公开(公告)号：CA2709301C

公开(公告)日：2016-05-10

申请号：CA2709301

申请日：2008-12-12

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  GROOTENHUIS PETER D J ,  PIERCE ALBERT ,  FANNING LEV T D

IPC: C07D487/04 ,  A61K31/517 ,  A61K31/519 ,  A61P1/18 ,  A61P3/06 ,  A61P25/16 ,  A61P25/28

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof of formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.

公开(公告)号：DK2674428T3

公开(公告)日：2016-04-18

申请号：DK13167785

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  YANG XIAOQING

IPC: C07D405/12 ,  A61K31/404 ,  A61P31/00 ,  C07D405/14 ,  C07D471/04

公开(公告)号：BR112012008082A2

公开(公告)日：2016-03-01

申请号：BR112012008082

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： GROSSI ALFREDO ,  YOUNG CHRISTOPHER R ,  GOOR FREDRICK F VAN ,  ZLOKARNIK GREGOR ,  DINEHART KIRK ,  OVERHOFF KIRK ,  VERWIJS MARINUS JACOBUS ,  BOTFIELD MARTYN ,  HURTER PATRICIA ,  GROOTENHUIS PETER D J ,  ROWE WILLIAM

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

公开(公告)号：HK1205741A1

公开(公告)日：2015-12-24

申请号：HK15106317

申请日：2012-07-06

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  ROPER STEFANIE ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  GROOR FREDERICK F VAN ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D20060101

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 2; in the presence of a coupling agent.

公开(公告)号：CA2627358C

公开(公告)日：2015-10-06

申请号：CA2627358

申请日：2006-11-08

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  HAMILTON MATTHEW ,  MILLER MARK ,  GROOTENHUIS PETER D J ,  BEAR BRIAN ,  MCCARTNEY JASON ,  ZHOU JINGLAN

IPC: C07D405/12 ,  A61K31/4418 ,  A61K31/5585 ,  A61P11/00 ,  C07D213/75 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). In one broad aspect, there is disclosed a compound of the general formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R'3, R4, and n are described herein. In a more specific embodiment, the invention relates to a compound having the following formula: (see formula II).

公开(公告)号：DK2007756T3

公开(公告)日：2015-10-05

申请号：DK07755298

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  VAN GOOR FREDRICK ,  YANG XIAOQING

IPC: C07D405/12 ,  A61K31/404 ,  A61P31/00 ,  C07D405/14

公开(公告)号：AU2015203461A1

公开(公告)日：2015-08-06

申请号：AU2015203461

申请日：2015-06-23

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  MILLER MARK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  GROOTENHUIS PETER D J

IPC: C07D217/22 ,  A61K31/472 ,  A61K31/4725 ,  A61P11/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14

Abstract: Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. I R3' y, -N O (R1 )n (I)

公开(公告)号：PL2365972T3

公开(公告)日：2015-05-29

申请号：PL08876364

申请日：2008-11-12

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  MILLER MARK T ,  MCCARTNEY JASON ,  ZHOU JINGLAN ,  BEAR BRIAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D405/12 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00

公开(公告)号：SI2365972T1

公开(公告)日：2015-04-30

申请号：SI200831394

申请日：2008-11-12

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  MILLER MARK T ,  MCCARTNEY JASON ,  ZHOU JINGLAN ,  BEAR BRIAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D405/00 ,  A61K31/00 ,  A61P3/00 ,  A61P25/00

公开(公告)号：SI1773816T1

公开(公告)日：2015-04-30

申请号：SI200531953

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D215/00 ,  A61K31/00 ,  A61P1/00 ,  A61P3/00 ,  A61P5/00 ,  A61P11/00 ,  A61P25/00 ,  A61P31/00