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公开(公告)号：KR101251589B1
公开(公告)日：2013-04-08
申请号：KR1020120108010
申请日：2012-09-27
Applicant: 한국화학연구원
Abstract: 본 발명은 도라지 또는 도라지 추출물로부터의 순도 및 유효 사포닌 함량이 증가된 조사포닌 조성물의 제조방법에 관한 것으로, 더욱 구체적으로 상기 제조방법은 도라지로부터 착즙공정 또는 증류수, C
1 내지 C
3 의 저급알코올, 에틸아세테이트, 핵산, 디클로로메탄 또는 이들의 혼합용매를 이용하여 도라지 추출물을 수득하는 단계(단계 1); 상기 단계 1에서 수득한 추출물을 증류수에 용해시킨 후 역상겔이 충진된 컬럼에 가하여 사포닌 성분을 흡착시키는 흡착공정 및 흡착된 사포닌을 에탄올 또는 메탄올 수용액으로 용출시키는 용출공정을 포함하는 사포닌을 수득하는 단계(단계 2); 및 상기 단계 2에서 수득한 사포닌을 유기용매를 사용하여 정제하는 단계(단계 3)를 포함한다. 본 발명은 도라지 추출물을 부탄올로 추출하는 종래의 조사포닌 제조방법에 비하여 순도가 높을 뿐만 아니라 유효 사포닌 함량이 증가된 조사포닌 조성물을 얻을 수 있으므로 도라지 또는 도라지 추출물로부터 사포닌 추출시 유용하게 활용될 수 있다.-
公开(公告)号：KR101077913B1
公开(公告)日：2011-10-31
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: 본발명은토양메타게놈유래신규에스터라제(esterase) 유전자및 이로부터암호화되는에스터라제단백질에관한것으로, 보다상세하게는토양미생물의총 유전체인메타게놈으로부터분리한신규에스터라제가우수한에스터라제활성을나타내고, 온도, pH 및유기용매에대한효소활성안정성을나타내며, 짧은사슬(short chain) 지방산을가지는지질및 3-하이드록시팔미트산메틸에스테르(3-OH palmitic acid methyl ester; 3-OH PAME)를분해하여식물병원성균에대한바이오필름저해활성을나타냄으로써식물세균병저항성작물또는식물세균병제어제개발에유용하게사용될수 있다.
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公开(公告)号：KR1020100091749A
公开(公告)日：2010-08-19
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: PURPOSE: A soil metagenome-derived novel esterase gene is provided to ensure enzyme activity stability and to use in developing an agent which controls plant bacterial diseases. CONSTITUTION: A polypeptide having esterase activity comprises: a polypeptide encoded by polynucleotide of sequence number 1; a polypeptide encoded by a polynucleotide which is hybridized with the polynucleotide of sequence number 1; and a polypeptide with an amino acid sequence of sequence number 2. A method for preparing a recombinant esterase comprises: a step of preparing a recombinant expression vector containing the polynueotide; a step of preparing a transformant by introducing a recombinant expression vector to host cells; and a step of culturing the transformant to induce recombinant protein expression.
Abstract translation: 目的：提供一种土壤巨蛋白衍生新型酯酶基因，以确保酶活性的稳定性，并用于开发控制植物细菌性疾病的药剂。 构成：具有酯酶活性的多肽包括：由序列号1的多核苷酸编码的多肽; 由与序列号1的多核苷酸杂交的多核苷酸编码的多肽; 和具有序列号2的氨基酸序列的多肽。制备重组酯酶的方法包括：制备含有多核苷酸的重组表达载体的步骤; 通过将重组表达载体引入宿主细胞来制备转化体的步骤; 以及培养转化体诱导重组蛋白表达的步骤。
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34.发明公开상엽 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 식욕 억제, 우울증의 예방 및 개선, 또는 불안증의 예방 및 개선용 식품 조성물 失效含有作为活性成分的以MCH受体拮抗活性为基础的MORI FOLIUM，其分离物或其化合物或其化合物用于预防或改善代谢或饮食障碍的饮食组合物
公开(公告)号：KR1020100024793A
公开(公告)日：2010-03-08
申请号：KR1020080083509
申请日：2008-08-26
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2200/332 , A23V2250/21
Abstract: PURPOSE: A food composition for preventing and improving of a metabolic disorder and an eating disorder based on MCH receptor antagonistic activity is provided to improve and prevent coronary artery diseases, hyperlipidemia, degenerative arthritis, melancholia, anxiety, and mental anxiety etc. CONSTITUTION: A food composition contains mulberry leaf extract extracted with a solvent including water, an organic solvent, or a mixture of water and the organic solvent as a beneficial component. The organic solvent is alcohol of C1-C4, dichloromethane or ethyl acetate. The alcohol of C1-C4 is methanol or ethanol. The mulberry leaf materials is produced by separating the mulberry leaf extract with dichloromethane.
Abstract translation: 目的：提供一种用于预防和改善基于MCH受体拮抗活性的代谢紊乱和进食障碍的食物组合物，用于改善和预防冠状动脉疾病，高脂血症，退行性关节炎，忧郁症，焦虑和精神焦虑等。构成：A 食品组合物含有用溶剂，包括水，有机溶剂或水和有机溶剂的混合物萃取的桑叶提取物作为有益成分。 有机溶剂是C1-C4的醇，二氯甲烷或乙酸乙酯。 C1-C4的醇是甲醇或乙醇。 通过将桑叶提取物与二氯甲烷分离来生产桑叶。
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35.发明公开[10]-진저다이온 또는 1-데하이드로-[10]-진저다이온을 포함하는 항 염증용 조성물 有权用于抗炎，组织改善的组合物，来自手术或布鲁斯的加速恢复，或治疗或预防心脏疾病，包括分离的ZINGIBER OFFICINALE或活性化合物的提取物
公开(公告)号：KR1020090104373A
公开(公告)日：2009-10-06
申请号：KR1020080029772
申请日：2008-03-31
Applicant: 한국화학연구원
IPC: A61K31/12 , A61K36/9068
CPC classification number: A61K31/12 , A23L2/52 , A23L29/035 , A61K36/9068 , Y10S514/886
Abstract: PURPOSE: A composition for treating or preventing heart diseases or for anti-inflammation, topical edema reduction, treatment or prevention of heart diseases is provided to enhance uptake function of macrophage and remove waste from the body. CONSTITUTION: A pharmaceutical composition for preventing or treating heart diseases or for anti-inflammation, topical edema reduction, or recovery promotion from surgery or contusion contains [10]-gingerdione of the chemical formula 1, 1-dehydro-[10]-gingerdione of the chemical formula 2 or their composite.
Abstract translation: 目的：提供用于治疗或预防心脏病或抗炎，局部水肿减轻，治疗或预防心脏病的组合物，以增强巨噬细胞的摄取功能，并从体内清除废物。 构成：用于预防或治疗心脏病或用于抗炎，局部水肿减轻或从手术或挫伤中恢复促进的药物组合物含有化学式1，1-dehydro- [10] - 二烯酮的[10] 化学式2或其复合物。
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Patent Agency Ranking
公开(公告)号：KR100891762B1
公开(公告)日：2009-04-07
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: 본 발명은 마칠린 디 (machilin D), 사우스네올 디 (saucerneol D) 및 이들의 혼합물로 구성된 군으로부터 선택된 화합물 또는 이를 포함하는 삼백초 (
Saururus chinenesis ) 뿌리 추출물을 유효성분으로 함유하는 혈관 이완용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압 강하효과를 나타내므로, 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 또는 건강 식품 조성물로 유용하게 사용될 수 있다.-
公开(公告)号：KR100457069B1
公开(公告)日：2004-11-10
申请号：KR1020010054440
申请日：2001-09-05
Applicant: 한국화학연구원
IPC: A01N63/02
Abstract: PURPOSE: Provided are a novel Pythium myriotylum strain, a pathogen of plants, and a method for the biological control of weeds using same, thereby effectively and selectively removing weeds from a rice field. CONSTITUTION: The novel strain, Pythium myriotylum MD2(KCTC 10034BP) is used for selectively controlling weeds selected from American black cherry, Monochoria vaginalis, yellow birtch, Chondostereum purpureum, Northern joint vetch, Colletotrichum gloeosporioides f. sp. aeschynomene, Morrenia odorata, Phyrophthora palmivora, Poa annua, Pseudomonas gladioli, etc.
Abstract translation: 用途：提供了一种新型的Pythium myriotylum菌株，植物病原体，以及使用它的生物防治杂草的方法，由此有效地选择性地从稻田中除去杂草。 组成：新菌株Pythium myriotylum MD2（KCTC 10034BP）用于选择性控制选自美国黑樱桃，Monochoria vaginalis，黄色birtch，Chondostereum purpureum，Northern joint vetch，Colletotrichum gloeosporioides f。 SP。 aeschynomene，Morrenia odorata，Phyrophthora palmivora，Poa annua，唐菖蒲假单胞菌等
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公开(公告)号：KR100392072B1
公开(公告)日：2003-07-22
申请号：KR1020000052917
申请日：2000-09-07
Applicant: 한국화학연구원
IPC: A01N43/80
CPC classification number: A01N43/80
Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.
Abstract translation: 本发明提供了式（1）的新型5-苄氧基甲基-1,2-异恶唑啉衍生物及其制备方法和它们作为除草剂的用途。 即使在低剂量率下，本发明的5-苄氧基甲基-1,2-异恶唑啉衍生物对稻田杂草具有足够高的除草活性，特别是对转移的稻米具有优异的选择性。 因此，本发明的化合物通常可用作除草剂以控制稻中的稻田杂草。
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公开(公告)号：KR1020010026621A
公开(公告)日：2001-04-06
申请号：KR1019990038013
申请日：1999-09-08
Applicant: 한국화학연구원
IPC: C07C323/10
Abstract: PURPOSE: The title compound having a new structure in which a sulfide or sulfon group substituted fluorinated vinyl group is introduced into oxyacetamide derivatives and herbicidal composition containing the same as an effective component are provided which have excellent herbicidal activity. CONSTITUTION: The sulfide or sulfon group substituted fluorinated vinyloxyacetamide derivatives of formula 1 is prepared by a process consisting of: reacting alcoholic compounds of formula 2 and fluorinated vinyl compounds of formula 3 in the presence of a base. In formula, R1 is C1-4 alkyl, C2-4 alkenyl or nonsubstituted or C1-4 alkyl, haloalkyl, alkoxy, Cl, F or F substituted phenyl; R2 is C1-4 alkyl or C2-4 alkenyl; R3 is C1-4 alkyl or phenyl; R4 is C1-4 alkyl or, nonsubstituted Cl, F or Br substituted phenyl; R5 is F or trifluormethyl; n is 0 or 2.
Abstract translation: 目的：提供具有硫化物或磺基取代的氟代乙烯基的新结构的标题化合物引入氧乙酰胺衍生物中，并且含有其作为有效成分的除草组合物具有优异的除草活性。 构成：式1的硫化物或磺基取代的氟化乙烯氧基乙酰胺衍生物通过以下方法制备：在碱的存在下使式2的醇类化合物与式3的氟化乙烯基化合物反应。 在式中，R 1为C 1-4烷基，C 2-4烯基或未取代的或C 1-4烷基，卤代烷基，烷氧基，Cl，F或F取代的苯基; R2是C1-4烷基或C2-4烯基; R3是C1-4烷基或苯基; R 4是C 1-4烷基或未取代的Cl，F或Br取代的苯基; R5是F或三氟甲基; n为0或2。
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公开(公告)号：KR100248945B1
公开(公告)日：2000-04-01
申请号：KR1019970065413
申请日：1997-12-02
Applicant: 한국화학연구원
IPC: A01N43/76
Abstract: 본 발명은 화학식 1로 표시되는 제초성 3-아릴-테트라히드로-1,2-벤즈이속사졸린-4-온 유도체에 관한 것이다.
상기식에서 Xn은 수소, C
1 -C
4 알킬기, C
2 -C
5 알케닐기, C
2 -C
5 알키닐기, C
1 -C
4 알콕시기, C
1 -C
4 할로알킬기, C
1 -C
4 알콕시카보닐기, 아미노카보닐기, 카복시기, 메탄설포닐기, 니트로기, 히드록시기, 니트릴기, 또는 이들의 둘이상의 복합치환기를 나타낸다.
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