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公开(公告)号：CA2738626C
公开(公告)日：2017-08-08
申请号：CA2738626
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
Abstract: Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
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公开(公告)号：AU2009300369B2
公开(公告)日：2014-08-14
申请号：AU2009300369
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
Abstract: Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
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43.发明专利
公开(公告)号：AU2007215242B2
公开(公告)日：2012-10-18
申请号：AU2007215242
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZACCARIN DENIS , FOQUET MATHIEU , MAXHAM MARK , TURNER STEPHEN , LUNDQUIST PAUL , LACROIX YVES
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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公开(公告)号：CA2737505A1
公开(公告)日：2010-03-25
申请号：CA2737505
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：AU2008251861A1
公开(公告)日：2008-11-20
申请号：AU2008251861
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , ZHONG CHENG-FRANK , LUNDQUIST PAUL , ZACCARIN DENIS
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Patent Agency Ranking
公开(公告)号：CA2616439A1
公开(公告)日：2007-02-15
申请号：CA2616439
申请日：2006-08-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
Abstract: Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical sign al is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.
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47.发明公开METHODS AND SYSTEMS FOR ANALYSIS OF FLUORESCENT REACTIONS WITH MODULATED EXCITATION 审中-公开方法和系统的分析荧光反应的方法调制的激发
公开(公告)号：EP2245444A4
公开(公告)日：2014-04-16
申请号：EP09700236
申请日：2009-01-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUONG KHAI , LUNDQUIST PAUL , DALAL RAVI , LYLE JOHN , TURNER STEPHEN
CPC classification number: C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
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48.发明公开METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES 有权用于同时实时监测来自多个源的光信号的方法和系统
公开(公告)号：EP1984712A4
公开(公告)日：2013-02-20
申请号：EP07750629
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZACCARIN DENIS , LACROIX YVES , TURNER STEPHEN , DIXON JOHN
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2021/6441
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公开(公告)号：EP2331934A4
公开(公告)日：2015-04-01
申请号：EP09814888
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/6825 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6463 , G01N2201/06113 , G01N2201/0638 , G01N2201/08
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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50.发明公开METHODS AND SYSTEMS FOR MONITORING MULTIPLE OPTICAL SIGNALS FROM A SINGLE SOURCE 审中-公开方法和系统几种光信号从一个源监测
公开(公告)号：EP1920277A4
公开(公告)日：2013-01-16
申请号：EP06813384
申请日：2006-08-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
CPC classification number: G01N21/6452 , G01J3/2803 , G01J3/36 , G01N21/6428
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