公开(公告)号：ZA8505224B

公开(公告)日：1986-03-26

申请号：ZA8505224

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D ,  A61K

CPC classification number: C07D403/04 ,  C07D403/10

公开(公告)号：NO852793A

公开(公告)日：1986-01-13

申请号：NO852793

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D

CPC classification number: C07D403/04 ,  C07D403/10

公开(公告)号：CA2067224C

公开(公告)日：2001-02-13

申请号：CA2067224

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K17/06

Abstract: Hirudin/polyalkylene glycol derivatives of the formula (A-(CH2)n-¢O-(CH2)n!m-B-!p Hir ¢sic! I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：NO983677D0

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C12N

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：HRP970077A2

公开(公告)日：1998-04-30

申请号：HRP970077

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：LV5809B4

公开(公告)日：1997-04-20

申请号：LV960306

申请日：1996-07-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/58 ,  A61K47/48 ,  C07K14/815 ,  C07K17/08

公开(公告)号：AT135374T

公开(公告)日：1996-03-15

申请号：AT91900751

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS WOLFGANG

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: PCT No. PCT/EP90/01998 Sec. 371 Date May 29, 1992 Sec. 102(e) Date May 29, 1992 PCT Filed Nov. 22, 1990 PCT Pub. No. WO91/08229 PCT Pub. Date Jun. 13, 1991Hirudin/polyalkylene glycol derivatives of the formula[A-(CH2)n-[O-(CH2)nlm-B-]p Hir [sic]I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：CA1332224C

公开(公告)日：1994-10-04

申请号：CA590612

申请日：1989-02-09

Applicant: BASF AG

Inventor： ESCHENFELDER VOLKER ,  SCHMIED BERNHARD ,  RUEBSAMEN KLAUS

IPC: A61K38/16 ,  A61K38/49 ,  A61K38/54 ,  A61K38/58 ,  A61K45/06 ,  A61K37/64 ,  A61K37/54

Abstract: A mixture of a substance having thrombolytic activity and of an antithrombotic substance which is suitable for controlling vascular disorders caused by thrombosis is described.

公开(公告)号：ES2011242B3

公开(公告)日：1990-01-01

申请号：ES86116409

申请日：1986-11-26

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00

公开(公告)号：DK317285A

公开(公告)日：1986-01-13

申请号：DK317285

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.