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公开(公告)号：PL333920A1
公开(公告)日：2000-01-31
申请号：PL33392097
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：CZ204899A3
公开(公告)日：2000-01-12
申请号：CZ204899
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHAN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B
IPC: A61K31/44 , A61P25/04 , C07D205/04 , C07D401/12
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公开(公告)号：TR9901904T2
公开(公告)日：1999-10-21
申请号：TR9901904
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
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公开(公告)号：NO992705D0
公开(公告)日：1999-06-03
申请号：NO992705
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：CA2273917A1
公开(公告)日：1998-06-18
申请号：CA2273917
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , HOLLADAY MARK W , LIN NAN-HORNG , BAI HAO , SULLIVAN JAMES P , WASICAK JAMES T , RYTHER KEITH B , ARNERIC STEPHEN P , DART MICHAEL J , LYNCH JOHN K , OR YAT SUN
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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Patent Agency Ranking
公开(公告)号：BRPI0712720A2
公开(公告)日：2012-11-20
申请号：BRPI0712720
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMAIRE , KOLASA TEODOZYJ
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：ECSP089020A
公开(公告)日：2009-01-30
申请号：ECSP089020
申请日：2008-12-29
Applicant: ABBOTT LAB
Inventor： TIETJE KARIN R , KOLASA TEODOZYJ , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEL , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B
IPC: A61K31/426 , A61P29/00
Abstract: Compuestos de la fórmula (I), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde R1, R2, R3, R4, y L1 se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invención también se refiere a compuestosde fórmula (II), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, (II) donde R1a, R2a y (Rx)n tienen los valores definidos en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：MX2008015214A
公开(公告)日：2008-12-12
申请号：MX2008015214
申请日：2007-05-31
Applicant: ABBOTT LAB
Inventor： PEREZ-MEDRANO ARTURO , DART MICHAEL J , GALLAGHER MEGAN E , RYTHER KEITH B , CARROLL WILLIAM A , FLORJANCIC ALAN S , NELSON DEREK W , KOLASA TEODOZYJ , PATEL MEENA V , LI TONGMEI , FROST JENNIFER M , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
Abstract: La presente invención se refiere a compuestos de la fórmula (I), o sales farmacéuticamente aceptables, profármacos, sales de profármacos, o combinaciones de los mismos, en donde R1, R2, R3, R4 y L2 se definen en la descripción, composiciones que comprenden dichos compuestos, y métodos para el tratamiento de condiciones y trastornos utilizando dichos compuesto y composiciones. (ver fórmula (I)).
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公开(公告)号：DE60038823D1
公开(公告)日：2008-06-19
申请号：DE60038823
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , BARLOCCO CRISTINA DANIELA , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: C07D487/08 , A61K31/00 , A61K31/395 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：CA2647598A1
公开(公告)日：2007-12-06
申请号：CA2647598
申请日：2007-05-31
Applicant: ABBOTT LAB
Inventor： TIETJE KARIN ROSEMARIE , RYTHER KEITH B , LI TONGMEI , KOLASA TEODOZYJ , GALLAGHER MEGAN E , FROST JENNIFER M , FLORJANCIC ALAN S , CARROLL WILLIAM A , DART MICHAEL J , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , NELSON DEREK W
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
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