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    1-(3-(3,4,5-TRIMETHOXYPHENOXY)-2-HYDROXYPROPYL)-4-ARYL PIPERAZINE DERIVATIVES
    31.
    发明专利
    1-(3-(3,4,5-TRIMETHOXYPHENOXY)-2-HYDROXYPROPYL)-4-ARYL PIPERAZINE DERIVATIVES 未知

    公开(公告)号：CA1124718A

    公开(公告)日：1982-06-01

    申请号：CA300288

    申请日：1978-04-03

    Applicant: DEGUSSA

    Inventor： KLEEMANN AXEL ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS ,  ENGEL JURGEN

    IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  C07D213/74 ,  C07D213/80 ,  C07D295/033 ,  C07D295/088 ,  C07D295/092 ,  C07D295/135 ,  C07D303/24 ,  C07D307/68 ,  C07D333/38 ,  C07D401/00

    Abstract: The present invention provides 1-3-(3,4,5-trimethoxy-phenoxy)-2-hydroxypropyl!-4-aryl piperazine derivatives. The derivatives have the formula in which R1 in a hydrogen atom, a C2 to C6-alkanoyl radical, 3,4,5-trimethoxy benzoyl radical, a nicotinoyl radical or a thienyl carbonyl radical and R2 represents a phenyl, naphthyl or pyridyl radical which may be substituted by the radicals R3 and R4, the radicals R3 and R4, which may be the same or different, each representing hydrogen, hydroxyl, fluorine, chlorine, bromine, a nitro group, a trifluoromethyl group, a C1 to C6-alkyl radical, a C1 to C6-alkoxy radical, a C1 to C6alkyl thio radical, a C2 to C6-alkanoyl radical, an amino group, a C2-C6-alkanoyl-amino group, a C2-C6-alkanoyl-oxy group, a benzoyl-oxy group, a cyclohexyl-carbonyl-oxy group or a thienylcarbonyl-oxy group, pharmaceutically acceptable, and to salts of their compounds. The compounds are pharmacodynamically active and show, for example, a pronounced anti-aggressive action together with neuroleptic properties, anti-convulsive and hypnotic effects being in evidence to a very limited extent only, if at all. In addition, the compounds show fever-reducing and oedemainhibiting effects.

    DITHIENYL ALKYL AMINES AND PROCESS FOR THEIR PRODUCTION
    35.
    发明专利
    DITHIENYL ALKYL AMINES AND PROCESS FOR THEIR PRODUCTION 未知

    公开(公告)号：CA1096380A

    公开(公告)日：1981-02-24

    申请号：CA294846

    申请日：1978-01-12

    Applicant: DEGUSSA

    Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

    IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/14

    Abstract: The present invention provides compounds of the general formula I wherein has either the structure or the structure , Alk represents a straight or branched C1-C5-alkylene group and Y a C3-C7-cycloalkyl radical, a methylenedioxy-benzyl radical, a benzyl radical which is singly, doubly or triply substituted by C1-C4-alkoxy groups, or it represents a straight or branched C1-C6-alkyl radical substituted by a di-C1-C4-alkyl-amino group, a morpholino group, or it represents the radical wherein R represents a C1-C4-alkyl group and the hydroxyl group can also be acylated by a C2-C6-alkanoyl group or wherein the group -NHY represents the radical and R' represents a phenyl radical, a phenyl radical, which is Aingly or doubly substituted by C1-C4-alkyl groups, C1-C4 alkoxy groups or halogen atoms, a C1-C6-alkyl radical, a C1-C4-oxy-alkyl radical or a phenyl-C1-C4-alkyl radical, which can also be substituted in the phenyl ring by 1 to 3 C1-C4-alkoxy groups or the radical -NH-CH(R)-CH(OH)-C6H5 (wherein R has the meaning defined above) when Alk consists of 2 to 5 carbon atoms or a pharmaceutically acceptable salt thereof. These compounds are pharmaceutically effective, particularly in the case of heart and circulation disorders. In particular, they cause an increase of the peripheral and cerebral blood flow.

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