公开(公告)号：AU2012205127A1

公开(公告)日：2012-08-02

申请号：AU2012205127

申请日：2012-07-13

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO G ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  WANG JIAN ,  PIERCE ALBERT C ,  DUFFY JOHN P ,  MESSERSMITH DAVID

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P37/08 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

Abstract: The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2822057A1

公开(公告)日：2012-06-21

申请号：CA2822057

申请日：2011-12-16

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DAVIES IOANA ,  DUFFY JOHN P ,  GAO HUAI ,  FENG JUN ,  LIANG JIANGLIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE

IPC: C07D471/04 ,  A61K31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：AU2010262905A1

公开(公告)日：2012-01-12

申请号：AU2010262905

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： PAUL CHARIFSON ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  HONGBO DENG ,  IOANA DRUTU ,  DUFFY JOHN P ,  LUC FARMER ,  HUAI GAO ,  WENXIN GU ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  BRIAN LEDFORD ,  FRANCOIS MALTAIS ,  EMANUELE PEROLA ,  TIANSHENG WANG ,  WOODS WANNAMAKER M ,  RANDAL BYRN ,  YI ZHOU ,  CHAO LIN ,  MIN JIANG ,  STEVEN JONES ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：DK1791830T3

公开(公告)日：2011-04-18

申请号：DK05799808

申请日：2005-09-19

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO G ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  WANG JIAN ,  DUFFY JOHN P ,  MESSERSMITH DAVID ,  PIERCE ALBERT C

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P37/08 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

公开(公告)号：DE602005025655D1

公开(公告)日：2011-02-10

申请号：DE602005025655

申请日：2005-09-19

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO G ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  WANG JIAN ,  PIERCE ALBERT C ,  DUFFY JOHN P ,  MESSERSMITH DAVID

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P37/08 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

公开(公告)号：DE602006004844D1

公开(公告)日：2009-03-05

申请号：DE602006004844

申请日：2006-02-02

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK W ,  PIERCE ALBERT C ,  BEMIS GUY W ,  FARMER LUC J ,  WANG TIANSHENG ,  MESSERSMITH DAVID ,  DUFFY JOHN P ,  WANG JIAN ,  SALITURO FRANCESCO G

IPC: C07D487/04 ,  A61K31/519 ,  A61P7/00 ,  A61P11/00 ,  A61P19/00 ,  A61P37/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：NO20071915L

公开(公告)日：2007-05-18

申请号：NO20071915

申请日：2007-04-16

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO GERALD ,  WANG JIAN ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  PIERCE ALBERT C ,  DUFFY JOHN P ,  MESSERSMITH DAVID

IPC: C07D401/04 ,  A61K31/4196 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04

Abstract: The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.

公开(公告)号：NO20071915A

公开(公告)日：2007-05-18

申请号：NO20071915

申请日：2007-04-16

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO GERALD ,  WANG JIAN ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  PIERCE ALBERT C ,  DUFFY JOHN P ,  MESSERSMITH DAVID

IPC: C07D401/04 ,  A61K31/4196 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04

CPC classification number: C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

公开(公告)号：AU2006221065A1

公开(公告)日：2006-09-14

申请号：AU2006221065

申请日：2006-02-02

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK W ,  WANG JIAN ,  DUFFY JOHN P ,  FARMER LUC J ,  PIERCE ALBERT C ,  WANG TIANSHENG ,  SALITURO FRANCESCO G ,  BEMIS GUY W ,  MESSERSMITH DAVID

IPC: C07D487/04 ,  A61K31/519 ,  A61P7/00 ,  A61P11/00 ,  A61P19/00 ,  A61P37/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CZ292633B6

公开(公告)日：2003-11-12

申请号：CZ190598

申请日：1996-12-20

Applicant: VERTEX PHARMA

Inventor： BEMIS GUY W ,  DUFFY JOHN P ,  FRIDMAN WOLF HERMAN ,  GOLEC JULIAN M C ,  LIVINGSTON DAVID J ,  MULLICAN MICHAEL D ,  MURCKO MARK A ,  ZELLE ROBERT E

IPC: A61K38/00 ,  A61K38/55 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/06 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P43/00 ,  C07K5/00 ,  C07K5/02 ,  C07K5/08 ,  C07K5/083

Abstract: The present invention relates to novel classes of carboxylic acid derivatives of the general formulae {alpha} and {beta}, which are inhibitors of an enzyme converting interleukin-1{beta}, and pharmaceutical preparations containing thereof. The compounds and pharmaceutical preparations according to the present invention are especially suited for inhibition of ICE activity and they can be therefore preferably used as agents against diseases mediated by interleukin-1 or apoptosis, inclusive of inflammatory diseases, autoimmune diseases, and proliferation disorders, infectious and degenerative diseases.