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公开(公告)号：MX388103B
公开(公告)日：2025-03-19
申请号：MX2019006637
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , KESHAVARZ-SHOKRI ALI , TERMIN ANDREAS P , GULEVICH ANTON , HSIA CLARA KUANG-JU , ANDERSON COREY , SIESEL DAVID ANDREW , PIERRE FABRICE JEAN DENIS , VAN GOOR FREDRICK F , KHATUYA HARIPADA , MCCARTNEY JASON , CLEMENS JEREMY J , ZHOU JINGLAN , UY JOHNNY , STAVROPOULOS KATHY , FERRIS LORI ANN , MILLER MARK THOMAS , BAEK MINSON , SHRESTHA MUNA , KRENITSKY PAUL JHON , ANGELL PAUL TIMOTHY , GROOTENHUIS PETER DIEDIERIK JAN , KANG PING , JOSHI PRAMOD VIRUPAX , PARASELLI PRASUNA , GROSS RAYMOND STANLEY , HUGHES ROBERT M , HADIDA RUAH SARA SABINA , CLEVELAND THOMAS , ALCACIO TIMOTHY , YOUNG TOMOTHY JOHN , SHI YI
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Se describen compuestos de Fórmula (I): (ver fórmulas) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los anteriores y metabolitos de cualquiera de los anteriores. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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公开(公告)号：AU2018309043B2
公开(公告)日：2022-03-31
申请号：AU2018309043
申请日：2018-08-02
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL T , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , NUGENT WILLIAM A , SMITH DAVID , STUDLEY JOHN , HUGHES ROBERT M
IPC: C07D207/06 , C07D207/263
Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
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公开(公告)号：HRP20211683T1
公开(公告)日：2022-03-04
申请号：HRP20211683
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：MD3519401T2
公开(公告)日：2022-02-28
申请号：MDE20190875
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compuşii cu Formula I:sărurile acceptabile farmaceutic ale acestora, derivaţii deuteraţi ai oricărora dintre cei anteriori, şi metaboliţii oricărora dintre cei anteriori sunt divulgaţi. Compoziţiile farmaceutice care-i cuprind pe aceştia, metodele de tratare a fibrozei chistice utilizȃndu-i pe aceştia, şi metodele pentru fabricarea acestora sunt de asemenea divulgate.
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公开(公告)号：SI3519401T1
公开(公告)日：2022-01-31
申请号：SI201731014
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D471/00 , C07D498/00
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Patent Agency Ranking
公开(公告)号：PL3519401T3
公开(公告)日：2022-01-31
申请号：PL17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：DK3519401T3
公开(公告)日：2021-11-22
申请号：DK17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：AU2021211993A1
公开(公告)日：2021-08-26
申请号：AU2021211993
申请日：2021-08-03
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOND VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Abstract Compounds of Formula (I): )S 0 0 x y 1 N (R), R1 (R3 (R4)(, pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：DK3551622T3
公开(公告)日：2020-11-23
申请号：DK17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：AU2018309043A1
公开(公告)日：2020-02-27
申请号：AU2018309043
申请日：2018-08-02
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL T , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , NUGENT WILLIAM A , SMITH DAVID , STUDLEY JOHN , HUGHES ROBERT M
IPC: C07D207/06 , C07D207/263
Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
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