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公开(公告)号：AT178049T
公开(公告)日：1999-04-15
申请号：AT94902209
申请日：1993-11-05
Applicant: ABBOTT LAB
Inventor： BASHA ANWER , BHATIA PRAMILA , BROOKS DEE W , CRAIG RICHARD A , RATAJCZYK JAMES D , STEWART ANDREW O
IPC: A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07C275/20
Abstract: PCT No. PCT/US93/10675 Sec. 371 Date Apr. 13, 1995 Sec. 102(e) Date Apr. 13, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/11342 PCT Pub. Date May 26, 1994The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
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公开(公告)号：ZA987555B
公开(公告)日：1999-02-23
申请号：ZA987555
申请日：1998-08-20
Applicant: ABBOTT LAB
Inventor： BLACK LAWRENCE A , BASHA ANWER , KOLASA TEODOZYJ , KORT MICHAEL E , LIU HUAQING , MCCARTY CATHERINE M , PATEL MEENA V , ROHDE JEFFREY J
IPC: C07D237/14 , C07D237/18 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D409/12 , C07D417/06 , C07D , A61K , C07F
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公开(公告)号：ES2095325T3
公开(公告)日：1997-02-16
申请号：ES91915194
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER , MARTIN JONATHAN G
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07C271/40 , C07D213/42 , C07D215/14 , C07D263/58
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公开(公告)号：DE69122759D1
公开(公告)日：1996-11-21
申请号：DE69122759
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE , STEWART ANDREW , KERKMAN DANIEL , BHATIA PRAMILA , BASHA ANWER , MARTIN JONATHAN
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
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公开(公告)号：ZA948309B
公开(公告)日：1995-08-04
申请号：ZA948309
申请日：1994-10-21
Applicant: ABBOTT LAB
Inventor： DELLARIA JOSEPH F , BASHA ANWER , BLACK LAWRENCE A , CHERNESKY LINDA J , LEE WENDY
IPC: C07C275/32 , C07C317/42 , C07C323/41 , C07C323/44 , C07C335/20 , C07D295/215 , A01N , A61K
Abstract: Compounds of structure where W is selected from the group consisting of where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR11, where R11 is hydrogen or alkyl, or where n=0, 1, or 2; and R5 and R6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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Patent Agency Ranking
公开(公告)号：ZA9408309B
公开(公告)日：1995-08-04
申请号：ZA9408309
申请日：1994-10-21
Applicant: ABBOTT LAB
Inventor： DELLARIA JOSEPH F , BASHA ANWER , BLACK LAWRENCE A , CHERNESKY LINDA J , LEE WENDY
IPC: C07C275/32 , C07C317/42 , C07C323/41 , C07C323/44 , C07C335/20 , C07D295/215 , A01N , A61K
CPC classification number: C07D295/215 , C07C275/32 , C07C317/42 , C07C323/41 , C07C323/44 , C07C335/20 , C07C2601/14
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公开(公告)号：ZA9408250B
公开(公告)日：1995-08-02
申请号：ZA9408250
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： DELLARIA JOSEPH F , BLACK LAWRENCE A , LEE WENDY , BASHA ANWER , CHERNESKY LINDA J
IPC: C07D309/10 , C07D405/12 , A01N , A61K
CPC classification number: C07D405/12 , C07D309/10
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48.发明专利
公开(公告)号：CA2136077A1
公开(公告)日：1994-05-26
申请号：CA2136077
申请日：1993-11-05
Applicant: ABBOTT LAB
Inventor： BASHA ANWER , BHATIA PRAMILA , BROOKS DEE W , CRAIG RICHARD A , RATAJCZYK JAMES D , STEWART ANDREW O
IPC: A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D333/24 , C07D413/06 , C07D417/06 , C07D277/30 , C07D263/32 , A61K31/33 , C07D307/54 , C07D333/60
Abstract: 2136077 9411342 PCTABS00032 The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
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公开(公告)号：AU8414291A
公开(公告)日：1992-02-18
申请号：AU8414291
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D333/36 , C07D307/66
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公开(公告)号：PL398491A1
公开(公告)日：2012-06-04
申请号：PL39849101
申请日：2001-04-27
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , TIETJE KARIN R , TOUPENCE RICHARD B , JI JIANGUO , BASHA ANWER , BUNNELLE WILLIAM H , DAANEN JEROME F , PACE JENNIFER M , SIPPY KEVIN B
IPC: C07D231/54 , C07D487/08 , A61K31/454 , A61K31/4545 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/34 , C07D471/04 , C07D471/08 , C07D487/04
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