公开(公告)号：AU2006239018A1

公开(公告)日：2006-11-02

申请号：AU2006239018

申请日：2006-04-25

Applicant: UCB PHARMA SA

Inventor： KULISA CLAIRE LOUISE ,  ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP ,  CREPY KAREN VIVIANE LUCILE ,  BATCHELOR MARK JAMES ,  TURNER JAMES PETRIE ,  BROOKINGS DANIEL CHRISTOPHER ,  BUCKLEY GEORGE MARTIN

IPC: A61K31/4188 ,  A61K31/4184 ,  A61K31/55 ,  C07D277/82 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  C07D519/00

Abstract: A series of 5,6-dihydro-1,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：AU2004285752A1

公开(公告)日：2005-05-12

申请号：AU2004285752

申请日：2004-10-22

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  TREVITT GRAHAM PETER ,  ALEXANDER RIKKI PETER ,  LAING VICTORIA ELIZABETH ,  DAVIS JEREMY MARTIN

IPC: C07D495/04

Abstract: A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 3-position by an arylcarbonyl or heteroaryl-carbonyl moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

公开(公告)号：SI2170906T1

公开(公告)日：2013-07-31

申请号：SI200830975

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/00 ,  A61K31/00 ,  C07D519/00

公开(公告)号：HRP20130523T1

公开(公告)日：2013-07-31

申请号：HRP20130523

申请日：2013-06-12

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

公开(公告)号：ES2416364T3

公开(公告)日：2013-07-31

申请号：ES08775774

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: Compuesto de fórmula (I), un solvato o una sal farmacéuticamente aceptable del mismo: en la que: R11 representa hidrógeno o alquilo C1-6; R12 representa alquilo C1-6; T representa oxígeno o N-R25; V representa carbono; W representa carbono; R23 representa hidrógeno, halógeno, ciano, nitro, alquilo C1-6, hidroxi-alquilo C1-6, trifluorometilo, aril-alquilo C1-6,oxazolinilo, triazolilo, hidroxilo, alcoxilo C1-6, difluorometoxilo, trifluorometoxilo, cicloalcoxilo C3-7, cicloalquil C3-7-alcoxilo C1-6, morfolinil-alcoxilo C1-6, ariloxilo, aril-alcoxilo C1-6, alquiltio C1-6, alquilsulfinilo C1-6, arilsulfinilo,arilsulfonilo, alquilsulfoniloxilo C1-6, amino, azetidinilo, morfolinilo, alquilcarbonilamino C2-6, alquilcarbonilaminometiloC2-6, alcoxicarbonilamino C2-6, [alcoxicarbonil C2-6][alquil C1-6]amino, alquilsulfonilamino C1-6, alquilcarbonilo C2-6,alquilcarbonil C2-6-oxima, alquilcarbonil C2-6-O-(metil)oxima, trifluorometilcarbonilo, carboxilo, alcoxicarbonilo C2-6,aminocarbonilo, alquilaminocarbonilo C1-6, [hidroxi-alquil C1-6]aminocarbonilo, [di-alquil C1-6-amino-alquil C1-6]aminocarbonilo, di-alquil C1-6-aminocarbonilo, [alquil C1-6][ciano-alquil C1-6]aminocarbonilo, [alquil C1-6][hidroxi-alquilC1-6]aminocarbonilo, [alcoxi C1-6-alquil C1-6][alquil C1-6]aminocarbonilo, [di-alquil C1-6-amino-alquil C1-6][alquil C1-6]aminocarbonilo, cicloalquil C3-7-alquil C1-6-aminocarbonilo, aril-alquil C1-6-aminocarbonilo, heteroarilaminocarbonilo,heteroaril-alquil C1-6-aminocarbonilo, azetidinilcarbonilo, hidroxiazetidinilcarbonilo, aminoazetidinilcarbonilo,alcoxicarbonilaminoazetidinilcarbonilo C2-6, pirrolidinilcarbonilo, alquil C1-6-pirrolidinilcarbonilo, alcoxi C1-6-alquil C1-6-pirrolidinilcarbonilo, di-alquil C1-6-aminopirrolidinilcarbonilo, tiazolidinilcarbonilo, oxotiazolidinilcarbonilo,piperidinilcarbonilo, alquil C1-6-piperazinilcarbonilo, morfolinilcarbonilo, alquilsulfonilo C1-6, alquilsulfonil C1-6-metilo odi-alquil C1-6-aminosulfonilo.

公开(公告)号：DK2170906T3

公开(公告)日：2013-06-24

申请号：DK08775774

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

公开(公告)号：AT526021T

公开(公告)日：2011-10-15

申请号：AT06726894

申请日：2006-04-25

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP ,  BATCHELOR MARK JAMES ,  BROOKINGS DANIEL CHRISTOPHER ,  BUCKLEY GEORGE MARTIN ,  CREPY KAREN VIVIANE LUCILE ,  KULISA CLAIRE LOUISE ,  TURNER JAMES PETRIE

IPC: A61K31/4188 ,  A61K31/4184 ,  A61K31/55 ,  C07D277/82 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  C07D519/00

Abstract: A series of 5,6-dihydro-1,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：ZA200908997B

公开(公告)日：2011-02-23

申请号：ZA200908997

申请日：2009-12-17

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  FOLEY ANNE MARIE ,  CREPY KAREN VIVIANE LUCILE ,  AUJLA PAVANDEEP SINGH ,  ALEXANDER RIKKI PETER

公开(公告)号：DOP2009000289A

公开(公告)日：2010-03-31

申请号：DO2009000289

申请日：2009-12-22

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  C07D513/12 ,  C07D519/00

Abstract: Una serie de derivados de 6,7-dihidro[1,3]tiazolo[5,4-c]piridin-4(5H)-ona, que se sustituyen en la posicion 2 por un resto morfolin-4-ilo sustituido, que son inhibidores selectivos de enzimas P13 quinasa, y son, por lo tanto beneficiosos en medicina, por ejemplo en el tratamiento de afecciones inflamatorias, autoinmunes, cardiovasculares, neurodegenerativas, metabolicas, oncologicas, nociceptivas u oftalmologicas.

公开(公告)号：AT375330T

公开(公告)日：2007-10-15

申请号：AT01921580

申请日：2001-04-12

Applicant: UCB PHARMA SA

Inventor： NORMAN TIMOTHY ,  PORTER JOHN ,  HUTCHINSON BRIAN WOODSIDE ,  RATCLIFFE ANDREW JAMES ,  HEAD JOHN ,  ALEXANDER RIKKI PETER ,  LANGHAM BARRY ,  WARRELLOW GRAHAM ,  ARCHIBALD SARAH CATHERINE ,  LINSLEY JANEEN

IPC: C07D213/81 ,  A61K31/198 ,  A61K31/223 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4436 ,  A61K31/4545 ,  A61K31/472 ,  A61P1/04 ,  A61P3/10 ,  A61P11/06 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07C225/20 ,  C07C229/36 ,  C07D217/22 ,  C07D409/12 ,  C07D471/04

Abstract: Enamine derivatives of formula (1) are described:whereinR is a group Ar L Ar Alk- in, which Ar is an aromatic or heteroaromatic group, L is a covalent bond or a linker atom or group, Ar is an arylene or heteroarylene group and Alk is a chain -CH2-CH(R)-, -CH=C(R)- orin which R is a carboxylic acid or a derivative or biostere thereof;R is a hydrogen atom or a C1-6alkyl group;Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(R ) group;R is a oxo, thioxo, or imino group;R and R is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.