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公开(公告)号：AU2017336156A1
公开(公告)日：2019-05-02
申请号：AU2017336156
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compounds of Formula (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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32.发明专利
公开(公告)号：JOP20190125A1
公开(公告)日：2017-06-16
申请号：JOP20190125
申请日：2019-05-28
Applicant: VERTEX PHARMA
Inventor： ZHOU JINGLAN , VAN GOOR FREDRICK F , HADIDA RUAH SARA SABINA , SIESEL DAVID ANDREW , CLEVELAND THOMAS , GULEVICH ANTON , PIERRE FABRICE JEAN DENIS , STAVROPOULOS KATHY , GROOTENHUIS PETER DIEDERIK JAN , KANG PING , YOUNG TOMOTHY JOHN , ANDERSON COREY , ALCACIO TIMOTHY , KESHAVARZ-SHOKRI ALI , MCCARTNEY JASON , ANGELL PAUL TIMOTHY , GROSS RAYMOND STANLEY , MILLER MARK THOMAS , HUGHES ROBERT M , ABELA ALEXANDER RUSSELL , JOSHI PRAMOD VIRUPAX , SHI YI , CLEMENS JEREMY J , UY JOHNNY , BAEK MINSON , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , TERMIN ANDREAS P , SHRESTHA MUNA , FERRIS LORI ANN , HSIA CLARA KUANG-JU , PARASELLI PRASUNA
Abstract: يتمالكشفعنمركباتلهاالصيغة ( I )، أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،وطرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها. كمايتمالكشفعنصورفيالحالةالصلبةللمركب 1 وأملاحوذواباتمنه.
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公开(公告)号：MX388103B
公开(公告)日：2025-03-19
申请号：MX2019006637
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , KESHAVARZ-SHOKRI ALI , TERMIN ANDREAS P , GULEVICH ANTON , HSIA CLARA KUANG-JU , ANDERSON COREY , SIESEL DAVID ANDREW , PIERRE FABRICE JEAN DENIS , VAN GOOR FREDRICK F , KHATUYA HARIPADA , MCCARTNEY JASON , CLEMENS JEREMY J , ZHOU JINGLAN , UY JOHNNY , STAVROPOULOS KATHY , FERRIS LORI ANN , MILLER MARK THOMAS , BAEK MINSON , SHRESTHA MUNA , KRENITSKY PAUL JHON , ANGELL PAUL TIMOTHY , GROOTENHUIS PETER DIEDIERIK JAN , KANG PING , JOSHI PRAMOD VIRUPAX , PARASELLI PRASUNA , GROSS RAYMOND STANLEY , HUGHES ROBERT M , HADIDA RUAH SARA SABINA , CLEVELAND THOMAS , ALCACIO TIMOTHY , YOUNG TOMOTHY JOHN , SHI YI
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Se describen compuestos de Fórmula (I): (ver fórmulas) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los anteriores y metabolitos de cualquiera de los anteriores. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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公开(公告)号：HRP20211683T1
公开(公告)日：2022-03-04
申请号：HRP20211683
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：MD3519401T2
公开(公告)日：2022-02-28
申请号：MDE20190875
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compuşii cu Formula I:sărurile acceptabile farmaceutic ale acestora, derivaţii deuteraţi ai oricărora dintre cei anteriori, şi metaboliţii oricărora dintre cei anteriori sunt divulgaţi. Compoziţiile farmaceutice care-i cuprind pe aceştia, metodele de tratare a fibrozei chistice utilizȃndu-i pe aceştia, şi metodele pentru fabricarea acestora sunt de asemenea divulgate.
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Patent Agency Ranking
公开(公告)号：SI3519401T1
公开(公告)日：2022-01-31
申请号：SI201731014
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D471/00 , C07D498/00
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公开(公告)号：PL3519401T3
公开(公告)日：2022-01-31
申请号：PL17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：DK3519401T3
公开(公告)日：2021-11-22
申请号：DK17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：AU2021211993A1
公开(公告)日：2021-08-26
申请号：AU2021211993
申请日：2021-08-03
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOND VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Abstract Compounds of Formula (I): )S 0 0 x y 1 N (R), R1 (R3 (R4)(, pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：MA49235B1
公开(公告)日：2021-02-26
申请号：MA49235
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： FERRIS LORI , ANDERSON COREY , CLEVELAND THOMAS , KHATUYA HARIPADA , MCCARTNEY JASON , UY JOHNNY , ZHOU JINGLAN , ALCACIO TIMOTHY , BAEK MINSON , HADIDA RUAH SARA , HUGHES ROBERT , KESHAVARZ-SHOKRI ALI , MILLER MARK , JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , ABELA ALEXANDER , PARASELLI PRASUNA , SIESEL DAVID , ANGELL PAUL , CLEMENS JEREMY , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HSIA CLARA , KANG PING , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , STAVROPOULOS KATHY , VAN GOOR FREDRICK , YOUNG TOMOTHY
IPC: A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04 , C07D401/14
Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.
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