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公开(公告)号：KR1020070109394A
公开(公告)日：2007-11-15
申请号：KR1020060042278
申请日：2006-05-11
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K31/708 , A61K31/7076 , A61P1/00
CPC classification number: A61K31/708 , Y10S514/886
Abstract: A composition comprising 8-oxo-deoxyguanosine is provided to show equal effect to that of mesalazine, a conventional representative anti-inflammatory agent, without side effects such as hypersensitivity, nausea, vomiting and headache, thereby being used for patients showing hypersensitivity on salicylic acid and a derivative thereof and being usefully used as an anti-inflammatory agent for treating colitis. A pharmaceutical composition for treating colitis such as infectious colitis, ulcerative colitis and Crohn's disease comprises 8-oxo-deoxyguanosine(8-oxo-dG) or 8-hydroxydeoxyguanosine(8-oh-dG) as an effective ingredient. The composition further comprises at least one pharmaceutically acceptable carrier selected from the group consisting of saline solution, sterile water, Ringer's solution, buffered saline solution, albumin injection solution, dextrose solution, malto-dextrin solution and ethanol.
Abstract translation: 提供了包含8-氧代 - 脱氧鸟苷的组合物，以显示与美沙拉嗪（常规的代表性抗炎剂）相同的效果，没有副作用，例如超敏反应，恶心，呕吐和头痛，因此用于对水杨酸显示超敏反应的患者 及其衍生物，可用作治疗结肠炎的抗炎剂。 用于治疗结肠炎如感染性结肠炎，溃疡性结肠炎和克罗恩病的药物组合物包含8-氧代 - 脱氧鸟苷（8-氧代-dG）或8-羟基脱氧鸟苷（8-oh-dG）作为有效成分。 组合物还包含至少一种药学上可接受的载体，其选自盐溶液，无菌水，林格氏溶液，缓冲盐溶液，白蛋白注射溶液，葡萄糖溶液，麦芽糊精溶液和乙醇。
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公开(公告)号：KR1020070109099A
公开(公告)日：2007-11-15
申请号：KR1020060041610
申请日：2006-05-09
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01N33/5308 , A01N43/76 , C07D263/58 , C07K16/44
Abstract: A conjugate of a hapten compound of metamifop and a protein is provided to be used as an antibody for rapidly and quantitatively detecting the metamifop. A conjugate is characterized in that a hapten compound of metamifop is bound to a protein by an amide bond. The hapten compound of the metamifop is represented by the formula(1), wherein each R1, R2, R3, and R4 is independently H, carboxyl, hydroxy, C1-10 alkyl, halogen, cyano, amino, thiol, aldehyde, nitro, C2-10 carboxyalkyl or C1-10 hydroxyalkyl; each R5 and R6 is independently H, carboxyl, hydroxy, C1-10 alkyl, halogen, cyano, amino, thiol, aldehyde, nitro, C1-10 carboxyalkyl, C1-10 hydroxyalkyl or a group represented by the structural formula(1-a); R7 is H, C2-10 carboxyalkyl or C1-10 alkyl; and each R8, R9, R10, R11 and R12 is independently H, carboxyl, hydroxy, C1-10 alkyl, halogen, amino, thiol, aldehyde, C2-10 carboxyalkyl or C1-10 hydroxyalkyl, provided that at least one of the R1 to R12 is at least one of carboxyl and amino. The protein is bovine serum albumine(BSA), human serum albumine(HSA), fibrinogen, ovalbumin, thyroglobulin or keyhole limpet hemocyanin(KLH). An antibody is produced by being reacted to the conjugate and is specifically bound to the metamifop. A method for producing the antibody comprises the steps of: (a) immunizing mammals with the conjugate; and (b) selecting the antibody specific to the metamifop from the mammals.
Abstract translation: 提供metamifop和蛋白质的半抗原化合物的缀合物用作快速和定量检测metamifop的抗体。 缀合物的特征在于，metamifop的半抗原化合物通过酰胺键与蛋白质结合。 metamifop的半抗原化合物由式（1）表示，其中每个R 1，R 2，R 3和R 4独立地为H，羧基，羟基，C 1-10烷基，卤素，氰基，氨基，硫醇，醛，硝基， C2-10羧基烷基或C1-10羟烷基; 每个R 5和R 6独立地是H，羧基，羟基，C 1-10烷基，卤素，氰基，氨基，硫醇，醛，硝基，C 1-10羧基烷基，C 1-10羟烷基或由结构式 ）; R7是H，C2-10羧基烷基或C1-10烷基; 并且每个R 8，R 9，R 10，R 11和R 12独立地为H，羧基，羟基，C 1-10烷基，卤素，氨基，硫醇，醛，C 2-10羧基烷基或C 1-10羟烷基，条件是R1 至R12是羧基和氨基中的至少一个。 蛋白质是牛血清白蛋白（BSA），人血清白蛋白（HSA），纤维蛋白原，卵清蛋白，甲状腺球蛋白或钥孔血蓝蛋白（KLH）。 通过与缀合物反应产生抗体，并且特异性地结合到metamifop。 制备抗体的方法包括以下步骤：（a）用该缀合物免疫哺乳动物; 和（b）从哺乳动物中选择特异性抗体的抗体。
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公开(公告)号：KR1020070109098A
公开(公告)日：2007-11-15
申请号：KR1020060041609
申请日：2006-05-09
Applicant: 재단법인서울대학교산학협력재단
Abstract: A method for detecting metamifop is provided to detect the metamifop rapidly and quantitatively using an antibody against a complex in which a specific hapten compound of the metamifop and protein are bound. A method for detecting metamifop in a sample comprises the steps of: (a) contacting an antibody generated from a complex in which hapten compound of metamifop and protein are bound by an amide bond with the sample including metamifop and a complex in which a hapten compound of metamifop fixed on a solid support and protein are bound by an amide bond; and (b) detecting the binding of the antibody regarding the metamifop using an enzyme labeled secondary antibody, wherein the hapten compound of the metamifop includes a carboxyl or an amino group, the protein is bovine serum albumine(BSA), human serum albumine(HSA), fibrinogen, ovalbumin, thyroglobulin or keyhole limpet hemocyanin(KLH).
Abstract translation: 提供了一种检测metamifop的方法，用于快速和定量地使用针对结合有metamifop和蛋白质的特定半抗原化合物的复合物的抗体来检测metamifop。 一种用于检测样品中metamifop的方法包括以下步骤：（a）使由复合物产生的抗体接触，其中metamifop和蛋白质的半抗原化合物通过酰胺键与包含metamifop的样品和其中半抗原化合物 固定在固体支持物和蛋白质上的metamifop被酰胺键结合; （b）使用酶标记的二抗检测抗体与metamifop的结合，其中metamifop的半抗原化合物包括羧基或氨基，所述蛋白是牛血清白蛋白（BSA），人血清白蛋白（HSA ），纤维蛋白原，卵清蛋白，甲状腺球蛋白或钥孔血蓝蛋白（KLH）。
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公开(公告)号：KR100775529B1
公开(公告)日：2007-11-15
申请号：KR1020050106098
申请日：2005-11-07
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61B10/0233 , A61B10/04 , A61B10/06
Abstract: 본 발명은 생체 내부에 존재하는 병변 세포 조직의 표본을 채취하는 데에 사용하는 카테터(Catheter)에 관한 것으로서, 특히, 마이크로 생체검사 도구(micro biopsy tools)를 자유롭게 결합하거나 분리할 수 있고, 조직 채취 시 병변부위에 생체검사 도구를 삽입하였다가 빼내는 간단한 조작만으로 검사에 필요한 조직을 채취할 수 있도록 구성된 카테터에 관한 것이다.
본 발명에 의한 카테터는, 최소 침습으로 수검자의 진단과 치료에 필요한 조직을 채취하는 것이 가능하고, 이에 따라 조직 채취에 있어서 수검자의 고통을 경감시키며 채취부위에 천공이 발생하는 것을 방지할 수 있다. 또한, 본 발명의 카테터는 생체검사 도구를 용이하게 착탈시킬 수 있으므로, 생체검사 도구만을 계속 교체해 가면서 반영구적으로 사용할 수 있다.
카테터, 조직채취, 생체검사, 최소 침습-
公开(公告)号：KR1020070108297A
公开(公告)日：2007-11-09
申请号：KR1020060040787
申请日：2006-05-06
Applicant: 삼성전자주식회사 , 재단법인서울대학교산학협력재단
IPC: H04B7/26
CPC classification number: H04W72/087 , H04W72/1226
Abstract: An apparatus and a method for employing resources in a mobile communication system are provided to change non-real time type segment resources into real time type segment resources, thereby satisfying request bandwidth of real time connection using low resources and reducing the computation quantity. A method for employing resources in a mobile communication system comprises the following steps of: classifying whole frequency band into multiple segment types which are consisted of time and frequency areas by considering a service quality level requested by a mobile station and a channel state between the mobile station and a base station; determining a segment type corresponded to data to be transmitted when data to be transmitted is generated; allocating real time type segment when the data to be transmitted is transmitted in a real time; and allocating remaining real time type segment as a non-real time transmission data.
Abstract translation: 提供一种在移动通信系统中采用资源的装置和方法，将非实时类型的分段资源改变为实时类型的分段资源，从而满足使用低资源的实时连接的请求带宽，并减少计算量。 一种在移动通信系统中采用资源的方法包括以下步骤：通过考虑由移动台请求的服务质量等级将整个频带分类为由时间和频率区域组成的多个片段类型，以及移动台之间的信道状态 车站和基站; 当生成要发送的数据时，确定对应于要发送的数据的段类型; 当要发送的数据实时发送时分配实时类型段; 并将剩余实时类型段分配为非实时传输数据。
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Patent Agency Ranking
公开(公告)号：KR1020070108062A
公开(公告)日：2007-11-08
申请号：KR1020070042611
申请日：2007-05-02
Applicant: 재단법인서울대학교산학협력재단 , 주프로스테믹스
IPC: C08B37/08
CPC classification number: C08B37/0072 , A61K35/30 , A61K35/32 , A61K35/34 , A61K35/545 , C08J9/28 , C08J2201/026 , C08J2201/0484 , C08J2205/022 , C08J2305/08 , C12N5/0068 , C12N2533/80 , C12N2537/00 , C12N2537/10
Abstract: A method for preparing a porous hyaluronic acid sponge for a cell delivery system is provided to produce a porous hyaluronic acid sponge capable of controlling pore size thereof so as to cultivate cells well. A method for preparing a porous hyaluronic acid sponge includes the steps of: (S101) dissolving a hyaluronic acid in an aqueous sodium hydroxide solution; (S102) adding an epoxy-based crosslinking agent to the aqueous sodium hydroxide solution containing hyaluronic acid, and then homogenizing the obtained hyaluronic acid solution; (S103) hydrogelling the homogenized hyaluronic acid solution; (S104) washing the hyaluronic acid hydrogel with ultrapure water; (S105) swelling the washed hyaluronic acid hydrogel to acquire porosity; and (S106) freeze-drying the hyaluronic acid hydrogel to obtain a porous hyaluronic acid sponge.
Abstract translation: 提供了一种制备用于细胞递送系统的多孔透明质酸海绵的方法，以制备能够控制其孔径以便良好培养细胞的多孔透明质酸海绵。 制备多孔透明质酸海绵的方法包括以下步骤：（S101）将透明质酸溶解在氢氧化钠水溶液中; （S102）向含有透明质酸的氢氧化钠水溶液中添加环氧类交联剂，然后均化所得透明质酸溶液; （S103）使匀化的透明质酸溶液水凝; （S104）用超纯水洗涤透明质酸水凝胶; （S105）溶解洗涤后的透明质酸水凝胶以获得孔隙度; 和（S106）冷冻干燥透明质酸水凝胶，得到多孔透明质酸海绵。
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公开(公告)号：KR100773134B1
公开(公告)日：2007-11-02
申请号：KR1020060119438
申请日：2006-11-30
Applicant: 재단법인서울대학교산학협력재단
IPC: C01G23/047 , C01G23/04 , B82B3/00
CPC classification number: C01G23/047 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2006/14 , C01P2006/16 , C01P2006/17
Abstract: A method for preparing porous titanium dioxide using cyclodextrin is provided to produce titanium dioxide having a uniform pore size and a large specific surface area, facilitate the control of pore size, and be a simple process without requiring a separate sintering process. A method for preparing porous titanium dioxide using cyclodextrin includes the steps of: (S1) preparing a cyclodextrin or cyclodextrin derivative, and a titanium precursor; and (S2) reacting the cyclodextrin or cyclodextrin derivative with the titanium precursor in an aqueous solution of sulfuric acid. The step(S2) is carried out in the presence of a reaction inhibitor for controlling a polymerization rate of the titanium precursor. A molar ratio of the cyclodextrin to the titanium precursor is 1:0.5-1:12.
Abstract translation: 提供了使用环糊精制备多孔二氧化钛的方法，以制备具有均匀孔径和大比表面积的二氧化钛，有助于控制孔径，并且是简单的工艺，不需要单独的烧结工艺。 使用环糊精制备多孔二氧化钛的方法包括以下步骤：（S1）制备环糊精或环糊精衍生物和钛前体; 和（S2）使环糊精或环糊精衍生物与钛前体在硫酸水溶液中反应。 步骤（S2）在用于控制钛前体的聚合速率的反应抑制剂的存在下进行。 环糊精与钛前体的摩尔比为1:0.5-1:12。
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公开(公告)号：KR1020070106220A
公开(公告)日：2007-11-01
申请号：KR1020060038839
申请日：2006-04-28
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K31/4164 , A61K31/4745 , A61K31/496 , A61K31/4965 , A61K31/702 , A61K33/24 , A61K2300/00 , A61Q11/00 , G01N33/5008 , Y10S514/8995
Abstract: Compositions for treatment of tooth pain containing TRP(transient receptor potential) channel blockers are provided to treat tooth pain caused by temperature stimulation by blocking the TRP channel which is activated at a specific temperature in mammals. A composition for treatment of tooth pain contains a TRP channel blocker selected from capsazepine and ruthenium red, wherein the TRP is TRPV1, TRPM8 or TRPA1 and the composition is formulated as toothpaste, mouthwash, good or chewing gum. A screening method of the TRP channel blocker comprises the steps of: (a) culturing a cell expressing TRP; (b) contacting a candidate material with the cultured cell; and (c) measuring the reduction of Ca^2+ ion concentration in a first afferent neuron cell of tooth by inhibition of thermo-TRP channel activation.
Abstract translation: 用于治疗含有TRP（瞬时受体电位）通道阻滞剂的牙痛的组合物用于治疗由温度刺激引起的牙痛，通过阻断在哺乳动物中在特定温度下被激活的TRP通道。 用于治疗牙痛的组合物含有选自辣椒碱和钌红的TRP通道阻断剂，其中TRP为TRPV1，TRPM8或TRPA1，组合物配制成牙膏，漱口剂，良好或口香糖。 TRP通道阻断剂的筛选方法包括以下步骤：（a）培养表达TRP的细胞; （b）将候选材料与培养的细胞接触; 和（c）通过抑制热TRP通道活化来测量牙齿的第一传入神经元细胞中Ca 2+离子浓度的降低。
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公开(公告)号：KR100772078B1
公开(公告)日：2007-10-31
申请号：KR1020060109667
申请日：2006-11-07
Applicant: 한국기초과학지원연구원 , 재단법인서울대학교산학협력재단
IPC: C07H1/06
Abstract: Novel monogalactosyldiacylglycerol compounds isolated from Sargassum Thunbergii are provided which shows anti-fungal activity on Candida albican and contains both alpha-linoleic acid and eicosapentaenoic acid(EPA). A [(2S)-1-O-(5Z,8Z,11Z,14Z,17Z -eicosapentaenoyl)-2-O-(9Z,12Z,15Z-octadecatrienoyl)-3-O-beta-Dgalactopyranosyl-sn-glycerol] is represented by the formula(1). A (2S)-1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-beta-D-galactopyranosyl-sn-glycerol is represented by the formula(2). A method for preparing the monogalactosyldiacylglycerol compound comprises the steps of: (a) after mixing cut Sargassum Thunbergii with methanol in a weight ratio of 1:1-1:3 and leaving it for 48-72 hours, filtering it; (b) concentrating the methanol filtrate under reduced pressure and adding a mixture solution of butanol and water in a weight ratio of 1:1 thereto; (c) concentrating solvent of the butanol layer under reduced pressure and adding a mixture solution consisting of methanol and water in a weight ratio of 15:85 and normal hexane thereto; and (d) concentrating solvent of the methanol layer under reduced pressure and isolating the desired product through a reverse silica flash chromatography.
Abstract translation: 提供了从马齿苋（Thargarum Thunbergii）分离的新型单糖半乳糖二甘油化合物，其显示白念珠菌（Candida albican）的抗真菌活性，并含有α-亚油酸和二十碳五烯酸（EPA）。 A [（2S）-1-O-（5Z，8Z，11Z，14Z，17Z-二十碳烯酰基）-2-O-（9Z，12Z，15Z-十八碳三烯酰基）-3-O-β-D-吡喃半乳糖基-sn-甘油] 由式（1）表示。 代表了（2S）-1-O-（9Z，12Z，15Z-十八碳三烯酰基）-2-O-（6Z，9Z，12Z，15Z-十八碳四烯酰基）-3-O-β-D-吡喃半乳糖基-sn-甘油 通过式（2）。 制备单半乳糖基二酰基甘油化合物的方法包括以下步骤：（a）将切碎的马鞭草皂甙与甲醇以1：1-1：3的重量比混合48-72小时后，过滤; （b）减压浓缩甲醇滤液，加入重量比为1:1的丁醇和水的混合溶液; （c）在减压下浓缩丁醇层的溶剂，并加入由甲醇和水组成的重量比为15:85的混合溶液和正己烷; 和（d）减压浓缩甲醇层的溶剂，并通过反向硅胶快速色谱法分离所需产物。
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公开(公告)号：KR1020070104715A
公开(公告)日：2007-10-29
申请号：KR1020060036547
申请日：2006-04-24
Applicant: 재단법인서울대학교산학협력재단
Inventor： 윤의준
IPC: H01L33/16
Abstract: A substrate with a pattern and a manufacturing method thereof are provided to improve the uniformity of the pattern by forming the pattern through deposition of the same amorphous as the substrate. An amorphous film is deposited on a single crystal substrate(20), the amorphous film being made of the same kind as the substrate. The amorphous film is patterned to form an amorphous film pattern. The amorphous film is recrystallized through heat treatment to form a single crystal pattern(22b). The substrate is made of sapphire, and the recrystallizing process is performed at a temperature of 900 to 1300 degrees under an atmosphere of oxygen, nitrogen or its mixture.
Abstract translation: 提供具有图案的基板及其制造方法，以通过通过沉积与基板相同的非晶形状来形成图案来提高图案的均匀性。 非晶膜沉积在单晶衬底（20）上，该非晶膜由与衬底相同的类型制成。 将非晶膜图案化以形成非晶膜图案。 通过热处理使非晶膜重结晶，形成单晶图案（22b）。 基板由蓝宝石制成，在氧，氮或其混合气氛下，在900〜1300度的温度下进行再结晶。
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