公开(公告)号：BRPI1011993A2

公开(公告)日：2021-07-06

申请号：BRPI1011993

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： BRIAN LEDFORD ,  CHAO LIN ,  DYLAN H JACOBS ,  EMANUELE PEROLA ,  FRANÇOIS MALTAIS ,  HONGBO DENG ,  HUAI GAO ,  IOANA DRUTU ,  JOHN J COURT ,  JOHN P DUFFY ,  JOSEPH M KENNEDY ,  LUC FARMER ,  M WOODS WANNAMAKER ,  MARK W LEDEBOER ,  MICHAEL P CLARK ,  MIN JIANG ,  PAUL CHARIFSON ,  RANDAL BYRN ,  RANDY S BETHIEL ,  STEVEN JONES ,  TIANSHENG WANG ,  UPUL K BANDARAGE ,  URSULA A GERMANN ,  WENXIN GU ,  YI ZHOU

IPC: A61K31/506 ,  A61P31/16

Abstract: inibidores de replicação do vírus influenza, seu uso, método de preparação dos mesmos e composição farmacêutica que os compreende. a invenção refere-se a métodos de inibição da replicação de vírus influenza em uma amostra biológica ou paciente, de redução da quantidade de vírus influenza em uma amostra biológica ou paciente e de trata-mento de influenza em um paciente compreendendo administrar à dita a-mostra biológica ou paciente uma quantidade eficaz de um composto representado pela fórmula estrutural (i): ou um sal farmaceuticamente aceitável do mesmo, onde os valores da fórmula estrutura (ia) são conforme aqui descrito. um composto é representado pela fórmula estrutural (ia) ou um sal farmaceuticamente aceitável do mesmo, onde os valores de fórmula es-trutural (ia) são conforme aqui descrito. uma composição farmacêutica compreendendo uma quantidade eficaz de tal composto ou sal farmaceuti-camente aceitável do mesmo e um carreador, adjuvante ou veículo farma-ceuticamente aceitável.

公开(公告)号：ZA200705116B

公开(公告)日：2008-06-25

申请号：ZA200705116

申请日：2007-06-18

Applicant: VERTEX PHARMA

Inventor： IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  AKIKO NAKATANI ,  HURLEY DENNIS J ,  BERGERON DANIELE M ,  DAVIES ROBERT J ,  MAKINGS LEWIS R ,  GABRIEL RAFFAI

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：PT3141252T

公开(公告)日：2018-11-14

申请号：PT16181549

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： FRANCESCO G SALITURO ,  PAUL CHARIFSON ,  MARK W LEDEBOER ,  TIANSHENG WANG ,  LUC FARMER ,  ANN D KWONG ,  CHAO LIN ,  YI ZHOU ,  MARION W WANNAMAKER ,  BRIAN LEDFORD ,  FRANCOIS MALTAIS ,  HUAI GAO ,  MICHAEL P CLARK ,  UPUL K BANDARAGE ,  RANDY S BETHIEL ,  JOHN J COURT ,  HONGBO DENG ,  IOANA DRUTU ,  JOHN P DUFFY ,  WENXIN GU ,  DYLAN H JACOBS ,  JOSEPH M KENNEDY ,  EMANUELE PEROLA ,  RANDAL BYRN ,  MIN JIANG ,  URSULA A GERMANN ,  STEVEN JONES

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：PT2442809T

公开(公告)日：2016-12-06

申请号：PT10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： MARK W LEDEBOER ,  PAUL CHARIFSON ,  MICHAEL P CLARK ,  UPUL K BANDARAGE ,  RANDY S BETHIEL ,  HONGBO DENG ,  JOHN J COURT ,  IOANA DRUTU ,  JOHN P DUFFY ,  LUC FARMER ,  HUAI GAO ,  WENXIN GU ,  DYLAN H JACOBS ,  JOSEPH M KENNEDY ,  BRIAN LEDFORD ,  FRANCOIS MALTAIS ,  EMANUELE PEROLA ,  TIANSHENG WANG ,  M WOODS WANNAMAKER ,  RANDAL BYRN ,  YI ZHOU ,  CHAO LIN ,  MIN JIANG ,  URSULA A GERMANN ,  STEVEN JONES ,  FRANCESCO G SALITURO ,  ANN DAK-YEE KWONG

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：TR201815272T4

公开(公告)日：2018-11-21

申请号：TR201815272

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： PAUL CHARIFSON ,  P MICHAEL CLARK ,  K UPUL BANDARAGE ,  S RANDY BETHIEL ,  J JOHN COURT ,  HONGBO DENG ,  IOANA DRUTU ,  P JOHN DUFFY ,  LUC FARMER ,  HUAI GAO ,  WENXIN GU ,  H DYLAN JACOBS ,  M JOSEPH KENNEDY ,  W MARK LEDEBOER ,  BRIAN LEDFORD ,  FRANCOIS MALTAIS ,  EMANUELE PEROLA ,  TIANSHENG WANG ,  WOODS M WANNAMAKER ,  RANDAL BYRN ,  YI ZHOU ,  CHAO LIN ,  MIN JIANG ,  A URSULA GERMANN ,  STEVEN JONES ,  FRANCESCO G SALITURO ,  ANN DAK-YEE KWONG

IPC: A61K31/506 ,  A61P31/16

Abstract: Biyolojik bir numunede veya hastada influenza virüslerinin replikasyonunun inhibe edilmesi, biyolojik bir numunede veya hastada influenza virüslerinin miktarının düşürülmesi ve bir hastada influenzanın tedavi edilmesine yönelik yöntemler, söz konusu biyolojik numune veya hastaya, Yapısal Formül (I) ile gösterilen bir bileşiğin etkili bir miktarının: veya bunun farmasötik olarak kabul edilebilir bir tuzunun uygulanmasını içerir, burada Yapısal Formülün (IA) değerleri, burada açıklandığı gibidir. Bir bileşik, Yapısal Formül (IA) veya farmasötik olarak kabul edilebilir bir tuzu ile gösterilir, burada Yapısal Formülün (IA) değerleri, burada açıklandığı gibidir. Farmasötik bir bileşim, bu tür bir bileşiğin veya farmasötik olarak kabul edilebilir bir tuzunun etkili miktarını ve farmasötik olarak kabul edilebilir bir taşıyıcı, adjuvan veya aracı içerir.

公开(公告)号：AU2010262905A1

公开(公告)日：2012-01-12

申请号：AU2010262905

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： PAUL CHARIFSON ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  HONGBO DENG ,  IOANA DRUTU ,  DUFFY JOHN P ,  LUC FARMER ,  HUAI GAO ,  WENXIN GU ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  BRIAN LEDFORD ,  FRANCOIS MALTAIS ,  EMANUELE PEROLA ,  TIANSHENG WANG ,  WOODS WANNAMAKER M ,  RANDAL BYRN ,  YI ZHOU ,  CHAO LIN ,  MIN JIANG ,  STEVEN JONES ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：AU2005309365B2

公开(公告)日：2011-10-06

申请号：AU2005309365

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  GABRIEL RAFFAI ,  AKIKO NAKATANI ,  MAKINGS LEWIS R ,  IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  BERGERON DANIELE M

IPC: C07D471/00 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4747 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200807236B

公开(公告)日：2009-08-26

申请号：ZA200807236

申请日：2008-08-21

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

公开(公告)号：ZA200806028B

公开(公告)日：2009-04-29

申请号：ZA200806028

申请日：2008-07-10

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.