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    제초활성을 갖는 5-벤질옥시메틸-1,2-이속사졸린 유도체화합물
    31.
    发明授权
    제초활성을 갖는 5-벤질옥시메틸-1,2-이속사졸린 유도체화합물 有权
    제초활성을갖는5- 5벤질옥시메틸-1,2-이속사졸린유도체화

    公开(公告)号：KR100392072B1

    公开(公告)日：2003-07-22

    申请号：KR1020000052917

    申请日：2000-09-07

    Applicant: 한국화학연구원

    Inventor： 유응걸 ,  김형래 ,  전동주 ,  송종환 ,  김경만 ,  이정노 ,  김형철 ,  홍경식

    IPC: A01N43/80

    CPC classification number: A01N43/80

    Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.

    Abstract translation: 本发明提供了式（1）的新型5-苄氧基甲基-1,2-异恶唑啉衍生物及其制备方法和它们作为除草剂的用途。 即使在低剂量率下，本发明的5-苄氧基甲基-1,2-异恶唑啉衍生物对稻田杂草具有足够高的除草活性，特别是对转移的稻米具有优异的选择性。 因此，本发明的化合物通常可用作除草剂以控制稻中的稻田杂草。

    제초활성을 갖는 Ｎ-(5-이속사졸리닐메틸옥시페닐)-디메틸말레이미드 유도체
    32.
    发明公开
    제초활성을 갖는 Ｎ-(5-이속사졸리닐메틸옥시페닐)-디메틸말레이미드 유도체 失效
    衍生于除草活性的N-（5-异丙氧基苯基）乙酰基苯基）二甲基亚胺

    公开(公告)号：KR1020000059735A

    公开(公告)日：2000-10-05

    申请号：KR1019990007558

    申请日：1999-03-08

    Applicant: 한국화학연구원

    Inventor： 유응걸 ,  송종환 ,  김형래 ,  전동주 ,  정정애 ,  김경만 ,  김태준

    IPC: C07D413/12

    Abstract: PURPOSE: A N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is provided which has excellent stability against a rice plant and shows good herbicidal activity on weeds in a paddy like echor, scpju, moova, cypse, sagpy or so on. CONSTITUTION: The N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is shown in a chemical formula 1 wherein R is alkyl radical with 1-5 carbon number, phenyl radical or substituted phenyl radical, cyano radical, carboxylic acid or carboxylic ester, heterocyclic or substituted heterocyclic radical. The substituted phenyl radical or substituted heterocyclic radical is simply or mixedly substituted from 1-3 radicals among alkyl radical with 1-3 carbon number, alkoxy radial with 1-3 carbon number, halogen atom, cyano radical, nitro radical, carboxyl radical and carboxylic ester.

    Abstract translation: 目的：提供一种对水稻植株具有优异稳定性的N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物，对水稻，scpju，moova，cypse，sagpy等中的杂草具有良好的除草活性。 组成：N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物以化学式1表示，其中R是具有1-5个碳数的烷基，苯基或取代的苯基，氰基，羧酸或羧酸酯，杂环或 取代的杂环基。 取代的苯基或取代的杂环基团在具有1-3个碳原子的烷基，具有1-3个碳数的烷氧基，卤素原子，氰基，硝基，羧基和羧基的烷基中简单或混合取代1-3个基团 酯。

    2,3-디히드로-3-메틸렌-2-치환된 페닐-1H-이소인돌-1-온 유도체
    34.
    发明授权
    2,3-디히드로-3-메틸렌-2-치환된 페닐-1H-이소인돌-1-온 유도체 失效
    2.3-二氢-3-乙烯基-2-取代的苯基-1H-1衍生物

    公开(公告)号：KR100128544B1

    公开(公告)日：1998-04-04

    申请号：KR1019940016984

    申请日：1994-07-14

    Applicant: 한국화학연구원

    Inventor： 유응걸 ,  김재녕 ,  이수영 ,  황인택 ,  김형래 ,  김경만 ,  송종환

    IPC: C07D209/32 ,  C07D209/42

    Abstract: Title derivatives(I; R1, R2= same or not, H, fluro, chlorro, bromo, C1-3 alkyl, C1-3 alkoxy; R1 and R2 are formed a fused ring such as -CH=CH-CH=CH-; R3= H, C1-4 alkyl, C3-6 alkenyl, etc.), useful as herbicides were prepared. Thus, 3.03 g 4-fluorophenol was reacted with 1.9 ml ethyl chloride, followed by addition of 4.0 g anhydrous aluminium chloride at 180 deg.C for 30 minutes to give 2.71 g 2-hydroxy-5-fluoroacetophenone(III). III and 1.05 g ethyl carbamate were refluxed for 20- 30 hours in 50 ml n-propanol to give ethoxycarbonylhydrazone derivatives IV. 2.41 g IV was dissolved in 100 ml tetrahydrofuran, adding 4.44 g (CH3COO)4Pb as an oxidation agent at room temperature for 3- 5 hours to give ethyl 0-acetylarylcarboxylate derivatives(V). 2.1 g V and 0.83 g 4-chloro-2-fluoro-5-hydroxyaniline were refluxed for 20- 30 hours in a mixed solvent of 50 ml o-dichlorobenzene and acetic acid to give 2,3-dihydro-3-methylene- 2-(4-chloro-2-fluoro-3-hydroxyphenyl)-1H-isoindol-1-one(VII). VII was refluxed for 20 hours to give 2,3-dihydro-3-methylene-2- (3-propagyloxy-4-chloro-2-fluorophenyl)-1H-isoindol-1-one(I).

    Abstract translation: 标题衍生物（I; R1，R2 =相同或不同，H，氟，氯，溴，C1-3烷基，C1-3烷氧基; R1和R2形成稠环，例如-CH = CH-CH = CH- ; R3 = H，C1-4烷基，C3-6烯基等），可用作除草剂。 因此，将3.03g 4-氟苯酚与1.9ml氯乙烷反应，然后在180℃下加入4.0g无水氯化铝30分钟，得到2.71g 2-羟基-5-氟苯乙酮（III）。 III和1.05g氨基甲酸乙酯在50ml正丙醇中回流20-30小时，得到乙氧基羰基腙衍生物IV。 将2.41g IV溶解在100ml四氢呋喃中，在室温下加入4.44g（CH3COO）4Pb作为氧化剂，持续3-5小时，得到O-乙酰基芳基羧酸乙酯衍生物（V）。 将2.1g V和0.83g 4-氯-2-氟-5-羟基苯胺在50ml邻二氯苯和乙酸的混合溶剂中回流20-30小时，得到2,3-二氢-3-亚甲基-2 - （4-氯-2-氟-3-羟基苯基）-1H-异吲哚-1-酮（VII）。 VII的混合物回流20小时，得到2,3-二氢-3-亚甲基-2-（3-羰基氧基-4-氯-2-氟苯基）-1H-异吲哚-1-酮（I）。

    신규한 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 이상지질혈증의 예방 또는 치료용 약학적 조성물
    39.
    发明授权
    신규한 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 이상지질혈증의 예방 또는 치료용 약학적 조성물 有权
    新型吲哚衍生物及其制备方法以及用于预防或治疗含有其作为活性成分的血脂异常的药物组合物

    公开(公告)号：KR101448015B1

    公开(公告)日：2014-10-08

    申请号：KR1020130041609

    申请日：2013-04-16

    Applicant: 한국화학연구원

    Inventor： 이선경 ,  송종환 ,  조희영 ,  김현영

    IPC: C07D413/06 ,  C07D403/06 ,  A61K31/4245 ,  A61P3/06

    Abstract: The present invention relates to a novel indole derivative or a pharmaceutically allowable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating dyslipidemia containing the same as an active ingredient. The novel indole derivative according to the present invention combines a niacin GPR109A receptor, activates the receptor, and induces less activation of beta-arrestin signal transduction pathway, thereby minimizing a facial blushing side effect and being used as a composition for preventing, alleviating, or treating dyslipidemia such as hyperlipemia, hypercholesterinemia, hypertriglyceridemia, etc.

    Abstract translation: 本发明涉及一种新的吲哚衍生物或其药学上允许的盐，其制备方法和用于预防或治疗含有其的活性成分的血脂异常的药物组合物。 根据本发明的新型吲哚衍生物结合了烟酸GPR109A受体，激活受体，并诱导较少的β-抑制蛋白信号转导途径的活化，从而使脸部脸红的副作用最小化，并用作预防，缓解或 治疗血脂异常，如高脂血症，高胆固醇血症，高甘油三酯血症等

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