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    COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
    44.
    发明专利
    COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING 未知

    公开(公告)号：CA2719747C

    公开(公告)日：2018-02-20

    申请号：CA2719747

    申请日：2009-03-27

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： TRAVERS KEVIN ,  OTTO GEOFF ,  TURNER STEPHEN ,  HEINER CHERYL ,  MA CONGCONG

    IPC: C12Q1/68 ,  C12Q1/6869

    Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.

    Compositions and methods for nucleic acid sequencing
    45.
    发明专利
    Compositions and methods for nucleic acid sequencing 未知

    公开(公告)号：AU2015202111B9

    公开(公告)日：2017-07-27

    申请号：AU2015202111

    申请日：2015-04-24

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： TRAVERS KEVIN ,  OTTO GEOFF ,  TURNER STEPHEN ,  HEINER CHERYL ,  MA CONGCONG

    IPC: C12Q1/68

    Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.

    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE
    46.
    发明专利
    METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 未知

    公开(公告)号：CA2687062C

    公开(公告)日：2016-04-12

    申请号：CA2687062

    申请日：2008-05-09

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： LUNDQUIST PAUL ,  ZHONG CHENG-FRANK ,  ZACCARIN DENIS ,  ZHAO PEIQIAN ,  TURNER STEPHEN

    IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/68 ,  C40B60/00 ,  G01N33/52

    Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    Integrated analytical system and method
    49.
    发明专利
    Integrated analytical system and method 未知

    公开(公告)号：AU2014202286B2

    公开(公告)日：2015-01-29

    申请号：AU2014202286

    申请日：2014-04-28

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： MCCAFFREY NATHANIEL JOSEPH ,  TURNER STEPHEN ,  SAXENA RAVI ,  HELGESEN SCOTT EDWARD

    IPC: G01N21/00

    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

    Integrated analytical system and method
    50.
    发明专利
    Integrated analytical system and method 未知

    公开(公告)号：AU2011217862B9

    公开(公告)日：2014-07-10

    申请号：AU2011217862

    申请日：2011-02-18

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： MCCAFFREY NATHANIEL JOSEPH ,  TURNER STEPHEN ,  SAXENA RAVI ,  HELGESEN SCOTT EDWARD

    Abstract: A sequencing chip and a corresponding method for distinguishing fluorescently labelled species at a single molecule level, the chip comprising:a plurality of analytical devices, each analytical device having a reaction cell, an optical element and a detection element, wherein a sample is disposed at the reaction cell, and the optical element is in optical communication with the reaction cell and the detection element;a plurality of sources emitting at different wavelengths at different times; andone or more integrated waveguides in optical communication with the reaction cells to deliver a pulsed illumination to the reaction cells, wherein the pulsed illumination comprises two or more pulses at different wavelengths and different times, and the different wavelengths correspond to different excitation spectra of a plurality of fluorophores;wherein for each analytical device in the plurality of analytical devices:the pulsed illumination produces excitation events from the sample at the reaction cell, each excitation event producing an emitted signal;the optical element delivers the emitted signals to the detection element; andthe detection element detects the emitted signals by correlating the timing of the emitted signals detected at the detection element with the timing of the excitation events, thereby identifying whether any fluorophore in the plurality of fluorophores is present or absent in the reaction cell..

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