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公开(公告)号：UY34043A
公开(公告)日：2012-10-31
申请号：UY34043
申请日：2012-04-27
Applicant: ABBOTT LAB
Inventor： BREINLINGER ERIC C , CALDERWOOD DAVID J , SWANN STEVEN L , SUBHENDU MUKHERJEE , CHITTY VENKATA SRIKANTH , THUNUGUNTLA SIVA SANJEEVA RAO , HOSAHALLI SUBRAMANYAH SEETHARAMA SHASTRY
IPC: A61K31/357 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/4453 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D239/36 , C07D257/04 , C07D261/04 , C07D295/096 , C07D319/06 , C07D333/14 , C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
Abstract: En una realización la invención provee un compuesto de Fórmula I, metabolitos biológicamente activos, prodrogas, isómeros, estereoisómeros, solvatos, hidratos y sales farmacéuticamente aceptables del mismo donde las variables se han definido en la presente. Los compuestos de la invención son útiles para tratar condiciones inmunológicas.
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公开(公告)号：SG177221A1
公开(公告)日：2012-01-30
申请号：SG2011094539
申请日：2007-12-14
Applicant: ABBOTT LAB
Inventor： HOBSON ADRIAN D , FIX-STENZEL SHANNON , CUSACK KEVIN P , BREINLINGER ERIC C , ANSELL GRAHAM K , STOFFEL ROBERT H , WOLLER KEVIN R , GRONGSAARD PINTIPA
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the SIP family of G protein-coupled receptors for treating diseases associated with modulation of SIP family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
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公开(公告)号：CA2783851A1
公开(公告)日：2011-06-16
申请号：CA2783851
申请日：2010-08-24
Applicant: ABBOTT LAB
Inventor： CUSACK KEVIN P , BREINLINGER ERIC C , FIX-STENZEL SHANNON R , STOFFEL ROBERT H , WOLLER KEVIN R
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
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公开(公告)号：DOP2009000149A
公开(公告)日：2010-05-15
申请号：DO2009000149
申请日：2009-06-19
Applicant: ABBOTT LAB
Inventor： WALLACE GRIER A , BREINLINGER ERIC C , CUSACK KEVIN P , FIX-STENZEL SHANNON R , GORDON THOMAS D , HOBSON ADRIAN D , HAYES MARTIN E , ANSELL GRAHAM K , GRONGSAARD PINTIPA
Abstract: La presente invención se refiere a agentes novedosos, potentes y selectivos que son agonistas o antagonistas de los uno o més receptores individuales de la familia de receptores SIP. Los compuestos de la invención son útiles como agentews terapéuticos por el tratamiento de trastornos clínicos asociados con el agonismo o antagonismo de receptores individuales de la familia de receptore S1P.
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公开(公告)号：ZA200903693B
公开(公告)日：2010-03-31
申请号：ZA200903693
申请日：2009-05-27
Applicant: ABBOTT LAB
Inventor： HOBSON ADRIAN D , FIX-STENZEL SHANNON , CUSACK KEVIN P , BREINLINGER ERIC C , ANSELL GRAHAM K , STOFFEL ROBERT H , WOLLER KEVIN R , GRONGSAARD PINTIPA
IPC: A01N20100101 , A61K20100101
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
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Patent Agency Ranking
公开(公告)号：MX2009010362A
公开(公告)日：2009-10-16
申请号：MX2009010362
申请日：2008-03-27
Applicant: ABBOTT LAB
Inventor： BETSCHMANN PATRICK , CALDERWOOD DAVID J , DIXON RICHARD W , FRANK KRISTINE E , BREINLINGER ERIC C
IPC: A01N43/58 , A61K31/50 , C07D471/00
Abstract: La presente invención está dirigida a compuestos de imidazopirazina novedosos útiles como inhibidores de cinasa y podrían ser útiles en el tratamiento de ciertas condiciones y enfermedades, especialmente condiciones y enfermedades inflamatorias y trastornos y condiciones proliferativas, por ejemplo, cánceres.
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公开(公告)号：PE20081561A1
公开(公告)日：2008-10-30
申请号：PE2008000051
申请日：2008-01-02
Applicant: ABBOTT LAB
Inventor： WALLACE GRIER A , CUSACK KEVIN P , GORDON THOMAS D , BREINLINGER ERIC C , FIX-STENZEL SHANNON R , HOBSON ADRIAN D , ANSELL GRAHAM K , HAYES MARTIN E , GRONGSAARD PINTIPA
IPC: C07D205/00 , C07D207/00 , C07D211/00 , C07D229/00 , C07D231/00 , C07D237/00
Abstract: REFERIDA A UN DERIVADO DE FENILO DE FORMULA (I), DONDE D ES H, N(R5)2, OR6; X ES CH, C(CH3), N; A ES H, OH, CH2OH, C(O)-OCH3, ENTRE OTROS; Y ES CH2. O, S, NR3; R1 Y R2 SON H, CF3, HALOGENO, ALQUILO C1-C20, ENTRE OTROS; m ES 1 O 2; u ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: [(1R,3S)-1-AMINO-3-(4-OCT-1-INIL-FENIL)CICLOPENTIL]METANOL, [(1R,3S)-1-AMINO-3-(4-OCTIL-FENIL)CICLOPENTIL]METANOL, {(1R,3S)-1-AMINO-3-[4-(3-FENOXI-PROPIL)FENIL]CICLOPENTIL}METANOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS Y ANTAGONISTAS DE LOS RECEPTORES DE ESFINGOSINA-1-FOSFATO (S1P) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, ARTRITIS, LUPUS ERITEMATOSO SISTEMICO, ASMA, ENTRE OTROS
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公开(公告)号：PE15612008A1
公开(公告)日：2008-10-30
申请号：PE0000512008
申请日：2008-01-02
Applicant: ABBOTT LAB
Inventor： WALLACE GRIER A , CUSACK KEVIN P , GORDON THOMAS D , BREINLINGER ERIC C , FIX-STENZEL SHANNON R , HOBSON ADRIAN D , ANSELL GRAHAM K , HAYES MARTIN E , GRONGSAARD PINTIPA
IPC: C07D205/00 , C07D207/00 , C07D211/00 , C07D229/00 , C07D231/00 , C07D237/00
CPC classification number: C07D413/04 , C07C215/38 , C07C215/42 , C07C217/52 , C07C217/74 , C07C229/14 , C07C229/48 , C07C2601/02 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D207/14 , C07D213/30 , C07D263/32 , C07D263/52 , C07D271/06 , C07D307/22 , C07D307/24 , C07D333/16 , C07D491/107 , C07F9/091 , C07F9/301 , C07F9/3808 , C07F9/3826 , C07F9/4006 , C07F9/653 , C07F9/65515 , C07F9/655345
Abstract: REFERIDA A UN DERIVADO DE FENILO DE FORMULA (I), DONDE D ES H, N(R5)2, OR6; X ES CH, C(CH3), N; A ES H, OH, CH2OH, C(O)-OCH3, ENTRE OTROS; Y ES CH2. O, S, NR3; R1 Y R2 SON H, CF3, HALOGENO, ALQUILO C1-C20, ENTRE OTROS; m ES 1 O 2; u ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: [(1R,3S)-1-AMINO-3-(4-OCT-1-INIL-FENIL)CICLOPENTIL]METANOL, [(1R,3S)-1-AMINO-3-(4-OCTIL-FENIL)CICLOPENTIL]METANOL, {(1R,3S)-1-AMINO-3-[4-(3-FENOXI-PROPIL)FENIL]CICLOPENTIL}METANOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS Y ANTAGONISTAS DE LOS RECEPTORES DE ESFINGOSINA-1-FOSFATO (S1P) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, ARTRITIS, LUPUS ERITEMATOSO SISTEMICO, ASMA, ENTRE OTROS
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公开(公告)号：AU2007338700A1
公开(公告)日：2008-07-03
申请号：AU2007338700
申请日：2007-12-21
Applicant: ABBOTT LAB
Inventor： BREINLINGER ERIC C , GRONGSAARD PINTIPA , ANSELL GRAHAM K , HAYES MARTIN E , FIX-STENZEL SHANNON R , WALLACE GRIER A , HOBSON ADRIAN D , CUSACK KEVIN P , GORDON THOMAS D
IPC: A01N43/50 , A61K31/415
Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
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公开(公告)号：AU2007334436A1
公开(公告)日：2008-06-26
申请号：AU2007334436
申请日：2007-12-14
Applicant: ABBOTT LAB
Inventor： FIX-STENZEL SHANNON , WOLLER KEVIN R , BREINLINGER ERIC C , GRONGSAARD PINTIPA , CUSACK KEVIN P , HOBSON ADRIAN D , STOFFEL ROBERT H , ANSELL GRAHAM K
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
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