公开(公告)号：GR77632B

公开(公告)日：1984-09-25

申请号：GR810166899

申请日：1981-12-23

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER DR ,  JOSEFGRIES DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS JURGEN DR ,  HOFMANN HANS PETER DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DE3260540D1

公开(公告)日：1984-09-13

申请号：DE3260540

申请日：1982-06-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR ,  KOENIG HORST DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：DE2966809D1

公开(公告)日：1984-04-19

申请号：DE2966809

申请日：1979-12-06

Applicant: BASF AG

Inventor： THYES MARCO DR DIPL CHEM ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：DE2961499D1

公开(公告)日：1982-01-28

申请号：DE2961499

申请日：1979-03-31

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  FRICKEL FRITZ-FRIEDER DR ,  HAGEN HELMUT DR ,  FRANKE ALBRECHT DR ,  LENKE DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

Abstract: Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds, which may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：DE2861089D1

公开(公告)日：1981-12-03

申请号：DE2861089

申请日：1978-06-01

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  THYES MARCO DR ,  KOENIG HORST DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：CS8400509A2

公开(公告)日：1987-07-16

申请号：CS50984

申请日：1984-01-23

Applicant: BASF AG

Inventor： ROSSY PHILIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  LEHMANN HANS D DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

公开(公告)号：DE3269241D1

公开(公告)日：1986-03-27

申请号：DE3269241

申请日：1982-11-19

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER DR

IPC: A61K31/505 ,  A61P37/08 ,  C07D239/95 ,  C07D487/04 ,  C07D491/04 ,  C07D491/14 ,  C07D491/147

Abstract: 1,2,4-Triazolo[1,5-c]-quinazolinones of the general formula I (I) and their pharmaceutically tolerated salts, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful drugs in the treatment of allergic disorders.

公开(公告)号：DE3268963D1

公开(公告)日：1986-03-20

申请号：DE3268963

申请日：1982-09-09

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER JOSEF DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DR ,  HEGE HANS-GUENTHER DR ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  VON PHILIPSBORN GERDA DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C93/06 ,  C07C149/24 ,  C07C93/14

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：AT17248T

公开(公告)日：1986-01-15

申请号：AT83103311

申请日：1983-04-05

Applicant: BASF AG

Inventor： OSTERSEHLT BERND DR ,  FRANKE ALBRECHT DR ,  FRICKEL FRITZ-FRIEDER DR ,  THYES MARCO DR ,  FRIEDRICH LUDWIG DR ,  GRIES JOSEF DR ,  LENKE DIETER DR

IPC: C07D405/12 ,  A61K31/415 ,  A61P1/04 ,  A61P43/00 ,  C07D233/61 ,  C07D521/00

公开(公告)号：AT16384T

公开(公告)日：1985-11-15

申请号：AT81110718

申请日：1981-12-23

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  STEINER GERD DR ,  THIEME PETER C DR ,  LENKE DIETER DR ,  GRIES JOSEF DR ,  TESCHENDORF HANS-JUERGEN DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P9/02 ,  A61P11/08 ,  A61P25/08 ,  A61P25/20 ,  C07D231/12 ,  C07D231/38 ,  C07D233/60 ,  C07D233/88 ,  C07D239/42 ,  C07D261/08 ,  C07D295/06 ,  C07D295/092 ,  C07D521/00