Patent search ap:("BASF AG") AND inv:"RASCHACK MANFRED DR" Page 4

31.

发明专利
Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors 未知

公开(公告)号：DE19738578A1

公开(公告)日：1999-03-11

申请号：DE19738578

申请日：1997-09-04

Applicant: BASF AG

Inventor： AMBERG WILHELM DR , JANSEN ROLF DR , KLINGE DAGMAR DR , RIECHERS HARTMUT DR , HERGENROEDER STEFAN DR , RASCHACK MANFRED DR , UNGER LILIANE DR

IPC: C07D239/34 , C07D239/52 , C07D277/34 , C07D409/12 , C07D491/052 , C07D239/24 , A61K31/215 , A61K31/41 , A61K31/495 , C07C59/64 , C07C69/734 , C07D233/32 , C07D239/80 , C07D239/96 , C07D263/22

Abstract: Carboxylic acid derivatives (I) and their salts and enantiomers are new. Carboxylic acid derivatives of formula (I) and their salts and enantiomers are new. R = tetrazole or COR1; R1 = OR7, 3-8C cycloalkyl, 1-8C alkyl, optionally substituted phenyl or benzyl, 3-6C alkenyl or optionally substituted 3-6C alkynyl; R7 = H, alkali or alkaline earth metal cation or organic ammonium ion; R2, R3 = H, OH, NH2, mono- or di(1-4C alkyl)amino, halo, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy or 1-4C alkylthio; or CR2+CR10 = 5-6-membered ring; X, Y = N or CH; W = N or CR10; R10 = H or 1-4C alkyl; or CR10+CR2 or CR10+CR3 = 5-6-membered alkylene or alkenylene ring (optionally substituted and in which one or more of the methylene groups may be replaced by O, S, NH or N-(1-4C alkyl)); R4, R5 = optionally substituted phenyl or naphthyl (bound via a direct bond, methylene, ethylene, ethenylene, O, S, SO2, NH or N-alkyl) or optionally substituted 3-8C cycloalkyl; R6 = 3-8C cycloalkyl, phenyl, naphthyl or 5-6-membered heteroaromatic group containing 1-3 N atoms and/or an S or O atom (all optionally substituted); Z = O or S; B = 2-4C alkylene; Het = heterocyclic group of formula (i) or (ii); T = O, S or NR8; and R8 = 1-6C alkyl.

32.

发明专利
NOVEL AMINO ACID DERIVATIVES, THEIR PREPARATION AND USE 未知

公开(公告)号：CZ104598A3

公开(公告)日：1998-09-16

申请号：CZ104598

申请日：1996-09-26

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR , AMBERG WILHELM DR , KLING ANDREAS DR , RIECHERS HARTMUT DR , UNGER LILIANE DR , RASCHACK MANFRED DR

IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D239/70 , C07D487/02 , C07D251/42

Abstract: The invention relates to amino acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to the use thereof as drugs.

33.

发明专利
CARBOXYLIC ACID DERIVATIVE 未知

公开(公告)号：CZ113297A3

公开(公告)日：1998-03-18

申请号：CZ113297

申请日：1995-10-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR , KLINGE DAGMAR DR , AMBERG WILHELM DR , KLING ANDREAS DR , MULLER STEFAN DR , BAUMANN ERNST DR , RHEINHEIMER JOACHIM DR , VOGELBACHER JOSEF UWE DR , WERNET WOLFGANG DR , UNGER LILIANE DR , RASCHACK MANFRED DR

IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , A61K31/495

Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.

34.

发明专利
未知

公开(公告)号：DE19536891A1

公开(公告)日：1997-04-10

申请号：DE19536891

申请日：1995-10-04

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR , AMBERG WILHELM DR , KLING ANDREAS DR , RIECHERS HARTMUT DR , UNGER LILIANE DR , RASCHACK MANFRED DR

IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D251/12 , C07D405/06 , C07D403/06 , C07D491/044 , C07C229/02 , A61K31/495

Abstract: The invention relates to amino acid derivatives of formula (I), in which the groups have the meaning given in the description. It also relates to the use thereof as inhibitors for endothelin receptors.

35.

发明专利
未知

公开(公告)号：DE4341666A1

公开(公告)日：1995-06-08

申请号：DE4341666

申请日：1993-12-07

Applicant: BASF AG

Inventor： ALBRECHT HANS-PETER DR , BOEHM HANS-JOACHIM DR , RASCHACK MANFRED DR , UNGER LILIANE DR , WERNET WOLFGANG DR

IPC: C07C62/06 , C07C62/18 , C07C62/38 , C07C69/757 , C07C205/56 , C07C229/46 , C07C229/50 , C07C235/34 , C07D209/18 , C07C69/753 , C07C205/11 , C07C245/24 , C07D213/74

36.

发明专利
未知

公开(公告)号：AT113028T

公开(公告)日：1994-11-15

申请号：AT89113379

申请日：1989-07-21

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR , RASCHACK MANFRED DR , VON PHILIPSBORN GERDA DR

IPC: A61K31/135 , A61K31/13 , A61K31/395 , A61K31/40 , A61K31/445 , A61P9/06 , C07C217/22 , C07D295/08 , C07D295/092

Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.