公开(公告)号：AU711852B2

公开(公告)日：1999-10-21

申请号：AU1541697

申请日：1997-01-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：AU706859B2

公开(公告)日：1999-06-24

申请号：AU7491296

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CZ9900829A3

公开(公告)日：1999-06-16

申请号：CZ82999

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

公开(公告)号：CA2298659A1

公开(公告)日：1999-02-11

申请号：CA2298659

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JURGEN ,  ROSENBERG JORG ,  BREITENBACH JORG ,  BERNDL GUNTHER ,  VOLLGRAF CHRISTIANE ,  NEUMANN JORG ,  LIEPOLD BERND

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: The invention relates to a fast-acting analgesic, containing ibuprofen as the active analgesic substance in an auxiliary substance matrix, with a porous structure and a density of greater than 1 - 2.5 g/cm3.

公开(公告)号：ES2118588T3

公开(公告)日：1998-09-16

申请号：ES95915195

申请日：1995-04-08

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  SANNER AXEL ,  THOMA DIETRICH

IPC: A01N59/12

Abstract: PCT No. PCT/EP95/01299 Sec. 371 Date Oct. 17, 1996 Sec. 102(e) Date Oct. 17, 1996 PCT Filed Apr. 8, 1995 PCT Pub. No. WO95/28841 PCT Pub. Date Nov. 2, 1995Iodophore containing a) 20-71% by weight of PVP or poly-N-vinylcaprolactam, b) 20-71% by weight of dextrin of DE 2-40, c) 6-25% by weight of elemental iodine, d) 3-12.5% by weight of iodide ions, and process for its preparation are disclosed.

公开(公告)号：MX9605678A

公开(公告)日：1998-04-30

申请号：MX9605678

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: Un procedimiento para producir composiciones de sustancia activa en forma de una solucion solida de la sustancia activa en una matriz de polímero, que comprende la extrusion en fusion de la sustancia activa en una forma no ionica junto con un polímero y una sal.

公开(公告)号：MX9605010A

公开(公告)日：1998-02-28

申请号：MX9605010

申请日：1995-04-08

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  SANNER AXEL ,  THOMA DIETRICH

Abstract: Un yodoforo, el cual contiene: a) del 20 al 71% en peso de la PVP o poli-N-vinil-caprolactama; b) del 20 al 71% en peso de dextrina con un equivalente de dextrosa de 2 a 40; c) del 6 al 25% en peso de yodo elemental, d) del 3 al 12 % en peso de iones de yoduro. Y un procedimiento para su preparacion.

公开(公告)号：BR9605886A

公开(公告)日：1997-09-16

申请号：BR9605886

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：AU7283396A

公开(公告)日：1997-04-28

申请号：AU7283396

申请日：1996-09-30

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/20

公开(公告)号：AU5106996A

公开(公告)日：1996-10-08

申请号：AU5106996

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.