

    公开(公告)号：FR2871358B1

    公开(公告)日：2007-02-09

    申请号：FR0406396

    申请日：2004-06-14

    Applicant: MAUNA KEA TECHNOLOGIES SOC PAR

    Inventor： VIELLEROBE BERTRAND ,  JEAN FLORENCE ,  BOURG HECKLY GENEVIEVE ,  LOISEAU ALEXANDRE

    IPC: A61B5/00 ,  G01N21/64 ,  G02B21/00 ,  G02B23/26

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    23.
    发明专利
    未知

    公开(公告)号：DE60205408T2

    公开(公告)日：2006-06-01

    申请号：DE60205408

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

    IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

    Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

    25.
    发明专利
    未知

    公开(公告)号：AT320614T

    公开(公告)日：2006-04-15

    申请号：AT02801158

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Multimarking fiber fluorescence microscopic imagery system and method
    26.
    发明专利
    Multimarking fiber fluorescence microscopic imagery system and method 未知

    公开(公告)号：AU2005256758A1

    公开(公告)日：2006-01-05

    申请号：AU2005256758

    申请日：2005-06-09

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BOURG-HECKLY GENEVIEVE ,  VIELLEROBE BERTRAND ,  JEAN FLORENCE ,  LOISEAU ALEXANDRE

    IPC: G01N21/64 ,  A61B5/00 ,  G02B21/00 ,  G02B23/26

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    METHOD AND EQUIPMENT FOR FIBER OPTIC HIGH-RESOLUTION, IN PARTICULAR CONFOCAL, FLUORESCENCE IMAGING
    28.
    发明专利
    METHOD AND EQUIPMENT FOR FIBER OPTIC HIGH-RESOLUTION, IN PARTICULAR CONFOCAL, FLUORESCENCE IMAGING 未知

    公开(公告)号：AU2003273437A1

    公开(公告)日：2004-02-09

    申请号：AU2003273437

    申请日：2003-07-11

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： CLADE SOPHIE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

    Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

    29.
    发明专利
    未知

    公开(公告)号：FR2834349A1

    公开(公告)日：2003-07-04

    申请号：FR0116980

    申请日：2001-12-28

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

    IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

    Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

    30.
    发明专利
    未知

    公开(公告)号：FR2834348A1

    公开(公告)日：2003-07-04

    申请号：FR0116979

    申请日：2001-12-28

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

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