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21.发明专利
公开(公告)号：DK1993360T3
公开(公告)日：2017-05-22
申请号：DK06848237
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
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公开(公告)号：NZ597823A
公开(公告)日：2014-05-30
申请号：NZ59782310
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: 597823 Disclosed herein are pharmaceutical compositions comprising a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1) for use treating or lessening the severity of cystic fibrosis in a patient, and method of manufacturing said compositions. In a preferred embodiment the patient possesses a cystic fibrosis transmembrane receptor (CFTR) with a &Dgr;F508 mutation or G551D mutation on both alleles.
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公开(公告)号：CA2769695A1
公开(公告)日：2011-02-17
申请号：CA2769695
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F , VERWIJS MARINUS JACOBUS
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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24.发明专利
公开(公告)号：CA2635581A1
公开(公告)日：2007-07-12
申请号：CA2635581
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： CONNELLY PATRICK , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , HURTER PATRICIA , YOUNG CHRISTOPHER R , FENG YUSHI , TRUDEAU MARTIN , ROWE WILLIAM
IPC: A01N43/40 , A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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公开(公告)号：HUE049976T2
公开(公告)日：2020-11-30
申请号：HUE17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
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Patent Agency Ranking
公开(公告)号：ES2790700T3
公开(公告)日：2020-10-28
申请号：ES17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
Abstract: Una composición farmacéutica que comprende N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa; en la que N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa tiene menos del 30 % de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida cristalina.
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27.发明专利
公开(公告)号：AU2020201314A1
公开(公告)日：2020-03-12
申请号：AU2020201314
申请日：2020-02-21
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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公开(公告)号：RS58604B1
公开(公告)日：2019-05-31
申请号：RSP20190432
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：DK2464337T3
公开(公告)日：2019-04-23
申请号：DK10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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30.发明专利
公开(公告)号：AU2018204203A1
公开(公告)日：2018-07-05
申请号：AU2018204203
申请日：2018-06-13
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1 -dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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