公开(公告)号：HK1171766A1

公开(公告)日：2013-04-05

申请号：HK12112366

申请日：2012-11-30

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS C C ,  HUNG ALFUR F F

IPC: C07K20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：AU2011296085A1

公开(公告)日：2013-03-28

申请号：AU2011296085

申请日：2011-08-30

Applicant: ACADEMIA SINICA ,  LIANG CHI MING

Inventor： WU HAN-CHUNG ,  LU RUEI-MIN

IPC: C12P21/06

Abstract: Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.

公开(公告)号：AU2009271411B2

公开(公告)日：2013-02-07

申请号：AU2009271411

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WANG CHENG-CHI ,  WU CHUNG-YI ,  WONG CHI-HUEY ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.

公开(公告)号：IL219898D0

公开(公告)日：2012-07-31

申请号：IL21989812

申请日：2012-05-20

Applicant: ACADEMIA SINICA

IPC: A61K20060101 ,  A61K38/16

公开(公告)号：CO6460701A2

公开(公告)日：2012-06-15

申请号：CO11144904

申请日：2011-10-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P21/02 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/11 ,  C07K14/135 ,  C07K14/18 ,  C12P21/02

Abstract: Se proveen composiciones inmunógenas que incluyen glucoproteínas víricas parcialmente glucosiladas para uso como vacunas contra virus. Las vacunas formuladas utilizando glucoproteínas de superficie víricas mono-, di-, o tri-glucosiladas y polipéptidos ofrecen protección amplia y potente contra virus, incluso a través de cepas. Se divulgan composiciones farmacéuticas que contienen polipéptidos de hemaglutinina monoglucosilada, y vacunas generadas a partir de ellos, y métodos de su uso para profilaxis o tratamiento de infecciones virales. Se divulgan métodos y composiciones para HA, NA y M2 del virus de la gripe, proteínas F, G y SH del VRS (virus respiratorio sincitial), glucoproteínas M o E del virus del dengue, glucoproteína E1 o E2 del virus de la hepatitis C y glucoproteínas gp120 y gp41 del VIH (virus de la inmunodeficiencia humana).

公开(公告)号：CL2011002354A1

公开(公告)日：2012-06-15

申请号：CL2011002354

申请日：2011-09-23

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/145 ,  C07K14/135 ,  C07K14/18

Abstract: Composición inmunogénica que permite aumentar una respuesta inmunitaria a un patógeno de origen viral, bacteriano, fúngico u otro que comprende una glicoproteína parcialmente glicosilada; vacuna que comprende polipéptido inmunogénico parcialmente glicosilado.

公开(公告)号：NZ590064A

公开(公告)日：2012-05-25

申请号：NZ59006409

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: A cancer diagnostic method that comprises the steps: (a) Providing a sample containing antibodies from a subject suspected of having cancer; (b) Incubating the sample with Gb5 and one or more of Globo H, Bb2, Bb3 and Bb4 to allow binding of the antibodies in the sample to the Gb5 and the Globo H, Bb2, Bb3 and Bb4; (c) Measuring the amount of the GB-5-bound antibodies and the amount of the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; (d) Determining whether the subject has the cancer based on the amounts of Gb5-bound antibodies and the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; The cancer is Globo H-positive and GB5-positive; and a higher ratio of the amount of Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies to the amount of Gb5-bound antibodies compared to a cancer-free subject indicates the subject has cancer. The cancer can be breast cancer, skin cancer, liver cancer, prostate cancer, ovary cancer, colon cancer, stomach cancer or pancreas cancer.

公开(公告)号：CA2854619A1

公开(公告)日：2012-05-10

申请号：CA2854619

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12N7/00 ,  C07K14/11 ,  C12N7/02 ,  C12N15/09 ,  C12P21/02

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：CA2835489A1

公开(公告)日：2011-11-17

申请号：CA2835489

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/7024 ,  A61P31/16 ,  G01N33/573

Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non- oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

公开(公告)号：AU2010229675A1

公开(公告)日：2011-10-27

申请号：AU2010229675

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  CHE MA ,  CHENG-CHI WANG ,  JUINE-RUEY CHEN

IPC: C07K14/11 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18 ,  C12P21/02

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.