公开(公告)号：DE2901180A1

公开(公告)日：1980-07-24

申请号：DE2901180

申请日：1979-01-13

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  LENKE DIETER PROF DR ,  WORSTMANN WOLFGANG DR MED

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：DE2835438A1

公开(公告)日：1980-03-06

申请号：DE2835438

申请日：1978-08-12

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: A61K31/40 ,  A61P9/00 ,  C07D207/32 ,  C07D207/333 ,  C07D405/12

Abstract: Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) (I) where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.

公开(公告)号：DE2727481A1

公开(公告)日：1979-01-11

申请号：DE2727481

申请日：1977-06-18

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LEHMANN HANS DIETER DR MED ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DE2527490A1

公开(公告)日：1976-12-30

申请号：DE2527490

申请日：1975-06-20

Applicant: BASF AG

Inventor： WEITZ HANS-MARTIN DIPL CHEM DR ,  FISCHER ROLF DIPL CHEM DR ,  LENKE DIETER PROF DR

IPC: C07D253/10 ,  C07D253/08

Abstract: New 1,2,4-dihydrotriazine-4-oxides and a new process for the manufacture of 1,2,4-dihydrotriazine-4-oxides by reaction of oximino-cycloalk-1-enes, which are substituted in the 1-position, with hydrazine and ketones. The compounds I are pesticides and starting materials for the manufacture of pesticides.

公开(公告)号：DE3373655D1

公开(公告)日：1987-10-22

申请号：DE3373655

申请日：1983-11-12

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JURGEN DR ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：AT29720T

公开(公告)日：1987-10-15

申请号：AT83111339

申请日：1983-11-12

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JUERGEN DR ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

公开(公告)号：DE3309595A1

公开(公告)日：1984-09-20

申请号：DE3309595

申请日：1983-03-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  GRIES JOSEF DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: C07D211/52 ,  A61K31/13 ,  A61K31/445 ,  A61K31/451 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C313/00 ,  C07C323/25 ,  C07D211/44 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07C93/14 ,  A61K31/485

Abstract: Compounds of the general formula I where R1, R2, R3, R4 and n have the meanings given in the description, are useful for treating cardiac disorders.

公开(公告)号：DE3124699A1

公开(公告)日：1983-01-13

申请号：DE3124699

申请日：1981-06-24

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DIPL CHEM DR ,  THYES MARCO DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  KOENIG HORST PROF DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  A61K31/40 ,  A61K31/47 ,  C07D401/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：DE3101456A1

公开(公告)日：1982-09-02

申请号：DE3101456

申请日：1981-01-19

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  STEINER GERD DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P9/02 ,  A61P11/08 ,  A61P25/08 ,  A61P25/20 ,  C07D231/12 ,  C07D231/38 ,  C07D233/60 ,  C07D233/88 ,  C07D239/42 ,  C07D261/08 ,  C07D295/06 ,  C07D295/092 ,  C07D521/00 ,  C07D403/12 ,  C07D403/10 ,  C07D413/12 ,  C07D413/10

Abstract: Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula I where R1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.

公开(公告)号：DE3006809A1

公开(公告)日：1981-09-24

申请号：DE3006809

申请日：1980-02-23

Applicant: BASF AG

Inventor： SCHLECKER RAINER DIPL CHEM DR ,  FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D261/10 ,  C07D261/18 ,  C07F9/653 ,  C07D261/06