公开(公告)号：CA2756178A1

公开(公告)日：2010-09-30

申请号：CA2756178

申请日：2010-03-26

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  LI TONGMEI ,  LIU BO ,  PEDDI SRIDHAR ,  WANG XUEQING ,  KOLASA TEODOZYI ,  NELSON DEREK W ,  PEREZ-MEDRANO ARTURO

IPC: C07D405/06 ,  A61K31/433 ,  A61P25/04 ,  C07D413/06 ,  C07D417/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

公开(公告)号：CA2737199A1

公开(公告)日：2010-03-25

申请号：CA2737199

申请日：2009-09-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

IPC: C07D231/40 ,  A61K31/4155 ,  A61K31/433 ,  A61P29/00 ,  C07D285/135 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：CA2734527A1

公开(公告)日：2010-03-11

申请号：CA2734527

申请日：2009-09-08

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  PEDDI SRIDHAR

IPC: C07D277/46 ,  A61K31/427 ,  A61P29/00 ,  C07D417/06 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X1, A1, Rx, R2, R3, R4, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

公开(公告)号：MX2009010363A

公开(公告)日：2009-12-04

申请号：MX2009010363

申请日：2008-03-19

Applicant: ABBOTT LAB

Inventor： DART MICHAEL J ,  CARROLL WILLIAM A ,  PATEL MEENA V ,  FROST JENNIFER M ,  PEDDI SRIDHAR ,  LATSHAW STEVEN P ,  KOLASA TEODOZYI ,  PEREZ-MEDRANO ARTURO ,  WANG XUEQING

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04

Abstract: La presente solicitud se refiere a compuestos que contienen tiazolilideno de la fórmula (I), en donde R1, R2, R3, R4, L2 y A son como se definen en la especificación. También se describen composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos utilizando tales compuestos y composiciones.

公开(公告)号：DE60036476T2

公开(公告)日：2008-06-12

申请号：DE60036476

申请日：2000-08-02

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BAI HAO ,  BRIONI JORGE D ,  CARROLL WILLIAM A ,  GOPALAKRISHNAN MURALI ,  GREGG ROBERT J ,  HOLLADAY MARK W ,  HUANG PEGGY P ,  KINCAID JOHN F ,  KORT MICHAEL E ,  KYM PHILIP R ,  LYNCH JOHN K ,  PEREZ-MEDRANO ARTURO ,  ZHANG HENRY Q

IPC: C07D213/74 ,  C07D249/18 ,  A61K31/166 ,  A61K31/17 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/47 ,  A61P1/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/10 ,  A61P17/14 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C275/54 ,  C07C279/22 ,  C07C279/28 ,  C07C279/30 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07C335/26 ,  C07D209/08 ,  C07D213/75 ,  C07D215/38 ,  C07D233/02 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12

公开(公告)号：AU2007266535A1

公开(公告)日：2007-12-06

申请号：AU2007266535

申请日：2007-05-30

Applicant: ABBOTT LAB

Inventor： NELSON DEREK W ,  LI TONGMEI ,  FROST JENNIFER M ,  RYTHER KEITH B ,  PEDDI SRIDHAR ,  TIETJE KARIN ROSEMARIE ,  PEREZ-MEDRANO ARTURO ,  KOLASA TEODOZYJ ,  GALLAGHER MEGAN E ,  PATEL MEENA V ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  DART MICHAEL J

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：CA2437405A1

公开(公告)日：2002-08-15

申请号：CA2437405

申请日：2002-01-17

Applicant: ABBOTT LAB

Inventor： HUANG PEGGY P ,  KINCAID JOHN F ,  ALTENBACH ROBERT J ,  BRIONI JORGE D ,  KYM PHILIP R ,  ZHANG HENRY Q ,  PEREZ-MEDRANO ARTURO ,  HOLLADAY MARK W ,  KORT MICHAEL E ,  LYNCH JOHN K ,  GREGG ROBERT J ,  BAI HAO ,  CARROLL WILLIAM A ,  GOPALAKRISHNAN MURALI

IPC: A61K31/17 ,  A61K31/275 ,  A61K31/4164 ,  A61K31/4406 ,  A61K31/455 ,  A61K31/47 ,  A61K31/505 ,  A61P1/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/06 ,  A61P15/10 ,  A61P17/00 ,  A61P17/14 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07C233/36 ,  C07C233/78 ,  C07C233/83 ,  C07C255/61 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07C335/20 ,  C07D209/08 ,  C07D209/30 ,  C07D213/40 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D215/38 ,  C07D233/42 ,  C07D233/84 ,  C07D235/06 ,  C07D239/42 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：BRPI0712720A2

公开(公告)日：2012-11-20

申请号：BRPI0712720

申请日：2007-05-30

Applicant: ABBOTT LAB

Inventor： DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMAIRE ,  KOLASA TEODOZYJ

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：PE20110804A1

公开(公告)日：2011-11-30

申请号：PE2011000626

申请日：2009-09-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE X4 ES O, S, S(O), N(Rbx); Rbx ES H, ALQUILO, -C(O)O(ALQUILO); A1 ES -(CR1aR1b)q1-A2, -(CR1aR1b)q1-G1c, ENTRE OTROS; R1a Y R1b SON CADA UNO H, HALOGENO, ALQUILO C1-C4, ALQUILO C1-C4, ENTRE OTROS q1 ES 1-4; G1c ES CICLOALQUENILO, HETEROCICLO, ARILO, HETEROARILO; A2 ES -CO, -SO2, ENTRE OTROS; A5 ES DE PREFERENCIA PIRAZOL, 1,3,4-TIADIAZOL, ENTRE OTROS; RX ES C1-C4 ALQUILO, HALOGENO, NO2, ENTRE OTROS; z ES 0-4. SON COMPUESTOS PREFERIDOS: N-{(3E)-5-TERT-BUTIL-1-METIL-2-[(2R)-TETRAHIDROFURAN-2-ILMETIL]-1,2-DIHIDRO-3H-PIRAZOL-3-ILIDEN}-2-[(2R)-TETRAHIDROFURAN-2-ILMETOXI]-5-(TRIFLUOROMETIL)BENZAMIDA; N-[(2Z)-3-BUTIL-5-TERT-BUTIL-1,3,4-TIADIAZOL-2(3H)-ILIDEN]-2-(2-HIDROXI-2-METILPROPOXI)-5-(TRIFLUOROMETIL)BENZAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE PRESENTA UN BIODISPONIBILIDAD ORAL MAYOR O IGUAL A 30%. DICHOS COMPUESTOS SON LIGANDOS DE RECEPTORES DE CANNABINOIDES UTIL EN EL TRATAMIENTO DEL DOLOR

公开(公告)号：CA2700049A1

公开(公告)日：2009-04-16

申请号：CA2700049

申请日：2008-10-08

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  PEREZ-MEDRANO ARTURO ,  DART MICHAEL J ,  NELSON DEREK W ,  KOLASA TEODOZY ,  FROST JENNIFER ,  LATSHAW STEVEN P ,  LI TONGMEI ,  LIU BO ,  PEDDI SRIDHAR ,  WANG XUEQING

IPC: C07D405/06 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/427 ,  A61K31/443 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.